Chem Asian J. 2026 Apr;21(7):e70715. doi: 10.1002/asia.70715. ABSTRACT Smiles and Truce-Smiles rearrangements have evolved from classical nucleophilic aromatic substitutions into a versatile platform for radical aryl migration and molecular editing. This Review surveys how visible-light photoredox catalysis and related photoinduced activation modes-including electron-donor-acceptor (EDA) complexes, energy-transfer and ligand-to-metal charge-transfer (LMCT) processes, metal-hydride hydrogen atom transfer…

Microbiologyopen. 2026 Apr;15(2):e70283. doi: 10.1002/mbo3.70283. ABSTRACT Bacterial biofilms on medical implants are a major problem, typically requiring explantation and replacement of the biofilm-colonized implant. Thermal mitigation of these biofilms in situ has shown great promise in the laboratory, where the thermal shock can be most precisely delivered by immersion in hot media. Clinical implementation requires…

Protein Sci. 2026 May;35(5):e70555. doi: 10.1002/pro.70555. ABSTRACT Flexible loops within enzyme active sites are central to substrate binding, transition-state stabilization, and catalytic turnover. Hydrophobic interactions modulate ligand recognition and influence protein function. Here, we interrogated loop-mediated hydrophobic contributions to catalysis in 3α-hydroxysteroid dehydrogenase/carbonyl reductase (3α-HSD/CR) from Comamonas testosteroni. Residue L193 on the flexible substrate-binding loop…

Appl Environ Microbiol. 2026 Apr 6:e0190825. doi: 10.1128/aem.01908-25. Online ahead of print. ABSTRACT Current research on interfacial enzyme catalysis of starch granules largely overlooks interactions with molecules of specific spatial conformations. Here, we demonstrated that the CBM20-truncated mutant AmyM-TR2 exhibited over 30-fold greater hydrolysis efficiency toward starch granules compared to wild-type AmyM, with a shifted…

Eur J Med Chem. 2026 Apr 2;311:118825. doi: 10.1016/j.ejmech.2026.118825. Online ahead of print. ABSTRACT The natural steroidal compound diosgenin possesses neuroprotective pharmacological activity. To obtain compounds with enhanced activity, this study, based on the molecular hybridization strategy, firstly synthesized a series of C-3 position substituted derivatives (DG1-DG15) via esterification reactions between diosgenin and cinnamic acid…

J Agric Food Chem. 2026 Apr 4. doi: 10.1021/acs.jafc.6c01503. Online ahead of print. ABSTRACT Designing biocatalytic cascades with precise control over coenzyme regeneration, efficiency, and selectivity remains a central challenge in biocatalysis. Here, we present a sustainable strategy for constructing covalently bonded multienzyme complexes (CBMEs) that enable efficient redox biosynthesis under mild and environmentally friendly…

Chembiochem. 2026 Apr 14;27(7):e70287. doi: 10.1002/cbic.70287. ABSTRACT Laccases are biocatalysts with a high potential for developing green procedures to achieve new compounds. This study employed laccases in buffer solution to synthesize dimeric neolignans from honokiol and magnolol. Four laccases (LTV, POXA1b, EV3, and EV4) were first screened for honokiol dimerization in the presence of the…

Int J Biol Macromol. 2026 Apr 2:151813. doi: 10.1016/j.ijbiomac.2026.151813. Online ahead of print. ABSTRACT Interleukin-13 (IL-13) drives inflammatory responses in type 2 inflammatory disorders by binding to the IL-4Rα/IL-13Rα1 receptor complex. Anti-IL-13 monoclonal antibodies such as tralokinumab and lebrikizumab showed substantial clinical efficacy in autoimmunology diseases such as atopic dermatitis and asthma. However, their large…

Biotechnol J. 2026 Apr;21(4):e70222. doi: 10.1002/biot.70222. ABSTRACT The GRASE deep-learning framework overcomes the enzyme activity-stability trade-off to discover AbPURase, a robust biocatalyst that efficiently depolymerizes polyurethane waste in harsh industrial conditions, enabling scalable, closed-loop chemical recycling. PMID:41934218 | DOI:10.1002/biot.70222