BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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MAbs. 2026 Dec;18(1):2652642. doi: 10.1080/19420862.2026.2652642. Epub 2026 Apr 2. ABSTRACT Monoclonal antibodies (mAbs) can mediate their therapeutic activity through antigen binding and by engaging Fc receptors (FcRs) or the complement system. FcRs are expressed on immune cells and can initiate effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis. The conserved Fc…
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J Am Chem Soc. 2026 Apr 2. doi: 10.1021/jacs.5c20207. Online ahead of print. ABSTRACT Two-dimensional (2D) nanomaterials have attracted considerable attention across diverse research fields owing to their unique physicochemical properties; however, achieving the controllable fabrication of freestanding 2D nanosheets through a template-free method under physiological conditions remains challenging. Here, an enzyme catalysis induced nanocluster…
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J Am Chem Soc. 2026 Apr 2. doi: 10.1021/jacs.6c03427. Online ahead of print. ABSTRACT Pyrroloquinoline quinone (PQQ) is a bacterial redox cofactor enabling enzyme catalysis in various sugar and alcohol dehydrogenases. However, its proposed additional role as a “longevity vitamin” lacks a clear molecular basis and is thus highly debated. Here, we applied chemical proteomics…
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Org Lett. 2026 Apr 2. doi: 10.1021/acs.orglett.6c00842. Online ahead of print. ABSTRACT Enantioenriched α-halo- and α,α-dihalo β-hydroxy esters serve as versatile building blocks for various bioactive molecules and pharmaceutical ingredients. We developed an electroenzymatic sequential platform for the synthesis of enantioenriched α-chloro- and α,α-dichloro β-hydroxy esters using the readily available β-keto esters. The protocol integrates…
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J Phys Chem B. 2026 Apr 2. doi: 10.1021/acs.jpcb.6c00550. Online ahead of print. ABSTRACT Electrostatic interactions play a central role in enzyme catalysis by stabilizing charge redistribution along the reaction coordinate. In liver alcohol dehydrogenase (LADH), experimental measurements using vibrational probes interpreted through Vibrational Stark Effect (VSE) spectroscopy have demonstrated a strong correlation between the…
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J Agric Food Chem. 2026 Apr 1. doi: 10.1021/acs.jafc.5c14597. Online ahead of print. ABSTRACT Pyrethroid insecticides are extensively applied owing to their potent insecticidal activity and low mammalian toxicity, yet their hydrophobicity results in persistent environmental residues. Here, we engineered a Bacillus subtilis spore surface display system to anchor Pseudomonas aeruginosa aminopeptidase (PaAps) on the…
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Plant J. 2026 Apr;126(1):e70816. doi: 10.1111/tpj.70816. ABSTRACT Early-diverging Mucoromycotina fungi are widely recognized for promoting plant growth and development. However, the specific volatile organic compounds (VOCs) involved and their underlying mechanisms remain largely unknown. In this study, we used a non-contact co-culture system to investigate the effects of VOCs emitted during the interaction between the…
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J Phys Chem B. 2026 Apr 1. doi: 10.1021/acs.jpcb.6c00014. Online ahead of print. ABSTRACT The reaction mechanism of Bacillus safensis nitrilase (BsNIT) toward the aliphatic dinitrile substrate pentanedinitrile (PD) was elucidated using quantum mechanical dynamics (QMD) simulations containing a cluster model having the catalytic triad (C164, K130, and E38). The elucidated reaction mechanism pathway revealed…
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ACS Synth Biol. 2026 Apr 1. doi: 10.1021/acssynbio.5c00735. Online ahead of print. ABSTRACT Ergothioneine (EGT) is a unique natural chiral compound endowed with potent antioxidative, anti-inflammatory, and cytoprotective properties. Currently, EGT is primarily produced via bioextraction from mushrooms and chemical synthesis; however, the low efficiency and high costs associated with these methods hinder their ability…
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Appl Biochem Biotechnol. 2026 Apr 1. doi: 10.1007/s12010-026-05681-2. Online ahead of print. NO ABSTRACT PMID:41920280 | DOI:10.1007/s12010-026-05681-2