Trends Biotechnol. 2026 Sep 19:S0167-7799(26)00377-X. doi: 10.1016/j.tibtech.2026.09.007. Online ahead of print. ABSTRACT When replacing expensive redox cofactors, making biomimetic cofactors with desirable thermostability and redox properties is only half of the equation; enzymes must also be able to use them. Ji and colleagues confront that trade-off by pairing the development of a thermostable carbocyclic cofactor…

J Organomet Chem. 2026 Apr 1;1049:124074. doi: 10.1016/j.jorganchem.2026.124074. Epub 2026 Feb 12. ABSTRACT [2Fe2S] synthetic model complexes serve as benchmarks for intermediates proposed in enzyme catalysis, and elucidate how structural effects influence the electronic structure of the cluster. Access to [2Fe2S]1+ complexes has been synthetically challenging, with most clusters degrading or aggregating upon reduction. Here,…

Food Chem. 2026 Sep 13;529:151106. doi: 10.1016/j.foodchem.2026.151106. Online ahead of print. ABSTRACT Accurate on-site detection of food spoilage indicators constitutes a fundamental requirement for evaluating food freshness and ensuring safety. In this work, a dual-mode sensor (CDs/AuNCs) integrating carbon dots and gold nanoclusters was reported, which enabled the rapid detection of putrescine within 20 s.…

ACS Omega. 2026 Sep 1;11(36):54593-54602. doi: 10.1021/acsomega.6c07054. eCollection 2026 Sep 15. ABSTRACT In this work, the design of CYP116B5-SOX-(PPII) is presented. This is an artificial self-sufficient enzyme in which the P450 116B5 peroxygenase and the H2O2-generating sarcosine oxidase (SOX) are linked together in a fusion complex. A polyproline type II helix (PPII) linker was used…

ACS Sens. 2026 Sep 18. doi: 10.1021/acssensors.6c02078. Online ahead of print. ABSTRACT Traditional nanozymes suffer from inefficient catalytic kinetics and slow signal response, limiting their use in rapid-response sensors for real-sample analysis. Herein, we developed an external electrical stimulation regulation strategy that directly drives valence cycling in bimetallic MOF nanozymes. This approach reduces the activation…

J Biol Chem. 2026 Sep 17:113573. doi: 10.1016/j.jbc.2026.113573. Online ahead of print. ABSTRACT The RNA demethylase FTO acts as a methyl ‘eraser’ to remove either internal N6-methyladenosine (m6A) or 5′ end N6-2′-O-dimethyladenosine (m6Am) modifications on mRNA. FTO has an intrinsic preference and significantly faster demethylation rates in vitro for m6Am modifications located at the 5′…

J Environ Manage. 2026 Sep 17;417:130902. doi: 10.1016/j.jenvman.2026.130902. Online ahead of print. ABSTRACT For economic and effective enzymatic conversion of abundant starch-containing food waste into cyclodextrin, the development of efficient and stable immobilization support is essential. In this study, UiO-66, a water-stable zirconium-based metal-organic framework (MOFs), was surface-modified using sodium palmitate and employed as a…

Nature. 2026 Sep;657(8132):611-620. doi: 10.1038/s41586-026-10918-5. Epub 2026 Sep 16. ABSTRACT The discovery and engineering of enzymes capable of depolymerizing synthetic polymers with hydrolysable backbone linkages is now enabling biotechnological solutions for plastics recycling. Polyolefins and other non-hydrolysable polymers, however, have saturated carbon-carbon linkages that are more challenging to cleave biologically. Despite decades of research, the…