BioCat Collective

Educating and Building a Broader Biocatalysis Community

Deep Learning as a Compass for Industrial Biocatalysis: The Grase Framework Rewrites the Rules for Polyurethane Recycling

Biotechnol J. 2026 Apr;21(4):e70222. doi: 10.1002/biot.70222.

ABSTRACT

The GRASE deep-learning framework overcomes the enzyme activity-stability trade-off to discover AbPURase, a robust biocatalyst that efficiently depolymerizes polyurethane waste in harsh industrial conditions, enabling scalable, closed-loop chemical recycling.

PMID:41934218 | DOI:10.1002/biot.70222

biocatcollective_cbppkd