BioCat Collective

Nat Commun. 2026 May 5;17(1):4071. doi: 10.1038/s41467-026-72558-7. ABSTRACT The fixation of dissolved inorganic carbon (DIC) such as CO2 and bicarbonate is fundamental to the global primary production. Many autotrophs depend on a diversity of CO2-concentrating mechanisms (CCMs) to overcome the inefficiency of ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and the limited supply of… Read more: Structural basis of membrane potential coupled vectorial CO₂ hydration by the DAB2 complex in chemolithoautotrophs

Nat Prod Rep. 2026 May 5. doi: 10.1039/d6np00006a. Online ahead of print. ABSTRACT Covering: up to January 2026Methyltransferases (EC 2.1.1.-) represent one of the most functionally diverse enzyme families in biology. Found across all domains of life-including bacteria, archaea, eukaryotes, and viruses-these enzymes catalyze a wide range of methylation reactions,… Read more: High-throughput assays for SAM-dependent methyltransferases: advances, challenges, and future perspectives

Food Res Int. 2026 Jul 1;235:119177. doi: 10.1016/j.foodres.2026.119177. Epub 2026 Apr 15. ABSTRACT Metal-organic frameworks (MOFs) with tunable porosity are promising carriers for enzyme immobilization, but their practical application is limited by structural instability and difficult recovery. We previously developed an oxidation-reduction (O-R) pyrolysis strategy for mesoporous MIL-88 A, yielding… Read more: Magnetic MOF derivatives from Tunable MIL-88A for enhanced lipase immobilization and phosphatidyl EPA/DHA synthesis

Microb Biotechnol. 2026 May;19(5):e70369. doi: 10.1111/1751-7915.70369. ABSTRACT Cytochrome P450 monooxygenases (P450s) not only play many physiological roles in oxidative metabolism but are also promising biocatalysts for the synthesis of organic molecules. Bacillus subtilis strain 168, which possesses eight P450 genes, has been extensively studied as a model bacterium, but the… Read more: Characterization of the Orphan Cytochrome P450 CYP107J1 From Bacillus subtilis Through Peroxygenase Activity Engineering

Acta Naturae. 2026 Jan-Mar;18(1):83-90. doi: 10.32607/actanaturae.27820. ABSTRACT Pyridoxal-5′-phosphate (PLP)-dependent transaminases are highly efficient biocatalysts for the stereoselective synthesis of chiral amines, which are key building blocks in pharmaceuticals and chemical manufacturing. Fundamental research on enzymatic transamination includes the classical works of Alexander Braunstein, who discovered the transamination reaction; David Metzler,… Read more: Stabilization of Transaminases in Aqueous-Organic Media by Pyridoxal-5′-phosphate: A Case Study of Transaminase from Desulfomonile tiedjei

J Agric Food Chem. 2026 May 5. doi: 10.1021/acs.jafc.6c03303. Online ahead of print. ABSTRACT Fungal DMATS-type prenyltransferases catalyze the prenylation of diverse natural products, particularly indole derivatives, but also plant metabolites such as flavonoids. The prenyltransferase UcdE from Aspergillus ustus was previously suggested to catalyze ortho-prenylation of the p-terphenyl derivative… Read more: A Fungal <em>p</em>-Terphenyl Prenyltransferase for Regioselective <em>C</em>-Prenylation of Flavonoids and Other Compounds Bearing <em>ortho</em>-Dihydroxyphenyl Moieties

Protein Sci. 2026 Jun;35(6):e70598. doi: 10.1002/pro.70598. ABSTRACT The bio-based platform chemical 3-hydroxypropionic acid (3-HP) has attracted considerable attention as a precursor for the production of various value-added chemicals, motivating extensive efforts to biosynthesize it using engineered microbial cell factories. Among the known pathways, the cascade of glycerol dehydratase (GDHt) and… Read more: Engineering a self-organized enzyme cascade for enhanced cell-free biosynthesis of 3-hydroxypropionic acid

J Chem Inf Model. 2026 May 4. doi: 10.1021/acs.jcim.6c00576. Online ahead of print. ABSTRACT Stereodivergence is an important method in biocatalysis to access all possible stereoisomers by performing minimal changes in the enzymatic system. However, the growth remains slow due to an incomplete understanding of the role of mutations. Herein,… Read more: QM/MM Calculations Reveal the Molecular Origin of Stereodivergence in a CALB-Catalyzed Transacylation

Front Immunol. 2026 Apr 17;17:1812063. doi: 10.3389/fimmu.2026.1812063. eCollection 2026. ABSTRACT INTRODUCTION: CD28 is a critical co-stimulatory receptor expressed on T cells. Alongside the T-cell receptor (TCR), it provides a dual-signal requirement that is necessary for the complete activation of T cells. Developing co-stimulatory agonists targeting CD28 therefore represents a promising… Read more: Discovery of co-stimulatory anti-CD28 VHHs for developing cancer immune therapeutic anti-tumor/CD3/CD28 trispecific T cell engager

Bioengineering (Basel). 2026 Apr 16;13(4):465. doi: 10.3390/bioengineering13040465. ABSTRACT Biomineralization has recently emerged as a highly effective strategy for enzyme immobilization. Zeolitic imidazolate frameworks (ZIFs), a subclass of metal-organic frameworks (MOFs), are particularly attractive carriers due to their structural tunability and chemical stability. While ZIF-8 has been extensively studied, its denser… Read more: Biomineralization of Glucose Oxidase from <em>Aspergillus niger</em> in ZIF-zni for Enhanced Biocatalytic Performance

J Am Chem Soc. 2026 Apr 29. doi: 10.1021/jacs.5c20309. Online ahead of print. ABSTRACT Described is the use of photocatalytic and enzymatic activation of rapid bioorthogonal chemistry for cell surface proximity labeling. Current approaches to proximity labeling rely on the activation of reactive intermediates (e.g., carbenes, nitrenes, radicals, electrophiles), whose… Read more: Tunable Cell Surface Proximity Labeling via Photocatalytic and Enzymatic Activation of Fast Bioorthogonal Chemistry

Chem Commun (Camb). 2026 Apr 24. doi: 10.1039/d6cc00317f. Online ahead of print. ABSTRACT Biodegradable plastics are materials that can be decomposed by the action of microbes into water, CO2, and biomass. They are attractive materials to solve the issue of serious environmental pollution due to plastic disposal. Some biodegradable plastics… Read more: CO2-based biodegradable plastics and their precursor production using photo-biocatalytic processes

J Mater Chem B. 2026 Apr 16. doi: 10.1039/d6tb00112b. Online ahead of print. ABSTRACT A high-performance organic photoelectrochemical transistor (OPECT) sensor was successfully constructed based on a ZnCdS/Ce-MOF composite gate integrated with a self-replicating catalytic hairpin assembly (SRCHA) signal-amplification strategy, which enables ultrasensitive and highly selective detection of the pesticide… Read more: A cascade-functionalized ZnCdS/Ce-MOF composite gate coupled with a self-replicating catalytic hairpin assembly for OPECT sensing of imidacloprid

Angew Chem Int Ed Engl. 2026 Apr 10:e9334343. doi: 10.1002/anie.9334343. Online ahead of print. ABSTRACT Dynamic sub-compartmentalization and internal organization are important assets of living cells to control functional complexity. Mimicking these features in artificial cells provides a platform to effectively respond to external cues by changing internal structure, thereby… Read more: Reconfiguration of Multiphase Coacervate Droplets Into Self-Regulated Nested Artificial Cells

Res Sq [Preprint]. 2026 Apr 3:rs.3.rs-9204910. doi: 10.21203/rs.3.rs-9204910/v1. ABSTRACT Stereoselective nucleophilic substitution to access α tertiary amines relies on copper catalyzed radical approaches in which the substitution is mediated by metal-anilide coordination.1 These systems, however, are constrained by competing arene radical alkylation pathways.2 Here we report a distinct photoenzymatic mechanism… Read more: Biocatalytic Radical C(sp³)-N Coupling via Active Site Templating

Chemphyschem. 2026 Apr 14;27(7):e202500905. doi: 10.1002/cphc.202500905. ABSTRACT Krokinobacter eikastus rhodopsin 2 (KR2) is a microbial light-driven ion pump that transports Na+ out of the cell. The active transport is coupled to a photocycle of the retinal chromophore, covalently attached to the protein via a Schiff base linkage. In this work,… Read more: The Conformational Switches of a Bacterial Light-Driven Sodium Pump Characterized by Time-Resolved Resonance Raman Spectroscopy

Chem Catal. 2026 Feb 19;6(2):101607. doi: 10.1016/j.checat.2025.101607. ABSTRACT Vitamin B12 (VB12), one of nature’s most versatile cofactors, performs a multitude of radical and polar steps carefully choreographed by its surrounding enzyme microenvironment. It is highly desirable to capture this variegated reactivity in synthetic applications as well; however, few design principles… Read more: Controlling divergent hydrogen atom transfer in Vitamin B12-photocatalyzed oxetane ring opening

RSC Adv. 2026 Apr 7;16(20):17972-17982. doi: 10.1039/d6ra01041e. eCollection 2026 Apr 1. ABSTRACT A visible-light-driven photoredox protocol for the α-amino C(sp3)-H heteroarylation of N-aryl pyrrolidines and piperidines with 2-chlorobenzothiazole derivatives in batch and in flow conditions is developed. The transformation proceeds under mild conditions using an iridium photocatalyst in the presence… Read more: Photoredox-enabled late-stage functionalization of pyrrolidines in batch and flow: rapid access to benzothiazole hybrids as a new class of cholinesterase inhibitors

J Am Chem Soc. 2026 Apr 8. doi: 10.1021/jacs.6c00570. Online ahead of print. ABSTRACT Photoenzymatic reduction of CO2 to formate is a promising strategy for carbon valorization, yet its efficiency is still limited by inefficient energy and mass transport. Here, we design a series of isostructural hydrogen-bonded organic frameworks (HOFs)… Read more: Regulation of Energy and Mass Transport in a Hydrogen-Bonded Framework for Visible-Light-Driven CO(2) Reduction in Water

Small. 2026 Apr 5:e73308. doi: 10.1002/smll.73308. Online ahead of print. ABSTRACT In nature, photocatalytic reduction of carbon dioxide is a critical process for maintaining the global carbon cycle, which is initiated by the enzymes consisting of chromophoric organic macrocycles in the presence of water. It is extremely desirable to develop… Read more: Bipyrimidine-Boosted Preparation and Post-Functionalization of Vinylene-Linked Covalent Organic Frameworks for Sacrificial-Agent-Free Photocatalysis of CO(2) Reduction

Nat Commun. 2026 May 2. doi: 10.1038/s41467-026-72534-1. Online ahead of print. ABSTRACT Enzymes can exist in multiple stable functional states or sub-states, revealing substantial molecule-to-molecule heterogeneity in catalytic rates even within populations expressed from a clonal gene. Increasing evidence suggests that biological systems have evolved to exploit these functional… Read more: Single-molecule kinetic exploration of functional sub-states in an evolving phosphotriesterase

ACS Catal. 2026 Mar 30;16(8):7669-7682. doi: 10.1021/acscatal.6c00759. eCollection 2026 Apr 17. ABSTRACT Large language models (LLMs) have demonstrated their limitations in addressing the design of active proteins that rely on intricate intramolecular interactions, particularly in the engineering of biocatalysts. Conducting real-world studies from targeted laboratory assays has become the… Read more: Generative Artificial Intelligence-Empowered Virtual Evolution of Enzyme with the VERnet Model

Biotechnol Adv. 2026 Apr 8:108895. doi: 10.1016/j.biotechadv.2026.108895. Online ahead of print. ABSTRACT Evolutionary engineering is a key strategy for obtaining industrial strains with high stress tolerance and productivity, as well as improving enzyme performance. However, low natural mutation rates, small in vitro mutation libraries, and lengthy phenotypic screening cycles… Read more: Advances in in vivo continuous evolution technologies for strain development and enzyme engineering

Front Microbiol. 2026 Feb 27;17:1754802. doi: 10.3389/fmicb.2026.1754802. eCollection 2026. ABSTRACT Extremophiles are microorganisms that thrive in environments previously thought to be uninhabitable, including extreme temperature, salinity, pH, pressure, and radiation. These organisms, found in Archaea, Bacteria, and Eukarya, exhibit distinct structural, metabolic, and genetic adaptations, such as enhanced enzyme… Read more: Molecular adaptations and engineering of extremophiles for synthetic biology and biotechnological applications

Nat Commun. 2026 Feb 19;17(1):2945. doi: 10.1038/s41467-026-69706-4. ABSTRACT C-prenylated flavonoids possess notable pharmaceutical potential, but their production is hindered by the challenging selective prenylation of their unstable polyphenolic cores. Natural prenyltransferases offer a direct route but suffer from low activity and incomplete mechanistic understanding. Here, we report a directed… Read more: Tuning aromatic cage occupancy in prenyltransferases enables selective and efficient production of rare c-prenylated flavonoids

Plant Biotechnol J. 2026 Feb 19. doi: 10.1111/pbi.70592. Online ahead of print. ABSTRACT Iridoids constitute a prominent class of plant-specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate-specific carboxyl methyltransferases-GjGAMT and CrLAMT-that catalyse the decisive… Read more: The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Plant Biotechnol J. 2026 Mar 14. doi: 10.1111/pbi.70612. Online ahead of print. ABSTRACT Belamcanda chinensis is a non-leguminous medicinal plant rich in bioactive isoflavones; however, the lack of a high-quality reference genome has limited elucidation of its isoflavone biosynthetic and modification network. Here, we present the first near telomere-to-telomere… Read more: A Near Telomere-to-Telomere Genome of Belamcanda chinensis Provides Insights Into Genome Evolution and the Biosynthesis of Characteristic Isoflavones

ACS Synth Biol. 2026 Feb 20;15(2):534-547. doi: 10.1021/acssynbio.5c00630. Epub 2026 Feb 2. ABSTRACT Antibiotic resistance is escalating, highlighting the urgent need for novel antimicrobial strategies. Defensin-like antimicrobial peptides (AMPs) are considered ideal candidates due to their broad-spectrum activity and engineerable potential; however, their limited antimicrobial efficacy and complex chemical… Read more: Rational Engineering and Biosynthesis of Defensin-Derived Antimicrobial Peptides with Broad-Spectrum and Potent Activity

Int J Biol Macromol. 2026 Feb;347:150779. doi: 10.1016/j.ijbiomac.2026.150779. Epub 2026 Feb 5. ABSTRACT Inorganic pyrophosphatases (PPases) catalyze the hydrolysis of inorganic pyrophosphate (PPi) into orthophosphate (Pi) in the presence of magnesium ions, thereby driving diverse biosynthetic processes. They have been widely applied in in vitro transcription, PCR, and sequencing… Read more: Biochemical characterization and identification of catalytic residues of the thermostable inorganic pyrophosphatase from Thermococcus litoralis

Proc Natl Acad Sci U S A. 2026 Feb 17;123(7):e2529018123. doi: 10.1073/pnas.2529018123. Epub 2026 Feb 9. ABSTRACT Cross-couplings are essential reactions in modern chemical synthesis, enabling the rapid construction of complex molecules from simple precursors. Transition metal catalysts are prized for these transformations because their reactivity and selectivity can… Read more: Photoenzymatic Csp(3)-Csp(3) bond formation via enzyme-templated radical-radical coupling

J Am Chem Soc. 2026 May 4. doi: 10.1021/jacs.6c05845. Online ahead of print. ABSTRACT Stereochemically defined all-carbon tetrasubstituted alkenes are key structural motifs in various bioactive compounds and organic materials. Owing to the congested nature of the carbon-carbon double bond, controlling regio- and stereochemistry still remains a crucial challenge in… Read more: Stereoreversed C-O Activation Unlocks All-Carbon Tetrasubstituted <em>Z</em>-Alkene Synthesis

Small. 2026 May 3:e73631. doi: 10.1002/smll.73631. Online ahead of print. ABSTRACT The heterogenization of homogeneous catalysts represents a major research direction in modern green catalysis, as it combines the high activity and selectivity features of molecular catalysts with the high stability and facile recyclability benefits of solid materials. A common… Read more: Heterogenization of Fe3+ Ions on Chiral Carbon Dots With Enhanced Activity and Stability in DOPA Oxidation

Carbohydr Polym. 2026 Jul 1;383:125341. doi: 10.1016/j.carbpol.2026.125341. Epub 2026 Apr 19. ABSTRACT The rational use of carbohydrate polymers as functional matrices for integrating inorganic and organic components remains a key challenge in developing sustainable multifunctional materials. Here, a process-oriented, bio-inspired strategy for fabricating a chitosan-centred multifunctional composite coating is presented.… Read more: Chitosan-TiO2-curcumin composite coatings: Toward nature-inspired, protective and sustainable silk materials

Angew Chem Int Ed Engl. 2026 Apr 20:e5931335. doi: 10.1002/anie.5931335. Online ahead of print. ABSTRACT The Au(I)-catalyzed asymmetric cascade cyclization of yne-enones/addition represents a powerful strategy for constructing furan skeletons; however, the use of enol-type carbon nucleophiles in this transformation remains a considerable challenge. In this study, we report the… Read more: A Chiral Multifunctional Phosphine Ligand for Gold-Catalyzed Diastereo- and Enantioselective Cyclization of Yne-enones/Enol-Addition

Mater Horiz. 2026 Apr 16. doi: 10.1039/d6mh00036c. Online ahead of print. ABSTRACT Iridium oxide (IrOx) has emerged as a prominent catalyst for the acidic oxygen evolution reactions (OER). However, its direct preparation on the surface of Ir is rare, severely restricting its applications in catalysis and sensing technologies. In this… Read more: Friction-assisted electrochemical oxidation of iridium surfaces for enhanced catalysis

J Am Chem Soc. 2026 Apr 15. doi: 10.1021/jacs.6c04486. Online ahead of print. ABSTRACT The proton-electron transfer (PET) reaction is a fundamental pathway in redox catalysis that drives critical processes from enzymatic reactions to sustainable fuel generation. Yet its efficient implementation in heterogeneous systems often necessitates liquid-phase molecular mediators, which… Read more: Direct Synthesis of Pure Aqueous H2O2 Solutions Catalyzed by C60-Buffered Proton-Electron Transfer on Palladium Adatoms

Org Lett. 2026 Apr 10. doi: 10.1021/acs.orglett.6c01268. Online ahead of print. ABSTRACT Isoindolinones are valuable nitrogen-containing heterocycles, yet efficient access to highly functionalized derivatives remains challenging. Herein, we report a bioinspired carbonyl alkylative amination enabled by Ca(II)/HFIP cooperative catalysis for the modular synthesis of 3-alkyl-N-substituted isoindolinones. This three-component cascade combines… Read more: Bioinspired Alkyl Transfer Enabled by Ca(II)/HFIP Cooperative Catalysis: Modular Synthesis of Functionalized Isoindolinones

Adv Mater. 2026 Apr 10:e23689. doi: 10.1002/adma.202523689. Online ahead of print. ABSTRACT Chirality is a fundamental property with profound implications in fields like pharmaceuticals, yet the separation of enantiomers remains a significant technical hurdle. This review chronicles the development of interfacial super-assembled hetero-structured chiral nanochannel membranes, a transformative approach for… Read more: Interfacial Super-Assembled Hetero-Structured Chiral Nanochannels for Enantioseparation Applications

ACS Nano. 2026 Apr 8. doi: 10.1021/acsnano.6c00940. Online ahead of print. ABSTRACT The tandem strategy for electrochemical CO2 reduction (ECO2R), which utilizes CO gas as the essential intermediate, offers a promising route for converting CO2 into multicarbon (C2+) products. However, inefficient retention and utilization of the CO intermediate remain fundamental… Read more: Carbon Nanotube CO Reservoir Enables Efficient Tandem CO2 Electroreduction to Multicarbon Products with >1 A cm-2 Partial Current Density

ChemSusChem. 2026 Apr 14;19(7):e202502322. doi: 10.1002/cssc.202502322. ABSTRACT The design and development of bioinspired coordination compounds are crucial for laying the foundation to deliver low-cost, energy-efficient materials that promote energy sustainability. In this work, isostructural copper complexes, Cu-LN2S2 and Cu-LN3S, in tune with the donor centers in the ligand backbone, (LN2S2… Read more: Bioinspired Copper(II) Complexes With N,S-Donor Ligands: Structure-Activity Relationships and Mechanistic Insights for Aqueous Hydrogen Evolution Reaction

J Pharm Sci. 2026 Apr 29:104303. doi: 10.1016/j.xphs.2026.104303. Online ahead of print. ABSTRACT Recent advances in bispecific agents targeting both CD19 and CD20 highlight their potential as an effective strategy for improving clinical outcomes in B-cell malignancies. Herein, we developed a CD19/CD20 bispecific nanobody, 19Nb1-20Nb2, by fusing the anti-CD19 nanobody… Read more: Chemoenzymatic synthesis of a CD19/CD20 bispecific nanobody-rhamnose conjugate with reconstituted Fc effector functions for immunotherapy of B-cell malignancies

J Am Chem Soc. 2026 Apr 29. doi: 10.1021/jacs.6c06067. Online ahead of print. ABSTRACT Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, preventing further research regarding their biological function. In biosynthesis, oxidases from… Read more: Chemoenzymatic Synthesis with Plant Oxidases and Metabolic Engineering Enable Rapid Access to Rare Gibberellins

Org Biomol Chem. 2026 Apr 23. doi: 10.1039/d6ob00328a. Online ahead of print. ABSTRACT The magic spot nucleotides (MSNs), (p)ppGpp and (p)ppApp, play central roles in bacterial stress signaling, yet their selective detection and chemical accessibility remain limited. This work presents a scalable chemo-enzymatic synthesis of natural and functionalized pentaphosphorylated MSNs… Read more: Pentaphosphorylated magic spot nucleotides: chemoenzymatic synthesis and disassembly-based sensing

J Am Chem Soc. 2026 Apr 22. doi: 10.1021/jacs.6c03530. Online ahead of print. ABSTRACT Electroenzymatic synthesis, merges the versatility of electrocatalysis with the specificity of enzymology, offering a sustainable strategy for chemical manufacturing. However, the practical application of this approach is often limited by inefficient and incompatible electron transfer between… Read more: Electroenzymatic C1 Fixation to Glycine via Dithiothreitol Regeneration on Functionalized 1T’-MoS2

Org Lett. 2026 Apr 17. doi: 10.1021/acs.orglett.6c00887. Online ahead of print. ABSTRACT The availability of an effective ene-reductase (ER) for the synthesis of Sacubitril intermediates represents a major challenge. Herein, we report the engineering of ClER and GoER utilizing three different substrates to synthesize the key Sacubitril precursor. The best… Read more: Engineering Ene-Reductases for the Chemoenzymatic Synthesis of a Sacubitril Intermediate and Its Derivatives

Molecules. 2026 Apr 7;31(7):1216. doi: 10.3390/molecules31071216. ABSTRACT Selective protein terminal labeling has become essential for system-wide studies of proteolytic mechanisms in disease. These methods enable precise tracking of cleavage dynamics, protease interactions, and cellular networks, offering transformative potential for proteolytic event analysis. This review explores recent advances in N-/C-terminal modification… Read more: Exploiting Selective Position Labeling to Unveil the Hidden Complexity of Terminomics

Org Lett. 2026 Apr 13. doi: 10.1021/acs.orglett.6c00937. Online ahead of print. ABSTRACT Triazolopyridines are an important class of heterocycles in the pharmaceutical industry and materials sciences. In particular, [1,2,3]triazolo[1,5a]pyridines have emerged as stable and versatile diazo compound precursors for performing carbene-mediated transformations. Despite their wide range of applications in chemical… Read more: Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases

ACS Chem Biol. 2026 Apr 11. doi: 10.1021/acschembio.6c00132. Online ahead of print. ABSTRACT Ufmylation is a newly identified ubiquitin-like modification of histones and plays important roles in DNA-related processes. Dissecting histone ufmylation pathways necessitates the use of chemically defined proteins to assign their structural and functional consequences; however, the preparation… Read more: Expedient Chemical Synthesis of Ufmylated Histones Using Chemoenzymatic C-Terminal Hydrazinolysis of Ubiquitin-Fold Modifier 1

Biomacromolecules. 2026 Apr 11. doi: 10.1021/acs.biomac.5c02511. Online ahead of print. ABSTRACT Resilin, an elastic protein found in insect cuticles, is exceptionally resilient because of its amino acid sequence and dityrosine cross-linking. In this study, the chemoenzymatic synthesis of resilin-mimetic polypeptides based on minimal peptide motifs incorporating glycine, proline, serine, and… Read more: Resilin-Mimetic Copolypeptides from Minimal Motifs: A Chemoenzymatic and Bioinspired Circular Design for Sustainable Bioelastic Materials

Chembiochem. 2026 Apr 14;27(7):e202500972. doi: 10.1002/cbic.202500972. ABSTRACT Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a well-established target for lowering cholesterol and is abundantly present in the extracellular space. Inhibitors of PCSK9 have achieved marked success in the clinic, but an alternative strategy for therapeutic modulation is emerging through the degradation… Read more: Enzyme-Assisted Synthesis and In Vitro Characterization of Bifunctional PCSK9 Inhibitors