BioCat Collective

Zhongguo Zhong Yao Za Zhi. 2026 Aug;51(16):4623-4633. doi: 10.19540/j.cnki.cjcmm.20260330.401. ABSTRACT Coumarins mainly include simple coumarins, furanocoumarins, and pyranocoumarins. These compounds exhibit diverse biological activities, including anticoagulant, antibacterial, antitumor, and antioxidant effects, and thus possess high value for drug development. At present, coumarins are mainly obtained through traditional plant extraction methods.… Read more: Pharmacological effects, biosynthesis, and production of coumarin compounds: a review

ACS Appl Mater Interfaces. 2026 Sep 1. doi: 10.1021/acsami.6c11728. Online ahead of print. ABSTRACT Pigments are widely utilized in industries; however, conventional synthetic pigment production relies on petroleum-based feedstocks, consumes significant energy, and involves toxic chemicals. Although natural pigments provide a sustainable alternative, these systems are constrained by seasonal variability,… Read more: Living Whole-Cell Biocatalysis for Sustainable and Durable Melanin-Based Textile Coloration

ACS Appl Bio Mater. 2026 Sep 2. doi: 10.1021/acsabm.6c00770. Online ahead of print. ABSTRACT Proteases cleave peptide bonds and generate shorter polypeptide products, finding broad applications. For applications in peptide sequencing, protein mapping, and production of bioactive polypeptides, control over where proteolysis initiates and how it proceeds is critical. Natural… Read more: Ca-BPDC Immobilization Redistributes Regional Proteolytic Preference of Serine Proteases

J Agric Food Chem. 2026 Sep 2;74(34):27168-27178. doi: 10.1021/acs.jafc.6c07461. ABSTRACT Rhamnosyltransferases are remarkable biocatalysts for the synthesis of rhamnosylated natural products with valuable physicochemical properties and bioactivities. However, their application is hindered by poor stability and low catalytic efficiency. Here, we achieved simultaneous enhancement of catalytic efficiency and stability of… Read more: Reshaping the Activity-Stability Landscape of a 1,2-Rhamnosyltransferase via Distal Mutational Engineering

Langmuir. 2026 Sep 1;42(34):25110-25120. doi: 10.1021/acs.langmuir.6c03108. ABSTRACT Biodesulfurization offers an energy-efficient alternative to conventional hydrodesulfurization, but its industrial efficiency is severely bottlenecked by the low bioaccessibility of hydrophobic substrates across the oil-water interface. Here, we addressed this mass-transfer challenge using exogenous-surfactant-free water-in-oil Pickering emulsions stabilized solely by Gordonia sp. WQ-01A… Read more: Kinetic Intensification of Interfacial Biodesulfurization via Self-Assembled Whole-Cell Pickering Emulsions

PLoS One. 2026 Sep 2;21(9):e0355285. doi: 10.1371/journal.pone.0355285. eCollection 2026. ABSTRACT With the increasing detection of emerging pollutants (EPs), such as pharmaceuticals, personal care products, and pesticides, in water bodies, there is a growing research priority to develop efficient methods for their degradation. In the present study, the degradation of 21… Read more: Immobilized horseradish peroxidase hybrid biocatalysts for degradation of pharmaceuticals and other emerging micropollutants

Pharm Res. 2026 Sep 3. doi: 10.1007/s11095-026-04178-1. Online ahead of print. ABSTRACT PURPOSE: Synthetic peptide test products referencing recombinant-origin products present unique regulatory challenges in demonstrating higher-order structural (HOS) comparability beyond primary sequence sameness. Liraglutide, a lipidated glucagon-like peptide-1 (GLP-1) receptor agonist with defined self-association behavior, represents an important model… Read more: An Orthogonal Framework for Higher-Order Structural and In Vitro Functional Comparability of Chemically Synthesized Liraglutide Relative to an rDNA-Origin Reference Product

Turk J Chem. 2026 Jun 9;50(4):386-400. doi: 10.55730/1300-0527.3904. eCollection 2026. ABSTRACT This study involved the immobilization of acetylcholinesterase (AChE) onto a natural thin membrane extracted from the inner epidermal layer of Allium cepa, with the aim of enhancing the enzyme’s stability, activity, and reusability for potential biotechnological applications. The membrane,… Read more: Acetylcholinesterase immobilization on a natural thin membrane for stable biocatalyst design

Nucleic Acids Res. 2026 Aug 24;54(16):gkag865. doi: 10.1093/nar/gkag865. ABSTRACT Prokaryotic Argonautes (pAgos) are widely distributed and provide immunity against invading DNA. Based on their domain architecture, pAgos are classified into three major groups: long-A, long-B, and short pAgos. Among them, long-B pAgos remain the least understood subgroup. Here, we show… Read more: Mechanism of the long-B prokaryotic Argonaute-mediated nuclease activation in bacterial immunity

RSC Adv. 2026 Sep 1. doi: 10.1039/d6ra05475g. Online ahead of print. ABSTRACT In the field of medicinal chemistry, the design of small molecules is acknowledged as an effective strategy. This study may contribute to the global fight against inflammatory diseases by focusing on the synthesis of novel α-aminophosphonate derivatives incorporating… Read more: Synthesis, X-ray structures and biological evaluation of novel α-aminophosphonate derivatives as anti-inflammatory and antioxidant agents: an integrated <em>in vitro</em> and <em>in silico</em> study

Front Microbiol. 2026 Aug 18;17:1891602. doi: 10.3389/fmicb.2026.1891602. eCollection 2026. ABSTRACT Natural products are a crucial source for drug discovery, but their traditional development is limited by resource availability, efficiency, chemical complexity, and the difficulty of rapidly diversifying biologically active scaffolds. This review addresses the central question of how biosynthetic precision… Read more: Engineered strains as living factories: efficient biosynthesis and modification of natural products via synthetic biology and one-pot chemical tandem reactions

Methods Mol Biol. 2026;3032:17-24. doi: 10.1007/978-1-0716-5257-2_2. ABSTRACT Photoenzymatic catalysis offers a novel methodology to control chemoselectivities and enantioselectivities in photochemistry and biocatalysis, is establishing its standing as an emerging frontier in synthetic chemistry. Herein, we describe a fundamental experimental protocol for preparing and purifying enzymes form Escherichia coli BL21(DE3), including… Read more: New-to-Nature Photoenzymatic Catalysis

Methods Mol Biol. 2026;3032:47-67. doi: 10.1007/978-1-0716-5257-2_4. ABSTRACT Photobiocatalysis, an interdisciplinary frontier integrating chemistry, biology, and catalysis, drives enzymatic catalysis from natural reactions to new-to-nature transformations via protein engineering and photochemistry. This review centers on enzyme classes, covering nine key families: fatty acid photodecarboxylases (FAPs), nicotinamide-dependent reductases, flavin-dependent “ene”-reductases (EREDs), and… Read more: Designing and Engineering Enzymes for New-to-Nature Photobiocatalysis

Chemistry. 2026 Sep 2:e71544. doi: 10.1002/chem.71544. Online ahead of print. ABSTRACT The difructose dianhydride I synthase/hydrolase α FFase 1 catalyzes the reversible transformation of inulobiose into difructose dianhydride I, a component of caramel. The proposed reaction mechanism of such a transformation consists of a glycosylation step followed by a cyclization… Read more: GH172 Difructose Dianhydride I Synthase: A Two-Stepped Journey via Glycosylation and Cyclization Using QM/MM Metadynamics

J Agric Food Chem. 2026 Aug 26;74(33):26057-26070. doi: 10.1021/acs.jafc.6c06845. ABSTRACT Pectate lyases are promising industrial biocatalysts, but limited thermostability restricts their practical use. Here, we developed a multidimensional consensus computational framework integrating sequence conservation, structural dynamics, and thermodynamic prediction to identify functional mutation hotspots in PcPel1834. Iterative saturation mutagenesis yielded… Read more: Multidimensional Computational Engineering of Pectate Lyase for Enhanced Thermostability and Moderately Improved Catalytic Efficiency

ACS Nano. 2026 Sep 1;20(34):23893-23906. doi: 10.1021/acsnano.6c07948. ABSTRACT Direct solar-to-chemical conversion offers a compelling route to clean, dispatchable energy. Photosystem I (PSI), an evolutionarily optimized light-driven oxidoreductase, can be repurposed for solar-fuel production by coupling its photochemistry to catalytic interfaces. However, the molecular determinants that govern productive electron transfer to… Read more: Molecular Design Principles for Photosystem I-Based Biohybrid Solar Fuel Catalysts

Nat Commun. 2026 Aug 5;17(1):9427. doi: 10.1038/s41467-026-76316-7. ABSTRACT Light-dependent protochlorophyllide oxidoreductase (LPOR) is a light-driven enzyme in flowering plants. It is involved in chlorophyll biosynthesis while also reorganizing membrane lipids into the cubic membrane network that supports chloroplast development. However, the structural basis of these two activities and their relationship… Read more: Structures of LPOR-Chlide complexes reveal the structural basis of membrane remodeling and photocatalysis

Small. 2026 Sep 2:e75590. doi: 10.1002/smll.75590. Online ahead of print. ABSTRACT Oscillatory fluid flows underpin transport, mixing, and signal propagation in living systems, yet artificial microfluidic platforms rely almost extensively on external power or chemically driven gradients to reproduce such dynamics. Here, we introduce a fuel-free strategy based on photo-mechanical… Read more: Photoactuated Micropumps Enable Oscillatory Fluidics and Autonomous Locomotion

Methods Mol Biol. 2026;3032:47-67. doi: 10.1007/978-1-0716-5257-2_4. ABSTRACT Photobiocatalysis, an interdisciplinary frontier integrating chemistry, biology, and catalysis, drives enzymatic catalysis from natural reactions to new-to-nature transformations via protein engineering and photochemistry. This review centers on enzyme classes, covering nine key families: fatty acid photodecarboxylases (FAPs), nicotinamide-dependent reductases, flavin-dependent “ene”-reductases (EREDs), and… Read more: Designing and Engineering Enzymes for New-to-Nature Photobiocatalysis

Methods Mol Biol. 2026;3032:47-67. doi: 10.1007/978-1-0716-5257-2_4. ABSTRACT Photobiocatalysis, an interdisciplinary frontier integrating chemistry, biology, and catalysis, drives enzymatic catalysis from natural reactions to new-to-nature transformations via protein engineering and photochemistry. This review centers on enzyme classes, covering nine key families: fatty acid photodecarboxylases (FAPs), nicotinamide-dependent reductases, flavin-dependent “ene”-reductases (EREDs), and… Read more: Designing and Engineering Enzymes for New-to-Nature Photobiocatalysis

Angew Chem Int Ed Engl. 2026 Aug 28:e5856873. doi: 10.1002/anie.5856873. Online ahead of print. ABSTRACT Light-driven photoredox catalysis can shift intracellular NADH/NAD+ balance by oxidizing NADH, but intracellular NADH pools are dynamically replenished through enzyme-coupled redox metabolism. We show that ALDH-mediated restoration of NADH/NAD+ balance can buffer photoredox-induced NADH depletion,… Read more: ALDH Inhibition-Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Nature. 2026 Jul 27. doi: 10.1038/s41586-026-10930-9. Online ahead of print. ABSTRACT Non-native photoenzymes have enabled myriad asymmetric bond-forming events that are otherwise challenging or at present impossible with small-molecule catalysis1,2. These reactions require enzymes with cofactors that are strong absorbers in the visible region with reasonably long-lived excited states, such… Read more: Pyridoxal photoenzymes for asymmetric radical-radical cross-couplings

Molecules. 2026 Aug 13;31(16):2830. doi: 10.3390/molecules31162830. ABSTRACT A light-promoted C-H/C-H coupling of imidazo[1,2-a]pyridines with 5-(hetero)aryl-1,2,5-oxadiazolo[3,4-b]pyrazines was developed using a heterogeneous oxidative photocatalytic system based on molecular oxygen, nanosized TiO2, and light irradiation. The method provides direct access to C3-heteroarylated imidazo[1,2-a]pyridines under metal-free conditions and expands the synthetic utility of electron-deficient… Read more: Light-Promoted C-H/C-H Coupling of Imidazo[1,2-<em>a</em>]pyridines with 5-(Hetero)aryl-1,2,5-oxadiazolo[3,4-<em>b</em>]pyrazines over TiO2 and Experimental/In Silico Evaluation of COX-1 and COX-2 Inhibitory Activity

Angew Chem Int Ed Engl. 2026 Aug 25:e8631704. doi: 10.1002/anie.8631704. Online ahead of print. ABSTRACT Photocatalytic NADH regeneration is limited by poor recovery of the rhodium mediator (Rh*) and enzyme deactivation caused by free Rh* species and photogenerated holes. In this study, we introduce poly(acrylic acid) brushes grafted onto conjugated… Read more: Conjugated Microporous Polymers Bearing Poly(Acrylic Acid) Brushes: Site-Specific Rhodium Immobilization for Efficient and Enzyme-Compatible Photocatalytic NADH Regeneration

Angew Chem Int Ed Engl. 2026 Aug 19:e5014162. doi: 10.1002/anie.5014162. Online ahead of print. ABSTRACT Biotin-streptavidin artificial metalloenzymes (ArMs) provide a platform to integrate transition-metal catalysis within a protein-defined microenvironment. Traditional indolone syntheses often rely on transition metal catalysts, high temperatures, and strong oxidants, limiting functional-group tolerance, and sustainability. In… Read more: Iridium Artificial Metalloenzymes Enabled Photo-Enzymatic Radical Indolone Synthesis

Molecules. 2026 Jul 28;31(15):2626. doi: 10.3390/molecules31152626. ABSTRACT The chronic overuse of antibiotics has accelerated the emergence of antibiotic-resistant bacteria, creating a global public health crisis as conventional therapies fail against multidrug-resistant pathogens spreading through water and food chains. Cadmium sulfide (CdS) has been established as an important visible-light-driven photocatalyst for… Read more: CdS-Based Photocatalysts for Antimicrobial Applications: From Quantum Dots to Z-Scheme Heterojunctions-Mechanisms, Challenges, and Future Perspectives

J Am Chem Soc. 2026 Aug 12;148(31):33757-33766. doi: 10.1021/jacs.6c11128. ABSTRACT We report a tetrazine-regulated in situ hydrazine release strategy to synthesize highly crystalline azine-linked COFs (AZ-COFs) with varied central cores (triazine, cyanuric acid, benzene). The slow hydrolysis of 3,6-dimethyl-1,2,4,5-tetrazine enables controlled hydrazine generation, allowing kinetically moderated azine formation and overcoming… Read more: Tetrazine-Regulated Synthesis of Azine-Linked Covalent Organic Frameworks for Photocatalytic Cofactor Regeneration and Photoenzymatic Catalysis

J Hazard Mater. 2026 Aug 10;515:143227. doi: 10.1016/j.jhazmat.2026.143227. Online ahead of print. ABSTRACT To address the challenge of simultaneously achieving efficient removal, enhanced mineralization, and risk mitigation of dimethyl phthalate (DMP), a multifunctional sodium alginate (SA) microbead platform integrating photocatalysis, enzymatic catalysis, and magnetic recovery was developed. A CeO2@Bi2WO6 heterojunction… Read more: Interfacial photo-enzyme coupled on sodium alginate microbeads co-immobilizing lipase and CeO(2)@Bi(2)WO(6) heterojunction for stepwise degradation of dimethyl phthalate

Luminescence. 2026 Aug;41(8):e70600. doi: 10.1002/bio.70600. ABSTRACT Zinc oxide nanoparticles (ZnO NPs) were successfully synthesized via an eco-friendly green route using aqueous leaf extract of Sonchus wightianus as a natural reducing and capping agent. UV-Vis spectroscopy revealed a characteristic absorption peak at 267 nm, with a direct optical band gap of… Read more: Plant-Mediated Synthesis of ZnO Nanoparticles From Sonchus wightianus: Physicochemical Characterization and Evaluation of Photocatalytic, Antibiofilm, and Antioxidant Potential

Angew Chem Int Ed Engl. 2026 Aug 5:e5802081. doi: 10.1002/anie.5802081. Online ahead of print. ABSTRACT Photocatalytic hydrogen peroxide (H2O2) synthesis via oxygen reduction reaction (ORR) offers a sustainable alternative to energy-intensive anthraquinone processes. However, its efficiency is hindered by poor selectivity and instability stemming from reactive superoxide intermediates through the… Read more: Induced-Fit for Oxygen Adsorption: Flexible Conjugated Microporous Polymers With Self-Adaptive Active Sites for H2O2 Photosynthesis

Nat Commun. 2026 Jul 25;17(1):9044. doi: 10.1038/s41467-026-75811-1. ABSTRACT Herbicides in combination with genetically modified herbicide-resistant crops have revolutionized modern weed management, increased crop yields, and facilitated farming practices. However, rapid evolution of herbicide-resistant weeds necessitates new resistance traits to sustain control efficacy. Here, we introduce a terminal carboxyl anchoring mechanism-inspired… Read more: Anchoring mechanism-inspired discovery of a bacterial P450 gene conferring resistance to auxin herbicides

J Struct Biol X. 2026 Jul 31;14:100156. doi: 10.1016/j.yjsbx.2026.100156. eCollection 2026 Dec. ABSTRACT Allosteric regulation in biosynthetic L-threonine deaminase (BTD) has long been attributed to effector-induced conformational changes. Here, we identify a trans-interface coupling mechanism that regulates the active site architecture of EcIlvA, the BTD homolog of Escherichia coli. Starting… Read more: Trans-interface coupling in the tetrameric enzyme underlies allosteric control in Escherichia coli biosynthetic threonine deaminase

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

J Exp Bot. 2026 Jul 16:erag350. doi: 10.1093/jxb/erag350. Online ahead of print. ABSTRACT Flavonoids, a class of phenolic compounds widely distributed throughout the plant kingdom, exhibit extensive physiological and pharmacological properties. Chalcone synthase (CHS), the key and rate-limiting gateway enzyme in flavonoid biosynthesis, catalyzes the condensation reaction between malonyl-CoA and… Read more: Chalcone Synthase: From Discovery to Biotechnological Applications

J Am Chem Soc. 2026 Jul 17. doi: 10.1021/jacs.6c06323. Online ahead of print. ABSTRACT Developing enzymatic mechanisms for C-F bond formation remains a long-standing challenge. Here, we repurposed the biosynthetic nonheme Fe enzyme EgtB, which features a three-histidine facial triad, to catalyze C(sp3)-H fluorination reactions. Directed evolution of EgtB afforded… Read more: Influence of Primary Coordination Sphere on Anion Rebound Selectivity in Nonheme Fe Enzyme-Catalyzed C(sp(3))-H Functionalization: A Comparative Experimental and Computational Study of EgtB and ACCO

ChemSusChem. 2026 Sep 14;19(17):e71010. doi: 10.1002/cssc.71010. ABSTRACT Nature relies on multifunctional microenvironments to combine substrate recognition, activation, and catalysis with remarkable efficiency. Inspired by this principle, we report heterogeneous synzymes generated by the supramolecular immobilization of pseudopeptidic zinc macrocyclic complexes onto UiO-67 for CO2 activation and valorization. The zinc chiral… Read more: Bioinspired Zinc Macrocycles Confined in UiO-67: A Heterogeneous Synzyme for Sustainable CO(2) Valorization

Adv Mater. 2026 Aug 27:e74827. doi: 10.1002/adma.74827. Online ahead of print. ABSTRACT Flavin-dependent monooxygenases (FMOs) catalyze redox reactions central to antibiotic degradation and metabolic detoxification, yet replicating their intricate cofactor-dependent electron transfer in synthetic systems has remained elusive. Here, we report an electronic modulation strategy that enables cofactor-free FMO-like catalysis… Read more: Entropy-Encoded Electronic Reconstruction in High-Entropy Nanozymes Enables Cofactor-Free Monooxygenase-Like Catalysis

JACS Au. 2026 Jul 19;6(8):4353-4366. doi: 10.1021/jacsau.6c00663. eCollection 2026 Aug 24. ABSTRACT Confined spaces at the nanoscale  pores, channels, and cavities that alter molecular affinities and restrict molecular motion, orientation and local distribution  are emerging as a powerful design principle for next-generation materials. By tailoring the structure and… Read more: The Power of Tiny Spaces

Sci Adv. 2026 Aug 28;12(35):eaef6109. doi: 10.1126/sciadv.aef6109. Epub 2026 Aug 26. ABSTRACT Achieving a photocatalytic reductive quenching cycle that enables direct oxidation of the photocatalyst radical anion by H(I) species, without requiring stoichiometric oxidants or cocatalysts, remains a long-standing challenge in artificial photoredox catalysis. Here we report a bioinspired approach… Read more: Lignin-degrading-inspired dehydrogenative photocatalysis via reductive quenching of donor-acceptor covalent organic framework

Chemistry. 2026 Aug 25:e71603. doi: 10.1002/chem.71603. Online ahead of print. ABSTRACT Chemotherapy stands out as an effective cancer treatment, although typically accompanied by side effects arising from systemic toxicity of anticancer drugs due to the limited specific targeting of tumor cells. In this study, we present a self-assembled Ru-based polysaccharide… Read more: Targeting Cancer Cells With Self-Assembled Ru-Polysaccharide Photocatalyst for Visible-Light-Induced Activation of Prodrugs

Chem Commun (Camb). 2026 Aug 21. doi: 10.1039/d6cc03614g. Online ahead of print. ABSTRACT Engineering light-responsive nanoparticles (NPs) with tailored nonlinear optical properties is opening new opportunities in precision biophotonics. This article highlights gold nanoparticles (AuNPs) and carbon dots (CDs) as complementary nanoscale platforms for multiphoton bioimaging, photodynamic therapy, sensing, and… Read more: Engineering multiphoton-active gold and carbon nanoparticles for precision biophotonics

J Phys Chem Lett. 2026 Aug 20;17(33):9480-9493. doi: 10.1021/acs.jpclett.6c01805. ABSTRACT Achieving controllable synthesis of metal-organic frameworks (MOFs) with precisely defined crystallinity, phase, orientation, thickness, and hierarchical architecture is essential for tailoring their properties across diverse applications, including gas separation, catalysis, and sensing. Electrochemical synthesis offers unique advantages by enabling room… Read more: Controlled Electrosynthesis of Metal-Organic Frameworks

Angew Chem Int Ed Engl. 2026 Aug 19:e9927134. doi: 10.1002/anie.9927134. Online ahead of print. ABSTRACT The high-entropy halide-perovskite field has expanded rapidly, yet two central chemical questions remain insufficiently understood: how compositional disorder in complex ionic lattices can be converted into predictable, component-differentiated photophysical behavior with tailorable functionality, and what… Read more: High-Entropy Rare-Earth Halide Double Perovskites Convert Compositional Disorder Into Ion-Transport-Stabilized Broadband Near-Infrared Emission for LEDs

J Am Chem Soc. 2026 Aug 12;148(31):33059-33072. doi: 10.1021/jacs.6c04186. ABSTRACT In nature, the enzyme cytochrome-c-nitrite reductase (CcNiR) selectively reduces nitrite to ammonia, involving four nitrite-reduced intermediates, e.g., nitric oxide (NO), nitroxyl species (NO- and its conjugate acid HNO), and hydroxylamine (NH2OH). Similar to enzymatic nitrite reduction, the molecular nickel nitrito… Read more: Bioinspired Nitrite Reduction to Ammonia by Molecular Nickel Polypyridine-Quinoline Complex

Angew Chem Int Ed Engl. 2026 Aug 8:e5095501. doi: 10.1002/anie.5095501. Online ahead of print. ABSTRACT Freshwater scarcity is a global crisis, and sorbent-based atmospheric water harvesting (SAWH) offers location-independent water supply, yet developing fast-kinetic adsorbents remains challenging. In this study, we report an MOF pre-crosslinking strategy using metal-organic frameworks (MOFs)… Read more: Pre-Crosslinking via MOFs With Coordinatively Unsaturated Metal Sites for Fabricating Macroporous Hydrogels Toward Efficient Atmospheric Water Harvesting

Chem Sci. 2026 Aug 5. doi: 10.1039/d6sc01721e. Online ahead of print. ABSTRACT Natural product biosynthetic cytochrome P450s (CYPs) are of increasing interest for their incredible ability to selectively activate inert C-H bonds on highly complex substrates. However, these enzymes are understudied due to difficulties accessing substrates. Here, we use our… Read more: Bioinspired peptide cyclisation enables exploration of cytochrome P450 catalysed sequential oxidation in rufomycin biosynthesis

Discov Nano. 2026 Aug 3;21(1):372. doi: 10.1186/s11671-026-04800-6. ABSTRACT A green synthetic approach was developed for the preparation of a NiCoO₂ nanocomposite using an aqueous extract of Moringa oleifera as both a reducing and stabilizing agent. The synthesized NiCoO₂ nanocomposite exhibited high crystallinity and measurable antimicrobial activity. Detailed characterization using XRD,… Read more: Bioinspired NiCoO(2) nanocomposites derived from Moringa oleifera as a recyclable catalyst for the synthesis of pyrazolopyrano[2,3-d]pyrimidine with potent antimicrobial efficiency

Nat Prod Rep. 2026 Jul 31. doi: 10.1039/d6np00046k. Online ahead of print. ABSTRACT Covering: up to 2025Protoberberine alkaloids (PBs) and tetrahydroprotoberberine alkaloids (THPBs) exhibit diverse pharmacological activities, driving significant interest in their efficient synthesis. This review systematically categorizes recent advances in the total synthesis of these alkaloids based on core-ring-closure… Read more: From botanical origins to modern laboratories: 50 year journey in protoberberine alkaloid total synthesis

Mater Horiz. 2026 Jul 30. doi: 10.1039/d6mh00874g. Online ahead of print. ABSTRACT Stimulus-responsive hydrogels have emerged as versatile platforms for soft robotics and environmental remediation, yet most systems remain limited to either mechanical actuation or catalytic function, with few achieving synergistic coupling where motion actively optimizes chemical performance. Moreover, existing… Read more: A bioinspired mechano-catalytic hydrogel leaf for self-adaptive water purification

Research (Wash D C). 2026 Jul 28;9:1368. doi: 10.34133/research.1368. eCollection 2026. ABSTRACT Nanozymes are emerging as versatile antimicrobial agents to tackle drug-resistant infections and biofilm-associated persistence. In this review, we present an integrated framework that links natural enzyme-mediated host defense to the rational development of antimicrobial nanozymes, and summarize recent… Read more: Antimicrobial Nanozymes: Structure-Activity-Guided Design, Synergy, and Applications

J Oleo Sci. 2026;75(9):1069-1083. doi: 10.5650/jos.ess25285. ABSTRACT The industrial application of phenolic acids (PAs) is significantly limited by their low solubility and poor bioavailability in lipid-rich systems. Lipophilization via esterification of PAs with lipid matrices offers a promising approach to address these challenges. In this study, an efficient lipase-chemical catalytic… Read more: Chemo-enzymatic synthesis, in vitro antioxidant activities and positive effects on oil-in-water emulsion Stabilization of phenolic acid-esterified phosphatidylcholines

Curr Opin Chem Biol. 2026 Sep 2;94:102753. doi: 10.1016/j.cbpa.2026.102753. Online ahead of print. ABSTRACT Proteoglycans (PGs) are intricate macromolecules decorated with linear polysulfated glycosaminoglycans (GAGs) that play critical roles in orchestrating a wide range of physiological and pathological events. Advances in the utilization of recombinant enzymes and biosynthetic pathways have… Read more: Advances in chemoenzymatic synthesis of glycosaminoglycans and proteoglycans

Eur J Med Chem. 2026 Aug 31;319:119275. doi: 10.1016/j.ejmech.2026.119275. Online ahead of print. ABSTRACT Animal-derived low-molecular-weight heparins (LMWHs) are essential anticoagulants but are associated with supply chain vulnerabilities and contamination risks, alongside incomplete protamine reversibility in clinical practice. Herein, we report the precision chemoenzymatic tailoring of bioengineered LMWHs from Escherichia… Read more: Precision chemoenzymatic tailoring of bioengineered low-molecular-weight heparins for protamine-reversible anticoagulation

Methods Mol Biol. 2026;3053:571-580. doi: 10.1007/978-1-0716-5376-0_34. ABSTRACT The assessment of blood group antigens is critical to transfusion medicine practice, as accurately identifying these antigens in both donors and patients is key to ensuring safe transfusions. Although plant lectins have long been used to aid in the identification of many carbohydrate-based… Read more: Defining the Specificity of Blood-Group-Binding Lectins Through Microarray Analysis

J Sci Food Agric. 2026 Aug 20. doi: 10.1002/jsfa.71008. Online ahead of print. ABSTRACT BACKGROUND: Phytosterols, particularly β-sitosterol, exhibit well-recognized cholesterol-lowering activity; however, their practical application is constrained by rigid molecular structures and limited structural tunability. Rational molecular modification combined with the introduction of flexible linkers may provide an effective… Read more: Chemo-enzymatic synthesis of a flexible spacer-modified beta-sitosterol derivative with preserved cholesterol-lowering activity

Org Biomol Chem. 2026 Aug 17. doi: 10.1039/d6ob01079b. Online ahead of print. ABSTRACT Synthetic efforts directed towards the asymmetric total synthesis of two naturally occurring fungal macrolactams, melearorides A and B, were disclosed in this article. The strategy involves a late-stage intramolecular macrolactonisation approach for constructing a 13-membered macrolactam framework.… Read more: Synthetic studies towards naturally occurring macrolactams melearorides A and B: a chemo-enzymatic approach

Carbohydr Res. 2026 Aug 6;569:110060. doi: 10.1016/j.carres.2026.110060. Online ahead of print. ABSTRACT This review characterizes the mechanisms of action of animal polysaccharides (chitin, chitosan, hyaluronan, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin/heparan sulfate) based on their structural and conformational features. A systematic search was conducted in PubMed, Scopus, Web of… Read more: The relationship between the mechanisms of animal polysaccharides and their structural and conformational features

Bioorg Chem. 2026 Aug 10;181:110358. doi: 10.1016/j.bioorg.2026.110358. Online ahead of print. ABSTRACT Heparanase (HPSE) is a promising therapeutic target, yet current heparin-derived inhibitors are limited by structural heterogeneity, poor selectivity, and off-target anticoagulant effects. Here, we synthesized a library of structurally defined heparan sulfate (HS) oligosaccharides via a robust chemoenzymatic… Read more: Chemoenzymatic assembly of structurally defined heparan sulfate oligosaccharides reveals heparanase substrate plasticity and enables inhibitor design

Methods Mol Biol. 2026;3069:89-102. doi: 10.1007/978-1-0716-5508-5_6. ABSTRACT Activity-based ubiquitin probes serve as crucial tools for capturing and elucidating the molecular mechanisms of E3 ligase-catalyzed substrate ubiquitination. We recently reported a chemoenzymatic strategy for generating ubiquitin chain extension probes, which offers advantages such as mild reaction conditions, simple operation, and high… Read more: Design and Semisynthesis of Ubiquitin Extension Probes

Isr J Chem. 2026 Sep;66(5):e70036. doi: 10.1002/ijch.70036. Epub 2026 Aug 5. ABSTRACT In the cell wall of Gram-positive bacteria, wall teichoic acid (WTA) is an abundant and conserved virulence factor. WTAs are especially relevant to methicillin-resistant Staphylococcus aureus. Tremendous synthetic efforts have permitted investigations of the terminal end of this… Read more: Comparing Chemoenzymatic and Conventional Synthetic Strategies to Wall Teichoic Acid Peptidoglycan Fragments