BioCat Collective

ACS Omega. 2026 Aug 27;11(35):52427-52438. doi: 10.1021/acsomega.5c11697. eCollection 2026 Sep 8. ABSTRACT Promiscuous enzymes catalyze multiple biochemical reactions, but predicting their substrate profiles remains challenging because annotations are incomplete, reliable negative labels are scarce, and enzyme-substrate relationships are inherently multilabel. Here, we present PreSEPM (Predictive Substrate Explorer for Promiscuous Enzymes),… Read more: A Novel Unsupervised Learning Model with Bayesian Hyperparameter Optimization for Predicting Substrates of Promiscuous Enzymes

Bioact Mater. 2026 Aug 31;68:42-66. doi: 10.1016/j.bioactmat.2026.08.045. eCollection 2027 Feb. ABSTRACT RNA therapeutics provide a revolutionary means of treating a variety of diseases by precisely regulating gene expression and protein synthesis, with great medical significance. However, there are three key challenges to its clinical application: the inherent instability of RNA,… Read more: From RNA design to delivery: Computational strategies for functional RNA therapeutics

ACS Appl Mater Interfaces. 2026 Sep 14. doi: 10.1021/acsami.6c14068. Online ahead of print. ABSTRACT Controlling the conformation and orientation of enzymes at solid interfaces is a central challenge in the design of functional biohybrid materials, and the outcome depends sensitively on the chemistry and geometry of the enzyme-support interface. Here,… Read more: Engineering the Enzyme-Support Interface: Arginine-Directed Anchoring of Peroxygenase on a β-Ketoester Covalent Organic Framework

Gut. 2026 Sep 11:gutjnl-2026-338471. doi: 10.1136/gutjnl-2026-338471. Online ahead of print. ABSTRACT BACKGROUND: Liver cancer exhibits profound spatial and cellular heterogeneity, contributing to tumour progression, invasion and therapeutic resistance. Emerging evidence suggests that rare low-abundance malignant cell populations residing within discrete tissue niches influence these processes. However, their reliable detection and… Read more: NCACC maps cross-sample spatial niches and reveals cIgG+ epithelial rare cells driving liver cancer invasion

Adv Sci (Weinh). 2026 Sep 11:e77474. doi: 10.1002/advs.77474. Online ahead of print. ABSTRACT The utility of enzymes in organic synthesis is constrained by the limited ability to predict the scope of small-molecule substrates that a given enzyme can act upon. The problem has proven challenging to both classical computational-chemistry approaches… Read more: Robots and Minimal, Physics-Informed Features: A Hybrid Framework for Enzyme Catalysis

Sci Adv. 2026 Sep 11;12(37):eaeg3595. doi: 10.1126/sciadv.aeg3595. Epub 2026 Sep 11. ABSTRACT Simulating chemical reactivity remains a central challenge in molecular dynamics, historically constrained by the trade-off between ab initio accuracy and classical efficiency. We present QuantaMind, a machine learning force field (MLFF) framework that attains density functional theory (DFT)-level… Read more: Bridging the accuracy-speed divide in reactive molecular dynamics with QuantaMind MD

Biotechnol J. 2026 Sep;21(9):e70306. doi: 10.1002/biot.70306. ABSTRACT The biocatalytic synthesis of UDP-glucuronic acid (UDPGA), a key precursor for glucuronides and high-value carbohydrates, is limited by an unstable UDP-glucose (UDPG) supply in coupled systems. In this study, through an extensive screening of 10 sucrose synthases derived from both eukaryotic and prokaryotic… Read more: Engineering the Stability of Sucrose Synthase to Enable Efficient Coupled Production of UDP-Glucuronic Acid

Small. 2026 Sep 10:e75706. doi: 10.1002/smll.75706. Online ahead of print. ABSTRACT The formation of multidrug-resistant barriers dominated by biofilms is a intelligent living of methicillin-resistant Staphylococcus aureus (MRSA), resulting in refractory infections. Reactive oxygen species (ROS)-related biocatalysis triggered by nanomaterials have demonstrated outstanding resistance-free advantages, while the therapeutic effectiveness is… Read more: Cu/Cu2O Heterostructure Nanoplatform Driven Photo-Thermoelectric Catalysis Targets LuxS and Agr Dual Quorum Sensing Systems of Methicillin-Resistant Staphylococcus aureus

Spectrochim Acta A Mol Biomol Spectrosc. 2026 Aug 18;365:128620. doi: 10.1016/j.saa.2026.128620. Online ahead of print. ABSTRACT Real-time monitoring of the in situ release kinetics of nano-drug delivery systems (DDS) is crucial for enhancing the precision of cancer chemotherapy and reducing systemic toxicity. In this study, an integrated surface-enhanced Raman scattering… Read more: Integrated three-dimensional TiO2 nanotube Array/silver platform for SERS-traceable chemotherapy and real-time in situ monitoring of pH-responsive drug release

Adv Biochem Eng Biotechnol. 2026 Sep 11. doi: 10.1007/10_2026_355. Online ahead of print. ABSTRACT Plant triterpenoids, including tetracyclic and pentacyclic triterpene saponins, represent a large and structurally diverse class of natural products with broad pharmacological activities such as anti-inflammatory, antitumor, hepatoprotective, and immunomodulatory effects. These compounds are widely used in… Read more: Biosynthesis and Biotransformation of Plant Triterpenoids: Current Advances and Future Perspectives

Bioresour Bioprocess. 2026 Sep 10;13(1):131. doi: 10.1186/s40643-026-01130-4. ABSTRACT Efficient use of reducing equivalents is critical for productive turnover in cytochrome P450 redox enzymes, yet improving activity without compromising substrate affinity remains challenging. Here, we engineered the second-sphere region of PbdA, a cytochrome P450 from Rhodococcus jostii RHA1 that catalyzes veratrate… Read more: A second-sphere variant of cytochrome P450 PbdA improves turnover and apparent coupling in veratrate oxidation

Bioresour Bioprocess. 2026 Sep 10;13(1):131. doi: 10.1186/s40643-026-01130-4. ABSTRACT Efficient use of reducing equivalents is critical for productive turnover in cytochrome P450 redox enzymes, yet improving activity without compromising substrate affinity remains challenging. Here, we engineered the second-sphere region of PbdA, a cytochrome P450 from Rhodococcus jostii RHA1 that catalyzes veratrate… Read more: A second-sphere variant of cytochrome P450 PbdA improves turnover and apparent coupling in veratrate oxidation

Adv Biochem Eng Biotechnol. 2026 Sep 11. doi: 10.1007/10_2026_355. Online ahead of print. ABSTRACT Plant triterpenoids, including tetracyclic and pentacyclic triterpene saponins, represent a large and structurally diverse class of natural products with broad pharmacological activities such as anti-inflammatory, antitumor, hepatoprotective, and immunomodulatory effects. These compounds are widely used in… Read more: Biosynthesis and Biotransformation of Plant Triterpenoids: Current Advances and Future Perspectives

J Phys Chem B. 2026 Sep 10;130(36):9045-9057. doi: 10.1021/acs.jpcb.6c01533. ABSTRACT Fumarate-adding enzymes (FAE) are a subset of the glycyl radical enzyme superfamily involved in anaerobic hydrocarbon degradation. Benzylsuccinate synthase (BSS) catalyzes the enantiospecific formation of (R)-benzylsuccinate from toluene and fumarate, initiating anaerobic toluene degradation. In this paper, we present the… Read more: The Origin of the Kinetic Isotope Effect and Mechanism of H/D Exchange in Radical C-C Bond Formation Catalyzed by Benzylsuccinate Synthase: Experiments and Microkinetic Modeling

FEMS Microbes. 2026 Aug 22;7:xtag045. doi: 10.1093/femsmc/xtag045. eCollection 2026. ABSTRACT The Altiplano-Puna plateau lies at ∼4000 m above sea level in the volcanic Andes cordillera. Together with the adjacent Atacama Desert, it forms one of the most hyperarid regions on the planet. Wetlands are rare, influenced by hydrothermalism and, due… Read more: Vulnerable microbial communities in Atacama-Altiplano wetlands: modern analogs of ancient ecosystems with implications for sustainability and conservation

ACS Nano. 2026 Sep 1;20(34):23893-23906. doi: 10.1021/acsnano.6c07948. ABSTRACT Direct solar-to-chemical conversion offers a compelling route to clean, dispatchable energy. Photosystem I (PSI), an evolutionarily optimized light-driven oxidoreductase, can be repurposed for solar-fuel production by coupling its photochemistry to catalytic interfaces. However, the molecular determinants that govern productive electron transfer to… Read more: Molecular Design Principles for Photosystem I-Based Biohybrid Solar Fuel Catalysts

Nat Commun. 2026 Aug 5;17(1):9427. doi: 10.1038/s41467-026-76316-7. ABSTRACT Light-dependent protochlorophyllide oxidoreductase (LPOR) is a light-driven enzyme in flowering plants. It is involved in chlorophyll biosynthesis while also reorganizing membrane lipids into the cubic membrane network that supports chloroplast development. However, the structural basis of these two activities and their relationship… Read more: Structures of LPOR-Chlide complexes reveal the structural basis of membrane remodeling and photocatalysis

Small. 2026 Sep 2:e75590. doi: 10.1002/smll.75590. Online ahead of print. ABSTRACT Oscillatory fluid flows underpin transport, mixing, and signal propagation in living systems, yet artificial microfluidic platforms rely almost extensively on external power or chemically driven gradients to reproduce such dynamics. Here, we introduce a fuel-free strategy based on photo-mechanical… Read more: Photoactuated Micropumps Enable Oscillatory Fluidics and Autonomous Locomotion

Methods Mol Biol. 2026;3032:47-67. doi: 10.1007/978-1-0716-5257-2_4. ABSTRACT Photobiocatalysis, an interdisciplinary frontier integrating chemistry, biology, and catalysis, drives enzymatic catalysis from natural reactions to new-to-nature transformations via protein engineering and photochemistry. This review centers on enzyme classes, covering nine key families: fatty acid photodecarboxylases (FAPs), nicotinamide-dependent reductases, flavin-dependent “ene”-reductases (EREDs), and… Read more: Designing and Engineering Enzymes for New-to-Nature Photobiocatalysis

Methods Mol Biol. 2026;3032:47-67. doi: 10.1007/978-1-0716-5257-2_4. ABSTRACT Photobiocatalysis, an interdisciplinary frontier integrating chemistry, biology, and catalysis, drives enzymatic catalysis from natural reactions to new-to-nature transformations via protein engineering and photochemistry. This review centers on enzyme classes, covering nine key families: fatty acid photodecarboxylases (FAPs), nicotinamide-dependent reductases, flavin-dependent “ene”-reductases (EREDs), and… Read more: Designing and Engineering Enzymes for New-to-Nature Photobiocatalysis

Angew Chem Int Ed Engl. 2026 Aug 28:e5856873. doi: 10.1002/anie.5856873. Online ahead of print. ABSTRACT Light-driven photoredox catalysis can shift intracellular NADH/NAD+ balance by oxidizing NADH, but intracellular NADH pools are dynamically replenished through enzyme-coupled redox metabolism. We show that ALDH-mediated restoration of NADH/NAD+ balance can buffer photoredox-induced NADH depletion,… Read more: ALDH Inhibition-Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Nature. 2026 Jul 27. doi: 10.1038/s41586-026-10930-9. Online ahead of print. ABSTRACT Non-native photoenzymes have enabled myriad asymmetric bond-forming events that are otherwise challenging or at present impossible with small-molecule catalysis1,2. These reactions require enzymes with cofactors that are strong absorbers in the visible region with reasonably long-lived excited states, such… Read more: Pyridoxal photoenzymes for asymmetric radical-radical cross-couplings

Molecules. 2026 Aug 13;31(16):2830. doi: 10.3390/molecules31162830. ABSTRACT A light-promoted C-H/C-H coupling of imidazo[1,2-a]pyridines with 5-(hetero)aryl-1,2,5-oxadiazolo[3,4-b]pyrazines was developed using a heterogeneous oxidative photocatalytic system based on molecular oxygen, nanosized TiO2, and light irradiation. The method provides direct access to C3-heteroarylated imidazo[1,2-a]pyridines under metal-free conditions and expands the synthetic utility of electron-deficient… Read more: Light-Promoted C-H/C-H Coupling of Imidazo[1,2-<em>a</em>]pyridines with 5-(Hetero)aryl-1,2,5-oxadiazolo[3,4-<em>b</em>]pyrazines over TiO2 and Experimental/In Silico Evaluation of COX-1 and COX-2 Inhibitory Activity

Angew Chem Int Ed Engl. 2026 Aug 25:e8631704. doi: 10.1002/anie.8631704. Online ahead of print. ABSTRACT Photocatalytic NADH regeneration is limited by poor recovery of the rhodium mediator (Rh*) and enzyme deactivation caused by free Rh* species and photogenerated holes. In this study, we introduce poly(acrylic acid) brushes grafted onto conjugated… Read more: Conjugated Microporous Polymers Bearing Poly(Acrylic Acid) Brushes: Site-Specific Rhodium Immobilization for Efficient and Enzyme-Compatible Photocatalytic NADH Regeneration

Angew Chem Int Ed Engl. 2026 Aug 19:e5014162. doi: 10.1002/anie.5014162. Online ahead of print. ABSTRACT Biotin-streptavidin artificial metalloenzymes (ArMs) provide a platform to integrate transition-metal catalysis within a protein-defined microenvironment. Traditional indolone syntheses often rely on transition metal catalysts, high temperatures, and strong oxidants, limiting functional-group tolerance, and sustainability. In… Read more: Iridium Artificial Metalloenzymes Enabled Photo-Enzymatic Radical Indolone Synthesis

Molecules. 2026 Jul 28;31(15):2626. doi: 10.3390/molecules31152626. ABSTRACT The chronic overuse of antibiotics has accelerated the emergence of antibiotic-resistant bacteria, creating a global public health crisis as conventional therapies fail against multidrug-resistant pathogens spreading through water and food chains. Cadmium sulfide (CdS) has been established as an important visible-light-driven photocatalyst for… Read more: CdS-Based Photocatalysts for Antimicrobial Applications: From Quantum Dots to Z-Scheme Heterojunctions-Mechanisms, Challenges, and Future Perspectives

J Am Chem Soc. 2026 Aug 12;148(31):33757-33766. doi: 10.1021/jacs.6c11128. ABSTRACT We report a tetrazine-regulated in situ hydrazine release strategy to synthesize highly crystalline azine-linked COFs (AZ-COFs) with varied central cores (triazine, cyanuric acid, benzene). The slow hydrolysis of 3,6-dimethyl-1,2,4,5-tetrazine enables controlled hydrazine generation, allowing kinetically moderated azine formation and overcoming… Read more: Tetrazine-Regulated Synthesis of Azine-Linked Covalent Organic Frameworks for Photocatalytic Cofactor Regeneration and Photoenzymatic Catalysis

J Hazard Mater. 2026 Aug 10;515:143227. doi: 10.1016/j.jhazmat.2026.143227. Online ahead of print. ABSTRACT To address the challenge of simultaneously achieving efficient removal, enhanced mineralization, and risk mitigation of dimethyl phthalate (DMP), a multifunctional sodium alginate (SA) microbead platform integrating photocatalysis, enzymatic catalysis, and magnetic recovery was developed. A CeO2@Bi2WO6 heterojunction… Read more: Interfacial photo-enzyme coupled on sodium alginate microbeads co-immobilizing lipase and CeO(2)@Bi(2)WO(6) heterojunction for stepwise degradation of dimethyl phthalate

Luminescence. 2026 Aug;41(8):e70600. doi: 10.1002/bio.70600. ABSTRACT Zinc oxide nanoparticles (ZnO NPs) were successfully synthesized via an eco-friendly green route using aqueous leaf extract of Sonchus wightianus as a natural reducing and capping agent. UV-Vis spectroscopy revealed a characteristic absorption peak at 267 nm, with a direct optical band gap of… Read more: Plant-Mediated Synthesis of ZnO Nanoparticles From Sonchus wightianus: Physicochemical Characterization and Evaluation of Photocatalytic, Antibiofilm, and Antioxidant Potential

Angew Chem Int Ed Engl. 2026 Aug 5:e5802081. doi: 10.1002/anie.5802081. Online ahead of print. ABSTRACT Photocatalytic hydrogen peroxide (H2O2) synthesis via oxygen reduction reaction (ORR) offers a sustainable alternative to energy-intensive anthraquinone processes. However, its efficiency is hindered by poor selectivity and instability stemming from reactive superoxide intermediates through the… Read more: Induced-Fit for Oxygen Adsorption: Flexible Conjugated Microporous Polymers With Self-Adaptive Active Sites for H2O2 Photosynthesis

J Agric Food Chem. 2026 Sep 9;74(35):27346-27370. doi: 10.1021/acs.jafc.6c08020. ABSTRACT α-L-Rhamnosidase is a glycoside hydrolase (GH) that cleaves α-L-rhamnosidic bonds in diverse natural substrates, including oligosaccharides, glycoproteins, flavonoids, and glycolipids that contain terminal L-rhamnose. Owing to its broad substrate specificity, it has attracted growing interest in biotechnology, food processing, pharmaceuticals,… Read more: Structural and Functional Perspectives of alpha-L-Rhamnosidase in Glycoside Biotransformation, Therapeutic Applications, and Enzyme Engineering

Harmful Algae. 2026 Nov;159:103210. doi: 10.1016/j.hal.2026.103210. Epub 2026 Aug 29. ABSTRACT As a dormant stage of the dinoflagellate life cycle, resting cysts play crucial ecological roles, particularly for bloom-forming species, as supported by abundant evidence. They can remain viable in marine sediments for decades to centuries and directly regulate seasonal… Read more: Multi-level evidence reveals a possibly vital role of H+-pyrophosphatase in the energetic metabolism of dinoflagellate resting cysts

Nat Commun. 2026 Jul 25;17(1):9044. doi: 10.1038/s41467-026-75811-1. ABSTRACT Herbicides in combination with genetically modified herbicide-resistant crops have revolutionized modern weed management, increased crop yields, and facilitated farming practices. However, rapid evolution of herbicide-resistant weeds necessitates new resistance traits to sustain control efficacy. Here, we introduce a terminal carboxyl anchoring mechanism-inspired… Read more: Anchoring mechanism-inspired discovery of a bacterial P450 gene conferring resistance to auxin herbicides

J Struct Biol X. 2026 Jul 31;14:100156. doi: 10.1016/j.yjsbx.2026.100156. eCollection 2026 Dec. ABSTRACT Allosteric regulation in biosynthetic L-threonine deaminase (BTD) has long been attributed to effector-induced conformational changes. Here, we identify a trans-interface coupling mechanism that regulates the active site architecture of EcIlvA, the BTD homolog of Escherichia coli. Starting… Read more: Trans-interface coupling in the tetrameric enzyme underlies allosteric control in Escherichia coli biosynthetic threonine deaminase

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

ACS Appl Mater Interfaces. 2026 Sep 14. doi: 10.1021/acsami.6c12503. Online ahead of print. ABSTRACT A cytochrome P450-mimetic monodispersed Fe-porphyrin-based porous framework is designed and synthesized via a FeCl3-assisted Friedel-Crafts reaction, to combine the advantages of heterogeneous systems with enzymatic reactivity. Specifically, the Fe-porphyrin site in this material mimics the heme-center… Read more: Bioinspired Fe-Porphyrin Sites in a Porous Organic Polymer for Aerobic Oxidative Cyclization of Bioactive 2-Aminobenzoxazole

ACS Appl Mater Interfaces. 2026 Sep 14. doi: 10.1021/acsami.6c12503. Online ahead of print. ABSTRACT A cytochrome P450-mimetic monodispersed Fe-porphyrin-based porous framework is designed and synthesized via a FeCl3-assisted Friedel-Crafts reaction, to combine the advantages of heterogeneous systems with enzymatic reactivity. Specifically, the Fe-porphyrin site in this material mimics the heme-center… Read more: Bioinspired Fe-Porphyrin Sites in a Porous Organic Polymer for Aerobic Oxidative Cyclization of Bioactive 2-Aminobenzoxazole

ACS Appl Mater Interfaces. 2026 Sep 14. doi: 10.1021/acsami.6c12503. Online ahead of print. ABSTRACT A cytochrome P450-mimetic monodispersed Fe-porphyrin-based porous framework is designed and synthesized via a FeCl3-assisted Friedel-Crafts reaction, to combine the advantages of heterogeneous systems with enzymatic reactivity. Specifically, the Fe-porphyrin site in this material mimics the heme-center… Read more: Bioinspired Fe-Porphyrin Sites in a Porous Organic Polymer for Aerobic Oxidative Cyclization of Bioactive 2-Aminobenzoxazole

ACS Appl Mater Interfaces. 2026 Sep 14. doi: 10.1021/acsami.6c12503. Online ahead of print. ABSTRACT A cytochrome P450-mimetic monodispersed Fe-porphyrin-based porous framework is designed and synthesized via a FeCl3-assisted Friedel-Crafts reaction, to combine the advantages of heterogeneous systems with enzymatic reactivity. Specifically, the Fe-porphyrin site in this material mimics the heme-center… Read more: Bioinspired Fe-Porphyrin Sites in a Porous Organic Polymer for Aerobic Oxidative Cyclization of Bioactive 2-Aminobenzoxazole

ACS Appl Mater Interfaces. 2026 Sep 14. doi: 10.1021/acsami.6c12503. Online ahead of print. ABSTRACT A cytochrome P450-mimetic monodispersed Fe-porphyrin-based porous framework is designed and synthesized via a FeCl3-assisted Friedel-Crafts reaction, to combine the advantages of heterogeneous systems with enzymatic reactivity. Specifically, the Fe-porphyrin site in this material mimics the heme-center… Read more: Bioinspired Fe-Porphyrin Sites in a Porous Organic Polymer for Aerobic Oxidative Cyclization of Bioactive 2-Aminobenzoxazole

ACS Appl Mater Interfaces. 2026 Sep 14. doi: 10.1021/acsami.6c12503. Online ahead of print. ABSTRACT A cytochrome P450-mimetic monodispersed Fe-porphyrin-based porous framework is designed and synthesized via a FeCl3-assisted Friedel-Crafts reaction, to combine the advantages of heterogeneous systems with enzymatic reactivity. Specifically, the Fe-porphyrin site in this material mimics the heme-center… Read more: Bioinspired Fe-Porphyrin Sites in a Porous Organic Polymer for Aerobic Oxidative Cyclization of Bioactive 2-Aminobenzoxazole

ACS Appl Mater Interfaces. 2026 Sep 14. doi: 10.1021/acsami.6c12503. Online ahead of print. ABSTRACT A cytochrome P450-mimetic monodispersed Fe-porphyrin-based porous framework is designed and synthesized via a FeCl3-assisted Friedel-Crafts reaction, to combine the advantages of heterogeneous systems with enzymatic reactivity. Specifically, the Fe-porphyrin site in this material mimics the heme-center… Read more: Bioinspired Fe-Porphyrin Sites in a Porous Organic Polymer for Aerobic Oxidative Cyclization of Bioactive 2-Aminobenzoxazole

J Am Chem Soc. 2026 Sep 9;148(35):38519-38529. doi: 10.1021/jacs.6c15193. ABSTRACT As Brønsted acid sites (BASs) serve as the active centers in zeolite-catalyzed reactions, comprehending their precise location, population, and dynamic behavior is crucial for catalyst optimization─yet their characterization remains a significant challenge. Here, we demonstrate that 29Si NMR exhibits high… Read more: NMR-Solved Proton Fine Locations Reveal the Dynamic Flexibility of Brønsted Acid Sites in the SAPO-34 Molecular Sieve

Angew Chem Int Ed Engl. 2026 Sep 8:e2349367. doi: 10.1002/anie.2349367. Online ahead of print. ABSTRACT Enantioselective C(sp3)─H functionalization reactions are appealing synthetic organic chemistry tools to streamline access to valuable chiral molecules from simple precursors. Chiral piperidines are ubiquitous motifs in pharmaceuticals and natural products, yet methods for their preparation… Read more: Direct Access to Chiral Piperidines by Enantioselective HAT-Initiated C(sp3)─H Oxidation

Angew Chem Int Ed Engl. 2026 Sep 7:e9907362. doi: 10.1002/anie.9907362. Online ahead of print. ABSTRACT Polyolefin hydrogenolysis offers a promising route for the upcycling of plastic waste, yet is hindered by the high cost of noble-metal catalysts and the safety concerns of high-pressure H2. Current systems typically rely on Ru… Read more: Ambient-Pressure Polyolefin Upcycling With Earth-Abundant Catalyst

Angew Chem Int Ed Engl. 2026 Sep 4:e6571996. doi: 10.1002/anie.6571996. Online ahead of print. ABSTRACT Precious metal nanoparticles generally aggregate through Ostwald ripening in the absence of anchoring sites, whereas in the presence of suitable coordination environments, they can disperse into thermodynamically stable single-atom (SA) with chelate structures. Herein, an… Read more: Effects of Phase-Transition-Enabled Atomic Shuttling Between Nanoparticles and Single-Atom Sites for Boosted Formic Acid Electro-Oxidation

Carbohydr Polym. 2026 Oct 15;390:125786. doi: 10.1016/j.carbpol.2026.125786. Epub 2026 Aug 24. ABSTRACT Polysaccharide-based physical hydrogels are promising drug-delivery platforms due to their biocompatibility, tunable mechanical properties, and reversible crosslinking. However, bulk hydrogels may require in situ gelation for administration, while controlled release of nanoparticles larger than the hydrogel mesh remains… Read more: An injectable kappa-carrageenan/konjac-glucomannan microgel platform for localized and controlled release of doxorubicin-loaded biomimetic nanoparticles

Carbohydr Polym. 2026 Oct 15;390:125727. doi: 10.1016/j.carbpol.2026.125727. Epub 2026 Aug 4. ABSTRACT Engineering cyclodextrin-based materials enabling real-time diagnosis and on-demand therapy is highly desirable for hyperuricemia and gout management. Here, we design a novel cyclodextrin-engineered bioinspired nanozyme (T-CD/Pt), and integrate it into a bi-regional microneedle (TP-MNs). Coupled with a biowaste-derived… Read more: Cyclodextrin-engineered bioinspired nanozyme microneedle for adaptive theranostic regulation of hyperuricemia and gout

Small. 2026 Sep 3:e75628. doi: 10.1002/smll.75628. Online ahead of print. ABSTRACT Inspired by the electron-transfer function of biological ferredoxins, we report a biomimetic iron-sulfur cluster-functionalized porous organic polymer (FeS-POP) for efficient oxygen evolution reaction (OER). FeS-POP is constructed through polymerization-induced restructuring of a diamagnetic diiron carbonyl precursor (FeS-Com), wherein Fe─Fe… Read more: Restructuring of a Diamagnetic Diiron-Sulfur Complex to Paramagnetic Ferredoxin-Inspired [Fe(4)S(4)] Porous Organic Polymer Stimulates Optimally Coordinated Sites for Oxygen Evolution Catalysis

Adv Mater. 2026 Aug 27:e74827. doi: 10.1002/adma.74827. Online ahead of print. ABSTRACT Flavin-dependent monooxygenases (FMOs) catalyze redox reactions central to antibiotic degradation and metabolic detoxification, yet replicating their intricate cofactor-dependent electron transfer in synthetic systems has remained elusive. Here, we report an electronic modulation strategy that enables cofactor-free FMO-like catalysis… Read more: Entropy-Encoded Electronic Reconstruction in High-Entropy Nanozymes Enables Cofactor-Free Monooxygenase-Like Catalysis

Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly… Read more: A Green Chemoenzymatic Route to 28-epi-Homobrassinolide Enabled by OsO(4)-Free Strategy and Engineered Baeyer-Villiger Monooxygenase With MOF Immobilization

Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly… Read more: A Green Chemoenzymatic Route to 28-epi-Homobrassinolide Enabled by OsO(4)-Free Strategy and Engineered Baeyer-Villiger Monooxygenase With MOF Immobilization

Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly… Read more: A Green Chemoenzymatic Route to 28-epi-Homobrassinolide Enabled by OsO(4)-Free Strategy and Engineered Baeyer-Villiger Monooxygenase With MOF Immobilization

Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly… Read more: A Green Chemoenzymatic Route to 28-epi-Homobrassinolide Enabled by OsO4-Free Strategy and Engineered Baeyer-Villiger Monooxygenase With MOF Immobilization

Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly… Read more: A Green Chemoenzymatic Route to 28-epi-Homobrassinolide Enabled by OsO(4)-Free Strategy and Engineered Baeyer-Villiger Monooxygenase With MOF Immobilization

ChemMedChem. 2026 Sep 14;21(17):e70487. doi: 10.1002/cmdc.70487. ABSTRACT The glycopeptide antibiotics (GPAs) remain clinical antibiotics used against drug-resistant Gram-positive infections. The discovery of GPAs continues, with new type IIa and V GPAs, the kineomicins, the rimomycins, and corbomycin, being recently identified. Despite this larger repertoire of GPA scaffolds and crosslinking types,… Read more: Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr-Pyrazole Chemistry

J Oleo Sci. 2026;75(9):1069-1083. doi: 10.5650/jos.ess25285. ABSTRACT The industrial application of phenolic acids (PAs) is significantly limited by their low solubility and poor bioavailability in lipid-rich systems. Lipophilization via esterification of PAs with lipid matrices offers a promising approach to address these challenges. In this study, an efficient lipase-chemical catalytic… Read more: Chemo-enzymatic synthesis, in vitro antioxidant activities and positive effects on oil-in-water emulsion Stabilization of phenolic acid-esterified phosphatidylcholines

Curr Opin Chem Biol. 2026 Sep 2;94:102753. doi: 10.1016/j.cbpa.2026.102753. Online ahead of print. ABSTRACT Proteoglycans (PGs) are intricate macromolecules decorated with linear polysulfated glycosaminoglycans (GAGs) that play critical roles in orchestrating a wide range of physiological and pathological events. Advances in the utilization of recombinant enzymes and biosynthetic pathways have… Read more: Advances in chemoenzymatic synthesis of glycosaminoglycans and proteoglycans

Eur J Med Chem. 2026 Aug 31;319:119275. doi: 10.1016/j.ejmech.2026.119275. Online ahead of print. ABSTRACT Animal-derived low-molecular-weight heparins (LMWHs) are essential anticoagulants but are associated with supply chain vulnerabilities and contamination risks, alongside incomplete protamine reversibility in clinical practice. Herein, we report the precision chemoenzymatic tailoring of bioengineered LMWHs from Escherichia… Read more: Precision chemoenzymatic tailoring of bioengineered low-molecular-weight heparins for protamine-reversible anticoagulation

Methods Mol Biol. 2026;3053:571-580. doi: 10.1007/978-1-0716-5376-0_34. ABSTRACT The assessment of blood group antigens is critical to transfusion medicine practice, as accurately identifying these antigens in both donors and patients is key to ensuring safe transfusions. Although plant lectins have long been used to aid in the identification of many carbohydrate-based… Read more: Defining the Specificity of Blood-Group-Binding Lectins Through Microarray Analysis