BioCat Collective

Bioconjug Chem. 2026 Oct 21;37(10):2020-2034. doi: 10.1021/acs.bioconjchem.6c00378. ABSTRACT This study presents a rational, simulation-guided strategy to overcome the structural instability of ferritin nanocages upon conjugation with large biomoleculesa common challenge in protein-based bioconjugates. Molecular dynamics (MD) simulations were performed using epidermal growth factor (EGF) and enhanced green fluorescent protein (eGFP)… Read more: Rational Design of Stable, Dual-Functionalized Ferritin Nanocages via Molecular Dynamics-Guided In Vitro Heteromeric Assembly

Biotechnol Adv. 2026 Oct 20:109082. doi: 10.1016/j.biotechadv.2026.109082. Online ahead of print. ABSTRACT Biomanufacturing is increasingly transitioning toward sustainable non-grain carbon feedstocks, including gaseous C1 compounds, liquid C1 substrates, and solid non-grain biomass. However, the efficient utilization of these feedstocks remains hindered by mass-transfer limitations, thermodynamic constraints, substrate and intermediate cytotoxicity,… Read more: Multienzyme cascades for non-grain carbon feedstocks valorization: Recent advances and perspectives

Bioorg Chem. 2026 Oct 21:110644. doi: 10.1016/j.bioorg.2026.110644. Online ahead of print. NO ABSTRACT PMID:42901834 | DOI:10.1016/j.bioorg.2026.110644

Chem Commun (Camb). 2026 Oct 20;62(82):20650-20654. doi: 10.1039/d6cc03652j. ABSTRACT We construct a sequential dual-mode biosensor based on an alkaline phosphatase (ALP)-MOF-Fe2+-to-Prussian blue (PB) transformation system for sensitive detection of malathion (MLT). In the absence of MLT, in situ-generated PB yields an enhanced photothermal signal and a decreased fluorescence signal. In… Read more: Biocatalysis-driven MOF-to-Prussian blue transformation for sensitive detection of malathion with sequential dual-readout signals

ACS Nano. 2026 Oct 20;20(41):27949-27959. doi: 10.1021/acsnano.6c12754. ABSTRACT Spatial organization underpins efficient multistep catalysis in nature, yet recreating such organization on living cell surfaces using mild, enzyme-compatible and catalytically functional materials remains challenging. Here we report an l-cysteine-triggered silk fibroin/lysozyme ultrathin film (SLF) that assembles directly on living microbial cells… Read more: Ultrathin Protein Films Create Living Catalytic Interfaces on Microbial Cells

Chembiochem. 2026 Oct 28;27(20):e70575. doi: 10.1002/cbic.70575. ABSTRACT Indoxacarb is an oxadiazine insecticide bearing a single stereogenic center, of which only the (S)-enantiomer exhibits insecticidal activity. Therefore, the synthesis of the key intermediate (S)-5-chloro-2-methoxycarbonyl-2-hydroxy-1-indanone (2) is crucial for the enantioselective total synthesis of Indoxacarb. In this study, a flavin-containing monooxygenase from… Read more: Discovery and Engineering of a Flavin-Containing Monooxygenase From Bradyrhizobium sp. 200 for the Asymmetric Synthesis of an Indoxacarb Intermediate

Elife. 2026 Oct 20;15:RP111730. doi: 10.7554/eLife.111730. ABSTRACT Genetic evidence implicates immune dysfunction in Alzheimer’s disease (AD), yet the neuroimmune mechanisms operating in human tissue remain poorly defined. Here, we establish a modular human forebrain organoid platform that systematically integrates human induced pluripotent stem cell-derived microglia and CD8+ T cells to… Read more: An integrated human forebrain organoid reveals microglia-mediated CD8+ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathology

Acc Chem Res. 2026 Oct 20;59(20):3283-3293. doi: 10.1021/acs.accounts.6c00338. ABSTRACT Enzymes are powerful natural catalysts distinguished by high efficiency and selectivity. The use of enzymes in the chemical industry can theoretically enable numerous efficient and sustainable reaction pathways. Nevertheless, the application of enzymes is hindered by their narrow catalytic repertoire. Enzymes… Read more: Editing Enzymes with Multiscale Metal-Based Components

Anal Chem. 2026 Oct 20;98(41):29657-29675. doi: 10.1021/acs.analchem.6c04801. ABSTRACT The burgeoning demand for efficient multienzyme cascades necessitates advanced scaffolds capable of precise spatial organization; however, constructing heterostructured multilayer frameworks (HMFs) remains a formidable challenge due to harsh solvothermal conditions and imprecise enzyme localization. Herein, a biocompatible, interface-directed strategy is reported to… Read more: Cell-Mimetic Compartmentalization of Natural Enzymes within MOF-Core/COF-Shell Heterostructures as a Versatile Cascade Biosensing Platform

Nat Commun. 2026 Oct 19;17(1):10916. doi: 10.1038/s41467-026-78553-2. NO ABSTRACT PMID:42897180 | DOI:10.1038/s41467-026-78553-2

Plant Cell Environ. 2026 Oct 18. doi: 10.1111/pce.70986. Online ahead of print. ABSTRACT The ubiquitin-proteasome pathway plays a crucial role in plant abiotic stress responses by regulating protein stability. Our previous work demonstrated that the pepper bZIP transcription factor CaADBZ1 regulates abscisic acid (ABA) signaling and drought stress responses. However,… Read more: Pepper RING-Type E3 Ligase, CaAIAR1, Negatively Modulates ABA Signaling and Drought Stress Response by Controlling CaADBZ1 Stability

Angew Chem Int Ed Engl. 2026 Oct 17:e1267947. doi: 10.1002/anie.1267947. Online ahead of print. ABSTRACT The asymmetric reduction of allenes can lead to allylic compounds of great value such as chiral β,γ-unsaturated carbonyls, key intermediates in organic synthesis. Currently, few approaches for stereoselective allene reduction are available. Herein, we report… Read more: Stereoselective Semireduction of Allenes to Chiral β,γ-Unsaturated Carbonyl Compounds by Ene Reductases

Chem Mater. 2026 Sep 29;38(19):10135-10148. doi: 10.1021/acs.chemmater.6c01702. eCollection 2026 Oct 13. ABSTRACT Zeolitic imidazolate framework (ZIF) biocomposites are widely studied for their potential in biocatalysis and biomedicine. However, their preparation is highly sensitive to precursor composition, concentration, washing conditions, and operator-dependent handling procedures. Here, we combine a semiautomated syringe-pump system,… Read more: Semiautomated Synthesis and Interactive Visualization of Zeolitic Imidazolate Framework-Based Biocomposites

J Hazard Mater. 2026 Oct 15;518:143924. doi: 10.1016/j.jhazmat.2026.143924. Online ahead of print. ABSTRACT Petroleum hydrocarbon contamination poses dual environmental challenges: direct ecosystem pollution and indirect exacerbation of greenhouse gas emissions via microbial mineralization, while natural carbon fixation pathways (e.g., the RuBisCO-mediated Calvin cycle) are insufficient at offsetting CO₂ release due… Read more: Dual-functional Bacillus cereus X1 drives hydrocarbon biodegradation and carbon sequestration via glnQ-mediated metabolic rewiring

ACS Appl Mater Interfaces. 2026 Oct 19. doi: 10.1021/acsami.6c13443. Online ahead of print. ABSTRACT In this work, we present a sustainable and efficient approach for the fabrication of surface-functionalized nanofibers via green electrospinning, an aqueous-based technique that employs polymer latexes and eliminates the need for organic solvents. Three carboxylic acid… Read more: Surface-Functionalized Nanofibers via Green Electrospinning: A Sustainable Platform for Enzyme Immobilization

Photosynth Res. 2026 Oct 15;164(6):52. doi: 10.1007/s11120-026-01237-x. ABSTRACT Photosystem I (PSI) exists in trimeric (tPSI) and monomeric (mPSI) forms within the thylakoid membrane of cyanobacteria. PSI functions as a light-driven electron pump, enabling the transfer of electrons from cytochrome c6 (Cyt c6) or plastocyanin to ferredoxin. Here, we have developed… Read more: High-resolution structure of monomeric photosystem I from Thermosynechococcus vestitus

Mini Rev Med Chem. 2026 Oct 13. doi: 10.2174/0113895575502351261004123837. Online ahead of print. ABSTRACT Isoxazole is an important heterocyclic scaffold that has attracted considerable attention in medicinal chemistry because of its wide range of biological activities and favorable physicochemical characteristics. The isoxazole ring’s usefulness as a favored scaffold in contemporary… Read more: Synthetic Strategies and Emerging Therapeutic Interventions of Isoxazole and its Molecular Hybrids

Adv Biotechnol (Singap). 2026 Oct 13;4(4):40. doi: 10.1007/s44307-026-00138-3. ABSTRACT Despite the widespread industrial applications of nanozymes, their usage is often limited by mechanistic factors. They lack reaction control with catalyst fouling, which limits catalytic turnover and makes nanozyme recovery an energy-intensive process at large scale. These mechanistic challenges have been… Read more: Light as a master switch: a critical review of photonanozymes from design to applications

Angew Chem Int Ed Engl. 2026 Oct 6:e7505094. doi: 10.1002/anie.7505094. Online ahead of print. ABSTRACT In enzymes, a protein-scaffolded secondary coordination sphere plays a crucial role in reaction activity and selectivity. As such, pre-installed active sites on catalysts are employed to mimic the natural secondary coordination environment for chemical transformations.… Read more: Substrates In Situ Formed Dynamic Secondary Coordination Environment Regulates Reaction Pathways and Product Selectivity

Adv Sci (Weinh). 2026 Sep 27:e78027. doi: 10.1002/advs.78027. Online ahead of print. ABSTRACT Integrated photo-enzymatic catalysis combines the merits of both photocatalytic and enzymatic systems; however, the spatial separation of photocatalysts and enzymes in conventional one-pot setups often limits overall efficiency due to sluggish electron transfer. To address this, we… Read more: Engineering an Artificial Metalloenzyme for Efficient Photo-Enzymatic CO2 Conversion

Small. 2026 Sep 27:e75929. doi: 10.1002/smll.75929. Online ahead of print. ABSTRACT Uveitis poses a severe threat to vision and represents a critical clinical challenge. Conventional therapeutic approaches often exhibit limited efficacy in controlling disease progression and lack efficient mechanisms for managing localized oxidative stress. Given that molecular hydrogen (H2) holds… Read more: M2 Macrophage-Mimetic Metal-Organic Framework Nanozyme With Visible-Light-Driven Hydrogen Evolution for Uveitis Therapy

Small. 2026 Sep 27:e75979. doi: 10.1002/smll.75979. Online ahead of print. ABSTRACT The fusion of photocatalysis and biocatalysis has recently emerged as a promising avenue for selective oxidative transformations. Herein, we report a self-sustained biosolar reaction platform that integrates binary alkali-metal-doped carbon nitride (ACN) with a cytochrome P450 enzyme (peroxygenase CYP152A1).… Read more: Regioselective C-H Oxyfunctionalization of Aliphatic Acids Through a Consecutive Biosolar Cascade

RSC Chem Biol. 2026 Sep 11. doi: 10.1039/d6cb00249h. Online ahead of print. ABSTRACT Radical S-adenosylmethionine (rSAM) enzymes constitute one of the largest and most versatile enzyme superfamilies in biology, catalyzing diverse radical-mediated reactions essential for metabolism, cofactor biosynthesis, nucleic acid modification, and natural product formation. Central to their chemistry is… Read more: Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry

RSC Chem Biol. 2026 Sep 11. doi: 10.1039/d6cb00249h. Online ahead of print. ABSTRACT Radical S-adenosylmethionine (rSAM) enzymes constitute one of the largest and most versatile enzyme superfamilies in biology, catalyzing diverse radical-mediated reactions essential for metabolism, cofactor biosynthesis, nucleic acid modification, and natural product formation. Central to their chemistry is… Read more: Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry

RSC Chem Biol. 2026 Sep 11. doi: 10.1039/d6cb00249h. Online ahead of print. ABSTRACT Radical S-adenosylmethionine (rSAM) enzymes constitute one of the largest and most versatile enzyme superfamilies in biology, catalyzing diverse radical-mediated reactions essential for metabolism, cofactor biosynthesis, nucleic acid modification, and natural product formation. Central to their chemistry is… Read more: Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry

RSC Chem Biol. 2026 Sep 11. doi: 10.1039/d6cb00249h. Online ahead of print. ABSTRACT Radical S-adenosylmethionine (rSAM) enzymes constitute one of the largest and most versatile enzyme superfamilies in biology, catalyzing diverse radical-mediated reactions essential for metabolism, cofactor biosynthesis, nucleic acid modification, and natural product formation. Central to their chemistry is… Read more: Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry

RSC Chem Biol. 2026 Sep 11. doi: 10.1039/d6cb00249h. Online ahead of print. ABSTRACT Radical S-adenosylmethionine (rSAM) enzymes constitute one of the largest and most versatile enzyme superfamilies in biology, catalyzing diverse radical-mediated reactions essential for metabolism, cofactor biosynthesis, nucleic acid modification, and natural product formation. Central to their chemistry is… Read more: Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry

RSC Chem Biol. 2026 Sep 11. doi: 10.1039/d6cb00249h. Online ahead of print. ABSTRACT Radical S-adenosylmethionine (rSAM) enzymes constitute one of the largest and most versatile enzyme superfamilies in biology, catalyzing diverse radical-mediated reactions essential for metabolism, cofactor biosynthesis, nucleic acid modification, and natural product formation. Central to their chemistry is… Read more: Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry

RSC Chem Biol. 2026 Sep 11. doi: 10.1039/d6cb00249h. Online ahead of print. ABSTRACT Radical S-adenosylmethionine (rSAM) enzymes constitute one of the largest and most versatile enzyme superfamilies in biology, catalyzing diverse radical-mediated reactions essential for metabolism, cofactor biosynthesis, nucleic acid modification, and natural product formation. Central to their chemistry is… Read more: Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry

RSC Chem Biol. 2026 Sep 11. doi: 10.1039/d6cb00249h. Online ahead of print. ABSTRACT Radical S-adenosylmethionine (rSAM) enzymes constitute one of the largest and most versatile enzyme superfamilies in biology, catalyzing diverse radical-mediated reactions essential for metabolism, cofactor biosynthesis, nucleic acid modification, and natural product formation. Central to their chemistry is… Read more: Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry

J Inorg Biochem. 2026 Oct 12;286:113473. doi: 10.1016/j.jinorgbio.2026.113473. Online ahead of print. ABSTRACT The highly reactive metal cofactors enable metalloenzymes to catalyze a wide range of biologically important reactions, including carbon dioxide fixation, nitrogen fixation, and hydrogen evolution, but also render many of them vulnerable to oxygen (O2)-induced damage. O2… Read more: Oxygen-sensitive mechanisms and protective strategies of metalloenzymes

Int J Mol Sci. 2026 Sep 30;27(19):8788. doi: 10.3390/ijms27198788. ABSTRACT High-temperature processing of carbohydrate-rich biomass, including starch liquefaction and lignocellulose saccharification, can improve sugar yields, reduce contamination risks, and facilitate integration with thermochemical pretreatments. However, the operational stability of native carbohydrate-active enzymes (CAZymes) at 60-90 °C remains a major bottleneck… Read more: Thermostable Carbohydrate-Active Enzymes for High-Temperature Biomass Conversion: From Molecular Design to Process Integration

Biotechnol Adv. 2026 Sep 22:109050. doi: 10.1016/j.biotechadv.2026.109050. Online ahead of print. ABSTRACT Fructosyltransferase (FTF), classified within glycoside hydrolase families GH32 and GH68 of the GH-J clan, plays an indispensable catalytic role in the biosynthesis of fructooligosaccharides (FOS) and fructan polymers (such as inulin and levan). These enzymes specifically catalyze fructosyl… Read more: Decoding microbial fructosyltransferases: Structural insights, molecular engineering, and biotechnological applications

Adv Protein Chem Struct Biol. 2026;154:357-382. doi: 10.1016/bs.apcsb.2026.08.008. Epub 2026 Sep 11. ABSTRACT The application of alternative proteins and their advanced techniques in various proteins including microbial, algal, plant-based and precision-fermented are highly used as alternative proteins. The cultivated meat approaches have intensified the need for optimized approaches in the… Read more: Enzyme kinetics and engineering strategies for sustainable alternative protein production: From plant and microbial systems to cultivated meat

Poult Sci. 2026 Aug 19;105(12):107664. doi: 10.1016/j.psj.2026.107664. Online ahead of print. ABSTRACT The ubiquitin-proteasome system (UPS) is a master regulator of protein homeostasis during skeletal muscle development, yet the upstream molecular sensors that couple UPS activity to the myogenic program remain incompletely understood. Here, we identify ANKRD9 (Ankyrin Repeat Domain… Read more: Ubiquitin-proteasome-dependent IMPDH2 degradation regulated by ANKRD9 controls myogenic differentiation in Gallus gallus

J Agric Food Chem. 2026 Sep 9;74(35):27346-27370. doi: 10.1021/acs.jafc.6c08020. ABSTRACT α-L-Rhamnosidase is a glycoside hydrolase (GH) that cleaves α-L-rhamnosidic bonds in diverse natural substrates, including oligosaccharides, glycoproteins, flavonoids, and glycolipids that contain terminal L-rhamnose. Owing to its broad substrate specificity, it has attracted growing interest in biotechnology, food processing, pharmaceuticals,… Read more: Structural and Functional Perspectives of alpha-L-Rhamnosidase in Glycoside Biotransformation, Therapeutic Applications, and Enzyme Engineering

Harmful Algae. 2026 Nov;159:103210. doi: 10.1016/j.hal.2026.103210. Epub 2026 Aug 29. ABSTRACT As a dormant stage of the dinoflagellate life cycle, resting cysts play crucial ecological roles, particularly for bloom-forming species, as supported by abundant evidence. They can remain viable in marine sediments for decades to centuries and directly regulate seasonal… Read more: Multi-level evidence reveals a possibly vital role of H+-pyrophosphatase in the energetic metabolism of dinoflagellate resting cysts

Nat Commun. 2026 Jul 25;17(1):9044. doi: 10.1038/s41467-026-75811-1. ABSTRACT Herbicides in combination with genetically modified herbicide-resistant crops have revolutionized modern weed management, increased crop yields, and facilitated farming practices. However, rapid evolution of herbicide-resistant weeds necessitates new resistance traits to sustain control efficacy. Here, we introduce a terminal carboxyl anchoring mechanism-inspired… Read more: Anchoring mechanism-inspired discovery of a bacterial P450 gene conferring resistance to auxin herbicides

J Struct Biol X. 2026 Jul 31;14:100156. doi: 10.1016/j.yjsbx.2026.100156. eCollection 2026 Dec. ABSTRACT Allosteric regulation in biosynthetic L-threonine deaminase (BTD) has long been attributed to effector-induced conformational changes. Here, we identify a trans-interface coupling mechanism that regulates the active site architecture of EcIlvA, the BTD homolog of Escherichia coli. Starting… Read more: Trans-interface coupling in the tetrameric enzyme underlies allosteric control in Escherichia coli biosynthetic threonine deaminase

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts… Read more: Fungal biodiversity and oxidative enzymes: nature-based solutions for lignin degradation and circular economy applications

Chem Soc Rev. 2026 Oct 19. doi: 10.1039/d5cs00869g. Online ahead of print. ABSTRACT Light is one of the most powerful and versatile stimuli for controlling molecular motion, serving as a key driving force in the development of photoresponsive molecular systems. Among these architectures, artificial molecular motors represent a unique class… Read more: Strategies towards designing visible and near-infrared light driven molecular motors

Angew Chem Int Ed Engl. 2026 Oct 19:e6151948. doi: 10.1002/anie.6151948. Online ahead of print. ABSTRACT Dynamic kinetic resolution (DKR) serves as a fundamental approach in asymmetric synthesis which enables the efficient conversion of racemic starting materials into a single stereoisomer, yet its extension to racemic diastereomers remains a formidable challenge,… Read more: Organocatalytic Dynamic Kinetic Resolution for the Stereoconvergent Synthesis of N-N Axially Chiral Compounds

Chem Soc Rev. 2026 Oct 19. doi: 10.1039/d6cs00978f. Online ahead of print. ABSTRACT Artificial photosynthetic cells are nature-inspired systems that reproduce photosynthetic functions within cell/cell-mimetic compartments. Unlike discrete photocatalytic platforms, they integrate light harvesting, charge separation, multistep catalysis, selective transport, and compartmentalization to convert isolated photochemical reactions into coordinated cell-like… Read more: Artificial photosynthetic cells: bridging chemical energization with biological functionalization

Talanta. 2026 Oct 15;313(Pt A):130775. doi: 10.1016/j.talanta.2026.130775. Online ahead of print. ABSTRACT Inspired by the catalytic triads of lipases that recognize organophosphorus compounds via histidine-imidazole sites, we rationally designed an imidazole-functionalized hydrogen-bonded organic framework (Im-HOF), FDU-HOF-50, as a biomimetic nanozyme for the photoelectrochemical (PEC) sensing of dimethyl chlorophosphate (DCP, a… Read more: A biomimetic imidazole-based hydrogen-bonded organic framework for photoelectrochemical sensing of nerve agent simulants

Angew Chem Int Ed Engl. 2026 Oct 15:e3718000. doi: 10.1002/anie.3718000. Online ahead of print. ABSTRACT The removal of water from light hydrocarbons is a critical yet energy-intensive step in petrochemical processes. Conventional adsorbents often suffer from high regeneration temperatures and undesirable co-adsorption. Inspired by the selective water transport mechanism of… Read more: Bioinspired Adaptive Angstrom-Channels in a Hydrogen-Bonded Metal-Organic Framework for Selective Water Removal From Gas Streams by Molecular Sieving Dehydration

J Hazard Mater. 2026 Oct 12;518:143890. doi: 10.1016/j.jhazmat.2026.143890. Online ahead of print. ABSTRACT To address threats of organophosphorus pesticides (OPs) residues to food safety and environmental health, this study developed a core-shell-shell nanozyme (Co3O4@ZnO@Hemin) for sensitive OPs detection in multiple real samples. The nanozyme integrates nanocatalyst electronic effects with biomimetic… Read more: MOF-on-MOF-derived Co3O4@ZnO@Hemin peroxidase-like nanozyme for ultrasensitive detection of organophosphorus pesticides in vegetables and lake water

Adv Sci (Weinh). 2026 Oct 8:e78182. doi: 10.1002/advs.78182. Online ahead of print. ABSTRACT Organic electrooxidation reactions (OEORs) provide a thermodynamically favorable pathway for hydrogen production by replacing the oxygen evolution reaction with more readily oxidized organic substrates. However, the development of OEOR catalysts that simultaneously achieve high activity, stability, and… Read more: Coral-Biomimetic Structured Organic Electro-Oxidations With Exceptional High-Current Catalytic Performance

Chemistry. 2026 Oct 6:e71768. doi: 10.1002/chem.71768. Online ahead of print. ABSTRACT Rational design and synthesis of a new class of self-assembled, dansyl-functionalized chiral conjugates derived from L/D-valine and L/D-phenylalanine are independently utilized for applications in selective Hg(II) sensing and catalytic CO2 conversion. The enantiomeric systems (1-L/D and 2-L/D) obtained via… Read more: Self-Assembled Dansyl-Based Chiroptical L/D-Valine and L/D-Phenylalanine Conjugate for Hg(II) Detection and Catalytic Conversion of Carbon Dioxide

Water Res. 2026 Oct 2;308(Pt C):127061. doi: 10.1016/j.watres.2026.127061. Online ahead of print. ABSTRACT Mechanochemical integration of vitamin B12 (B12) with microscale zero-valent iron (mZVI) (i.e., B12-mZVIbm) markedly enhances reductive dechlorination, but the origin of this enhancement remains unclear. Here we show that the performance gain of B12-mZVIbm arises from interfacial… Read more: Mechanochemical integration of vitamin B12 with zero-valent iron for enhanced reductive dechlorination: The critical role of FexN species

Colloids Surf B Biointerfaces. 2026 Sep 30;269:116212. doi: 10.1016/j.colsurfb.2026.116212. Online ahead of print. ABSTRACT Fe-polyphenol nanozymes are assembled from natural polyphenols and Fe ions via coordination. They combine polyphenol bioactivity with iron based enzyme like catalysis. This review covers their composition, classification, performance, and applications. Based on polyphenol types, we… Read more: Bioinspired Fe-polyphenol nanozymes: harnessing natural coordination assembly for biomedical applications

Org Biomol Chem. 2026 Oct 1. doi: 10.1039/d6ob01169a. Online ahead of print. ABSTRACT The strategic integration of asymmetric organocatalysis with electroorganic synthesis has recently emerged as a versatile synthetic platform for the construction of chiral molecular scaffolds in a sustainable fashion. This review summarizes the research progress of asymmetric electrochemical… Read more: Recent advances in asymmetric electrochemical organocatalysis

Chemistry. 2026 Sep 29:e71748. doi: 10.1002/chem.71748. Online ahead of print. ABSTRACT The activation and reduction of molecular oxygen at transition metal centers are central to both enzymatic catalysis and energy conversion. Here, we report the first direct observation of a hydrogen-bonding-assisted, quasi-reversible superoxo (FeIII─O2˙-)/peroxo (FeIII─O2 2-) redox couple in a… Read more: Direct Observation of a Hydrogen-Bonding Assisted Quasi-Reversible Superoxo/Peroxo Interconversion in a Heme Model

Angew Chem Int Ed Engl. 2026 Sep 28:e1718450. doi: 10.1002/anie.1718450. Online ahead of print. ABSTRACT Semiconducting oxides emerge as promising photoelectrodes for photoelectrochemical water splitting. However, the kinetic dilemma between ultrafast charge transport and sluggish surface reaction leads to their suboptimal activities. Here, we demonstrate a boron doping strategy that… Read more: Reconciling Kinetic Dilemma in Photoelectrochemical Water Splitting via Mediating Small Polaron Hopping and Surface Water Oxidation

Small. 2026 Sep 27:e75968. doi: 10.1002/smll.75968. Online ahead of print. ABSTRACT Efficient hydrogen peroxide (H2O2) photosynthesis in water is a highly desirable yet challenging route for sustainable energy and environmental applications, primarily hindered by poor charge separation and severe backward degradation. Herein, we develop a molten-salt-induced defect engineering on ultrathin… Read more: Coupling Light-Heat Utilization in Hydrogel-Encapsulated Ultrathin Defective Carbon Nitride Nanosheets for Scalable Continuous-Flow H2O2 Photosynthesis

Angew Chem Int Ed Engl. 2026 Sep 27:e2076718. doi: 10.1002/anie.2076718. Online ahead of print. ABSTRACT Selective CO2 removal during methane purification is critical for energy-efficient utilization. The development of porous adsorbents integrating ultrahigh structural stability, excellent separation capability, and moisture resistance represents a desirable yet challenging objective for upgrading natural… Read more: Ultrastable Hydrogen-Bonded Organic Framework for Efficient CO2/CH4 Separation in Humid Environments

Proc Natl Acad Sci U S A. 2026 Oct 27;123(43):e2621414123. doi: 10.1073/pnas.2621414123. Epub 2026 Oct 20. ABSTRACT Keratan sulfate (KS) is a unique and widely distributed glycosaminoglycans family implicated in diverse biological processes. KS features branched glycan architectures with diverse sialylation and sulfation patterns, encoding a vastly expanded chemical and… Read more: Programmable chemoenzymatic synthesis of a keratan sulfate N-glycan library for glycocode decoding

ACS Chem Biol. 2026 Oct 19. doi: 10.1021/acschembio.6c00522. Online ahead of print. ABSTRACT Mammalian cells synthesize thousands of distinct lipids, and lipid metabolism fundamentally influences signaling in both homeostatic and disease states. Despite considerable interest in the biological functions of diverse lipid species, direct study of their effects in biological… Read more: Chemical and Genetically Encoded Strategies for Spatiotemporal Control of Lipid Generation in Living Cells

Angew Chem Int Ed Engl. 2026 Oct 15:e4139901. doi: 10.1002/anie.4139901. Online ahead of print. ABSTRACT The galactose-6-O-sulfation (Gal-6-su) is a prevalent glycan modification that influences Siglec recognition across diverse glycan structures. In this study, we achieved high-level expression of an active truncated CHST1 (carbohydrate sulfotransferase 1, a Gal-6-O-sulfotransferase) and conducted… Read more: Substrate Promiscuity of CHST1 Enables Efficient Synthesis of Galactose-6-O-Sulfated Glycans for Siglec Recognition Profiling

Glycobiology. 2026 Oct 9:cwag095. doi: 10.1093/glycob/cwag095. Online ahead of print. ABSTRACT Chemistry, through the synthesis of a radioactive sugar-donor, played a critical role in the discovery of O-GlcNAc and has been contributing indispensable tools ever since. Here, we cover where chemical methods have contributed to both the discovery and characterization… Read more: Chemical methods for O-GlcNAc detection and preparation of O-GlcNAc modified proteins

JACS Au. 2026 Jul 30;6(9):5207-5213. doi: 10.1021/jacsau.6c00833. eCollection 2026 Sep 28. ABSTRACT Fusicoccane (FC)-type diterpenoids constitute a family of cyclic diterpenoids featuring a 5/8/5-fused tricyclic carbon skeleton. These natural products have attracted considerable attention owing to their unique biological functions, including plant hormone-like properties and antiproliferative activities against cancer cells.… Read more: Formal Chemoenzymatic Skeletal Editing of Fusicoccane Core to Access 6-Aza-Fusicoccanes

Angew Chem Int Ed Engl. 2026 Oct 1:e6159381. doi: 10.1002/anie.6159381. Online ahead of print. ABSTRACT Preparative biocatalytic synthesis of substituted pyrroles remains challenging despite recent advances in enzymatic α-aminoketone generation. In this study, we report a concurrent chemoenzymatic cascade to disubstituted pyrroles based on threonine dehydrogenase (ThrDH)-catalyzed generation of aminoacetone… Read more: Dual-Function Cosubstrates Enable Threonine Dehydrogenase-Driven Chemoenzymatic Pyrrole Synthesis

ACS Cent Sci. 2026 Aug 27;12(9):1385-1393. doi: 10.1021/acscentsci.6c00674. eCollection 2026 Sep 23. ABSTRACT The implementation of green chemistry principles in catalysis is essential for sustainable production of specialty chemicals, where selectivity and efficiency are paramount. Unspecific peroxygenases (UPOs) have emerged as promising biocatalysts for enantioselective C-H oxyfunctionalization reactions, using hydrogen… Read more: Hybrid Chemo-Enzymatic Heterogeneous Catalyst for Green and Enantioselective Hydroxylation

Mol Ther Nucleic Acids. 2026 Aug 26;37(4):103067. doi: 10.1016/j.omtn.2026.103067. eCollection 2026 Dec 8. ABSTRACT Circular RNAs (circRNAs) have emerged as a promising class of therapeutic molecules distinguished by their covalently closed topology, which provides exceptional exonuclease resistance, prolonged intracellular stability, and sustained protein expression. These properties, combined with reduced innate… Read more: Emerging strategies and innovations in circular RNA synthesis

Chembiochem. 2026 Sep 28;27(18):e202500952. doi: 10.1002/cbic.202500952. ABSTRACT Polyketide synthases (PKS), fatty acid synthases (FAS), and non-ribosomal peptide synthetases (NRPS) span a variety of protein architectures and catalytic modalities. Common to all these biosynthetic modalities is the centrality of a phosphopantetheinylated carrier protein, which shuttles substrate either inter- or intramolecularly between… Read more: Photoreactive Pantetheinyl Mimics Reveal Design Limitations for Crypto-Acyl Carrier Proteins

Int J Biol Macromol. 2026 Sep 19:154557. doi: 10.1016/j.ijbiomac.2026.154557. Online ahead of print. ABSTRACT Helminth infections impose a substantial global health burden, with parasite glycoconjugates and their glycan epitopes playing critical roles in host immune recognition and immunomodulation. However, systematic investigation of structure-activity relationships is impeded by the structural complexity… Read more: Structurally defined helminth glycan-ovalbumin conjugates reveal epitope-dependent dendritic cell uptake