BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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ACS Catal. 2026 Mar 23;16(7):6241-6246. doi: 10.1021/acscatal.6c00816. eCollection 2026 Apr 3. ABSTRACT Organic chloramines are an important class of compounds containing a covalent nitrogen-chlorine bond. Despite the growing interest in their applications in small molecule synthesis and polymer science, selective catalyst systems for their preparation have remained elusive. We recently discovered that the vanadium-dependent chloroperoxidase…
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Bioresour Technol. 2026 Apr 6:134575. doi: 10.1016/j.biortech.2026.134575. Online ahead of print. ABSTRACT Continuous production of bio-based products remains a significant challenge in biocatalysis. In this study, this issue is addressed by developing a novel one-step biocatalytic platform. This method leverages co-immobilization technology, which combines the efficient display of enzymes on the cell surface with the…
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Proc Natl Acad Sci U S A. 2026 Apr 14;123(15):e2516511123. doi: 10.1073/pnas.2516511123. Epub 2026 Apr 8. ABSTRACT Genome-scale metabolic models (GEMs) have become essential tools for understanding human metabolism. Here, we introduce Human2, a consensus human GEM with enhanced precision and biological relevance, which leverages large language models (LLMs) and GitHub Action checks to streamline…
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Chembiochem. 2026 Apr 14;27(7):e202500972. doi: 10.1002/cbic.202500972. ABSTRACT Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a well-established target for lowering cholesterol and is abundantly present in the extracellular space. Inhibitors of PCSK9 have achieved marked success in the clinic, but an alternative strategy for therapeutic modulation is emerging through the degradation of PCSK9. This novel strategy…
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J Am Chem Soc. 2026 Apr 8. doi: 10.1021/jacs.6c00570. Online ahead of print. ABSTRACT Photoenzymatic reduction of CO2 to formate is a promising strategy for carbon valorization, yet its efficiency is still limited by inefficient energy and mass transport. Here, we design a series of isostructural hydrogen-bonded organic frameworks (HOFs) that establish confinement effects to…
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Chembiochem. 2026 Apr 14;27(7):e70322. doi: 10.1002/cbic.70322. ABSTRACT Vanadium-dependent haloperoxidases (VHPOs) are attractive biocatalysts for halofunctionalisation chemistry, but their routine use is frequently constrained by poor soluble recombinant expression. Here, we explore protein fusion as a construct-level strategy to simultaneously improve soluble expression of the vanadium chloroperoxidase from Curvularia inaequalis (CiVCPO) and enable in situ H2O2…
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Chembiochem. 2026 Apr 14;27(7):e70313. doi: 10.1002/cbic.70313. ABSTRACT In this study, we present an investigation of the recently identified aminoacylase MsAA for the synthesis of N-acyl-L-amino acids, focusing on N-lauroyl-L-methionine. We found optimal reaction conditions at pH 8.0 and a temperature of 40-45°C with substrate concentrations of 400 mM methionine and 150 mM lauric acid. The…
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ChemSusChem. 2026 Apr 14;19(7):e202502311. doi: 10.1002/cssc.202502311. ABSTRACT This study intends to contribute to the rational eco-design of tailored new sustainable polymers with the aid of computational methods able to generate and screen new biocatalysts in silico for the synthesis or degradation of polyesters. Automatic computational workflows can be used for the rapid selection of enzymes…
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J Pharm Biomed Anal. 2026 Apr 3;277:117496. doi: 10.1016/j.jpba.2026.117496. Online ahead of print. ABSTRACT The Endoglycosidase CC N180H mutant (Endo-CC N180H) is extensively utilized in the synthesis of homogeneous glycopeptides and glycoconjugates due to its high transglycosylation activity. However, its potential in analytical glycomics remains underexplored. In this study, various structural acceptors were synthesized using…
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Microsyst Nanoeng. 2026 Apr 7;12(1):121. doi: 10.1038/s41378-026-01218-z. ABSTRACT The existing clinical approaches for breast cancer treatment still face many major issues, including poor therapeutic efficacy and high side effects. To address these challenges, we developed a folic acid-functionalized PEGylated WS2 nanosheet system loaded with copper atoms and the chemotherapeutic agent doxorubicin (so-called Cu@WS2-PEG-FA/DOX) for enhanced…