Plant Pathol J. 2026 Apr;42(2):228-233. doi: 10.5423/PPJ.NT.01.2026.0008. Epub 2026 Apr 1. ABSTRACT Lectin receptor-like kinases (LecRLKs) are plant-specific kinases that play critical roles in stress signaling. G-type LecRLKs, which possess an α-mannose-binding bulb lectin domain, are implicated in diverse stress responses; however, their roles in drought responses in pepper plants remain poorly understood. Therefore, this…

Chemistry. 2026 Apr 10:e70995. doi: 10.1002/chem.70995. Online ahead of print. ABSTRACT Posttranslational prenylation endows polypeptides with lipophilic properties, facilitating essential biological functions such as membrane targeting and signaling. Unlike linear fatty acyl groups, the branched and unsaturated structure of isoprenoids introduces complex sterics and restricted conformational degrees of freedom. These unique features enable the fine-tuning…

Org Lett. 2026 Apr 10. doi: 10.1021/acs.orglett.6c00719. Online ahead of print. ABSTRACT Halogenases offer valuable opportunities in synthetic chemistry and biocatalysis. Here, we identify two novel flavin-dependent phenolic multisite halogenases, FasVamrb99 and IdmB26, from distinct biosynthetic pathways that exhibit divergent polyhalogenation of naphthacemycin B2. Substrate screening revealed that both enzymes display robust polyhalogenation activity, enabling…

J Chem Inf Model. 2026 Apr 10. doi: 10.1021/acs.jcim.6c00350. Online ahead of print. ABSTRACT Protein O-fucosyltransferase 1 (POFUT1) catalyzes the transfer of fucose to threonine or serine residues within epidermal growth factor-like domains (EGF-LDs) and is a therapeutic target for Notch-associated O-glycosylation disorders. Unlike classical inverting glycosyltransferases, POFUT1 employs a catalytic asparagine that tautomerizes to…

Natl Sci Rev. 2026 Feb 14;13(7):nwag099. doi: 10.1093/nsr/nwag099. eCollection 2026 Apr. ABSTRACT Current biomaterial designs struggle with complex clinical and life science demands as single-function approaches are increasingly inadequate, necessitating the systematic integration of four core elements: biosafety, physiological compatibility, biomechanical matching, and biocatalytic function across hierarchical levels. This study addresses the challenge by introducing…

Adv Mater. 2026 Apr 8:e73022. doi: 10.1002/adma.73022. Online ahead of print. ABSTRACT Biocatalytic generation of reactive oxygen species (ROS) by artificial enzymes offers a promising strategy for treating diverse diseases, including pathogenic infections and malignancies. However, the sluggish ROS biocatalytic efficiency and unstable active sites have hindered their potential clinical translation. Here, inspired by natural…

Eng Life Sci. 2026 Apr 7;26(4):e70077. doi: 10.1002/elsc.70077. eCollection 2026 Apr. ABSTRACT The lipase-catalyzed oxidative functionalization of alkenes in Pickering emulsions (PE) offers a green and efficient alternative to conventional processes involving hazardous oxidants. Other investigated reaction media used for this alternative green pathway still suffer from enzyme deactivation and /or low specific reaction rate…

ACS Catal. 2026 Mar 23;16(7):6865-6879. doi: 10.1021/acscatal.6c00436. eCollection 2026 Apr 3. ABSTRACT The widespread use of xenobiotics has driven the rapid emergence of microbial degradation pathways. A prominent example is enzymes involved in the catabolism of the herbicide atrazine, which have evolved within the last few decades. Recently, we provided evidence that the second enzyme…