Int J Biol Macromol. 2026 Sep 19:154557. doi: 10.1016/j.ijbiomac.2026.154557. Online ahead of print. ABSTRACT Helminth infections impose a substantial global health burden, with parasite glycoconjugates and their glycan epitopes playing critical roles in host immune recognition and immunomodulation. However, systematic investigation of structure-activity relationships is impeded by the structural complexity and heterogeneity of helminth glycans,…

Chem Rec. 2026 Sep 16:e70254. doi: 10.1002/tcr.70254. Online ahead of print. ABSTRACT Organocatalysis has undergone remarkable conceptual expansion over the past two decades, evolving from isolated early 20th century observations into a broad platform for designing structurally diverse and functionally sophisticated catalysts. While early developments were strongly influenced by straightforward analogies to natural enzymes, recent…

Glycoconj J. 2026 Sep 16;43(1):29. doi: 10.1007/s10719-026-10228-y. ABSTRACT GlycoRNAs are a newly identified class of post‑transcriptionally modified small non‑coding RNAs that carry covalently attached N‑ and O‑linked glycans. This discovery challenges the conventional view that glycosylation is exclusive to proteins and lipids, and places RNA at the interface of glycobiology and immune recognition. Emerging evidence…

RSC Chem Biol. 2026 Sep 7. doi: 10.1039/d6cb00217j. Online ahead of print. ABSTRACT Herein we report a divergent route from a single diazido precursor to four 6-deoxy-l-altdiamides, converted on preparative scale by promiscuous C. jejuni PseI into pseudaminic acid derivatives Pse5Ac7Ac, Pse5Ac7Fm, Pse5Ac7Hb and Pse5Hb7Fm. Surface plasmon resonance revealed the 1E8 monoclonal antibody tolerates varied…

Angew Chem Int Ed Engl. 2026 Sep 15:e2218878. doi: 10.1002/anie.2218878. Online ahead of print. ABSTRACT N- and O-glycosylations are essential post-translational modifications involved in numerous physiological and pathological processes. Sulfated N- and O-glycans, commonly found on biologically important glycoproteins, serve as critical mediators of molecular recognition. However, their precise structure-function relationships remain poorly understood, primarily…

Int J Mol Sci. 2026 Sep 5;27(17):7928. doi: 10.3390/ijms27177928. ABSTRACT Enantiomerically enriched vanillin-derived cis– and trans-β-aryl-δ-iodo-γ-lactones were synthesized using a chemoenzymatic pathway based on Candida antarctica lipase B (CALB)-catalyzed transesterification of racemic (E)-4-(4′-benzyloxy-3′-methoxyphenyl)but-3-en-2-ol, followed by Claisen rearrangement, hydrolysis, iodolactonization, and deprotection. The trans orientation of substituents on the γ-lactone ring of the target compounds was…

Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly chiral ligands, whereas the Baeyer-Villiger…

Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly chiral ligands, whereas the Baeyer-Villiger…

Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly chiral ligands, whereas the Baeyer-Villiger…

Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly chiral ligands, whereas the Baeyer-Villiger…