BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Appl Microbiol Biotechnol. 2026 Apr 11. doi: 10.1007/s00253-026-13811-3. Online ahead of print. ABSTRACT A novel cold-adapted and halotolerant α-amylase gene (AmyPG2) was cloned and expressed from the marine bacterium Photobacterium gaetbulicola Gung47T. The highest activity of AmyPG2 was displayed at 25 °C and pH 8.0. In addition, the residual activity of AmyPG2 remained at approximately…
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Mol Biol Rep. 2026 Apr 11;53(1):611. doi: 10.1007/s11033-026-11781-3. ABSTRACT The field of enzyme engineering has seen significant advancements with the development of fusion enzymes, which combine the properties of different enzymes through genetic manipulation. This review explores the effects of fusion on protein properties, improved catalytic efficiency, stability, and activity, as well as enhanced protein…
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ACS Nano. 2026 Apr 11. doi: 10.1021/acsnano.5c17835. Online ahead of print. ABSTRACT Soft robots based on optically responsive smart materials have attracted extensive research interest for their unique capabilities. However, achieving adaptive, multifunctional mode switching remains challenging. Inspired by wrist rotation, considering the high response speed, miniaturization, and discrete programmability of magnetic actuators, we designed…
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Angew Chem Int Ed Engl. 2026 Apr 10:e9334343. doi: 10.1002/anie.9334343. Online ahead of print. ABSTRACT Dynamic sub-compartmentalization and internal organization are important assets of living cells to control functional complexity. Mimicking these features in artificial cells provides a platform to effectively respond to external cues by changing internal structure, thereby emulating life-like behavior. Here, we…
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Angew Chem Int Ed Engl. 2026 Apr 10:e24817. doi: 10.1002/anie.202524817. Online ahead of print. ABSTRACT Isoxazolines are an important class of heterocycles with a broad range of biological activities. One of the most prevalent synthetic strategies to access isoxazolines is through the oxidative [3+2] cycloaddition between nitrile oxides and alkenes initiated by halogenation of a…
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Biotechnol Adv. 2026 Apr 8:108895. doi: 10.1016/j.biotechadv.2026.108895. Online ahead of print. ABSTRACT Evolutionary engineering is a key strategy for obtaining industrial strains with high stress tolerance and productivity, as well as improving enzyme performance. However, low natural mutation rates, small in vitro mutation libraries, and lengthy phenotypic screening cycles constrain the further development of this…
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J Nanobiotechnology. 2026 Apr 10;24(1):340. doi: 10.1186/s12951-026-04247-y. NO ABSTRACT PMID:41964011 | DOI:10.1186/s12951-026-04247-y
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J Biosci Bioeng. 2026 Apr 9:S1389-1723(26)00095-2. doi: 10.1016/j.jbiosc.2026.03.002. Online ahead of print. ABSTRACT A microaqueous system is generally defined as a system containing a small amount of water in the bulk of a medium, yet playing a pivotal role that exists between two extreme systems: aqueous systems and nonaqueous (or anhydrous, or non-aqueous, or dry)…
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J Agric Food Chem. 2026 Apr 10. doi: 10.1021/acs.jafc.5c16525. Online ahead of print. ABSTRACT Global food insecurity remains a challenge, with 2.3 billion people worldwide experiencing food insecurity. Applications of synthetic biology offer a promising way to address this crisis through innovative and sustainable enzyme-mediated solutions. This review explores enzymology with food and agriculture systems…
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Appl Microbiol Biotechnol. 2026 Apr 10. doi: 10.1007/s00253-026-13816-y. Online ahead of print. ABSTRACT 1,4-Butanediol (1,4-BDO) is a short-chain diol with extensive applications in various industries. Traditional petroleum-based synthesis methods face challenges such as harsh reaction conditions and environmental pollution. Recent advances in bio-based 1,4-BDO synthesis harness synthetic biology tools to engineer the microbial pathways for…