Educating and Building a Broader Biocatalysis Community
Org Lett. 2026 Apr 17. doi: 10.1021/acs.orglett.6c00887. Online ahead of print. ABSTRACT The availability of an effective ene-reductase (ER) for the synthesis of Sacubitril intermediates represents a major challenge. Herein, we report the engineering of ClER and GoER utilizing three different substrates to synthesize the key Sacubitril precursor. The best performing variant, ClER M3 (M35C/Y76C/Q244G/V289P),…
Chembiochem. 2026 Apr 28;27(8):e202500960. doi: 10.1002/cbic.202500960. ABSTRACT Hyaluronan synthase (HAS) is a membrane-bound enzyme with specific multifunctional glycosyltransferase activity that catalyzes the alternating addition of UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylglucosamine (UDP-GlcNAc) to synthesize hyaluronic acid (HA). Widely found in microorganisms, vertebrate, and virus, HAS plays a vital role in HA biosynthesis, determining both its yield…
Food Chem. 2026 Apr 14;515:149253. doi: 10.1016/j.foodchem.2026.149253. Online ahead of print. ABSTRACT The chemical immobilization method typically employs glutaraldehyde to create covalent linkages between enzymes and supports. While this approach offers high stability and reusability, its lack of eco-friendliness and suboptimal biocompatibility often result in enzyme deactivation, ultimately compromising immobilization efficiency. To replace non-green linker…
Int J Biol Macromol. 2026 Apr 15:152041. doi: 10.1016/j.ijbiomac.2026.152041. Online ahead of print. ABSTRACT Polyethylene terephthalate (PET) is a widely used synthetic polyester produced from terephthalic acid (TPA) and ethylene glycol (EG), and its environmental accumulation has become a global concern. Enzymatic depolymerization has emerged as a sustainable strategy for PET recycling. However, during PET…
J Genet Genomics. 2026 Apr 15:S1673-8527(26)00134-7. doi: 10.1016/j.jgg.2026.04.006. Online ahead of print. ABSTRACT Cereal crops often exhibit a tradeoff between thermotolerance, which is important for climate adaptation, and cell elongation, which is crucial for ideal plant architecture and yield. Here, we characterize the rice mutant with dwarfing and short roots/grains 1 (Osmds1), which shows dwarfism,…
Int J Biol Macromol. 2026 Apr 16:151835. doi: 10.1016/j.ijbiomac.2026.151835. Online ahead of print. NO ABSTRACT PMID:41997774 | DOI:10.1016/j.ijbiomac.2026.151835
J Mater Chem B. 2026 Apr 16. doi: 10.1039/d6tb00112b. Online ahead of print. ABSTRACT A high-performance organic photoelectrochemical transistor (OPECT) sensor was successfully constructed based on a ZnCdS/Ce-MOF composite gate integrated with a self-replicating catalytic hairpin assembly (SRCHA) signal-amplification strategy, which enables ultrasensitive and highly selective detection of the pesticide imidacloprid. The sensor employs visible-light-responsive…
Biochem Biophys Res Commun. 2026 Apr 12;817:153750. doi: 10.1016/j.bbrc.2026.153750. Online ahead of print. ABSTRACT Malonyl-CoA is a key precursor for the biosynthesis of numerous active natural products. Malonyl-CoA synthetases (MatBs) provide a direct route to malonyl-CoA from malonic acid and CoA. However, the limited availability of plant MatBs with high catalytic efficiency restricts their application…
Nat Commun. 2026 Apr 15. doi: 10.1038/s41467-026-72061-z. Online ahead of print. ABSTRACT Chemoenzymatic cascades, which combine the merits of enzymatic catalysis and chemical catalysis, have blossomed into a powerful technology for new-to-nature reactions. The diffusion resistance of reaction intermediates is a major rate-limiting factor in cascade reactions, which can be reduced by integrating metal catalytic…
RSC Chem Biol. 2026 Apr 14. doi: 10.1039/d6cb00050a. Online ahead of print. ABSTRACT Naphthalene, an abundant polycyclic aromatic hydrocarbon (PAH) often emitted as an industrial byproduct, represents a significant yet underutilized carbon feedstock for chemical synthesis. Due to its high chemical stability and hydrophobicity, conventional physicochemical treatment methods are often energy-intensive, condition-dependent, and prone to…