Front Mol Biosci. 2026 Apr 7;13:1715499. doi: 10.3389/fmolb.2026.1715499. eCollection 2026. ABSTRACT BACKGROUND: The traditional explanation of metabolic acidosis in extrahepatic tissues is the increased cellular production of lactic acid. We tested whether the LDH reaction produces lactate and pyruvate anions, or acids, and measured the pH changes that occur for either direction of the reaction.…

Small Sci. 2026 Mar 15;6(3):e202500237. doi: 10.1002/smsc.202500237. eCollection 2026 Mar. ABSTRACT Eukaryotic Argonautes (eAgos) are well-known for their role in utilizing RNA guides to recognize and cleave RNA targets, thereby participating in posttranscriptional regulation and RNA interference. However, it remains unclear whether certain eAgos can also cleave DNA at mesophilic temperatures. Here, we describe a…

Int J Biol Macromol. 2026 Apr 20:152149. doi: 10.1016/j.ijbiomac.2026.152149. Online ahead of print. ABSTRACT Rheum palmatum L. is a high-value, multipurpose species widely recognized for its dual utility as both a medicinal and edible plant, possessing significant economic importance across temperate regions. Its primary bioactive constituents, anthraquinone glycosides, exhibit potent pharmacological properties, including anti-inflammatory, hepatoprotective,…

Int J Biol Macromol. 2026 Apr 20:152137. doi: 10.1016/j.ijbiomac.2026.152137. Online ahead of print. ABSTRACT In this study, biobased green polymer, i.e. high surface area (370m2/g) chitin nanocrystals (ChNC) were isolated and functionalized via acylation of antifoulents (palmitic and stearic acid) were and used as catalyst for hydrolysis. To limite enzyme activation, dextranase was immobilized via…

J Hazard Mater. 2026 Apr 20;510:142153. doi: 10.1016/j.jhazmat.2026.142153. Online ahead of print. ABSTRACT The development of enzyme carriers capable of concurrently enriching hydrophobic pollutants and facilitating efficient aqueous-phase biocatalysis is crucial for advanced wastewater treatment. Conventional inorganic mesoporous supports, with their uniformly hydrophilic or hydrophobic surfaces, are fundamentally limited in achieving this dual function. To…

ACS Appl Mater Interfaces. 2026 Apr 22. doi: 10.1021/acsami.6c03853. Online ahead of print. ABSTRACT Membraneless compartments, such as coacervates, have emerged as powerful biomimetic models of protocells and fundamental regulators of the spatiotemporal organization of biochemical processes in living systems. The sticker-spacer framework offers a reductionist yet predictive approach for understanding and programming liquid-liquid phase…

Biosci Biotechnol Biochem. 2026 Apr 22:zbag050. doi: 10.1093/bbb/zbag050. Online ahead of print. ABSTRACT Phenylpyruvic acid is a high-value α-keto acid with broad applications in pharmaceutical and chemical industries. Traditional production via chemical synthesis or transaminase-mediated L-phenylalanine conversion is limited by cost and environmental concerns. Four biosynthetic schemes for phenylpyruvic acid production were evaluated. In scheme…

Chembiochem. 2026 Apr 28;27(8):e70320. doi: 10.1002/cbic.70320. ABSTRACT Photobiocatalysis with photoautotrophic whole cells has demonstrated strong potential for producing chiral molecules and platform chemicals using sustainable inputs such as light, water and CO2 under mild reaction conditions. Coupling enzymatic transformations directly to natural photosynthesis enables higher atom efficiency compared with heterotrophic systems. However, large-scale application remains…