Enzyme Microb Technol. 2026 Apr 23;199:110883. doi: 10.1016/j.enzmictec.2026.110883. Online ahead of print. ABSTRACT The synthesis of chiral alcohols is crucial for pharmaceutical applications. This study employed ion gelation and biomimetic mineralization to co-immobilize glucose dehydrogenase (GDH) and carbonyl reductase (CR), producing a chitosan-calcium pyrophosphate hybrid nanoflower enzyme (CR/GDH-@Ca₂P₂O₇) for synthesizing the chiral alcohol compound ethyl…

Bioresour Technol. 2026 Apr 23:134708. doi: 10.1016/j.biortech.2026.134708. Online ahead of print. ABSTRACT Xylooligosaccharides (XOS) are prebiotic oligosaccharides that can be efficiently produced through enzymatic hydrolysis. Therefore, the oriented control of the degree of polymerization (DP) of oligosaccharides obtained through enzymatic hydrolysis is a crucial research aspect, as oligosaccharides with lower DP exhibit superior biological activity.…

Curr Opin Chem Biol. 2026 Apr 24;92:102687. doi: 10.1016/j.cbpa.2026.102687. Online ahead of print. ABSTRACT Enzyme cascades enable streamlined multi-step biocatalysis in one-pot systems, offering remarkable efficiency, selectivity, and sustainability compared to traditional chemical synthesis. This review highlights recent advances across three major directions: (i) efficient synthesis of bulk and chiral chemicals, including alcohol-to-amine conversion, polymer…

Chembiochem. 2026 Apr 28;27(8):e70346. doi: 10.1002/cbic.70346. ABSTRACT Selective metal ion affinity binding as a simple and renewable enzyme immobilization was investigated using the same affinity function on various supports. Phenylalanine ammonia-lyase from parsley (PcPAL) and an amine transaminase from Vibrio fluvialis (VfTA) with His-tag were used as model enzymes. Metal ion chelating groups on the…

Compr Rev Food Sci Food Saf. 2026 May;25(3):e70489. doi: 10.1111/1541-4337.70489. ABSTRACT Sugar kelp (Saccharina latissima) cultivation is rapidly expanding globally, creating an abundant and geographically diverse feedstock whose processing has not kept up with cultivation. This review addresses that gap with a carbohydrate-centric scope around alginate, fucoidan, laminarin, and cellulose, integrating the latest literature with…

Chembiochem. 2026 Apr 28;27(8):e70294. doi: 10.1002/cbic.70294. ABSTRACT S-adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) are generally classified as C-, O-, N-, S-, or halide MTs depending on their methyl acceptor. C-MTs catalyze selective methylation reactions of carbon nucleophiles and play a crucial role in the regulation and diversification of natural products. The control of chemoselectivity by these enzymes…

Nat Commun. 2026 Apr 24. doi: 10.1038/s41467-026-72237-7. Online ahead of print. ABSTRACT Protein lipidation is a critical post-translational modification, but the relationship between the fine structure of fatty acids (FAs) and the specificity of lipidation remains largely unexplored. Here, we develop an enzyme-centric chemoproteomic strategy to elucidate the intricate relationships between the key players involved…

Nat Commun. 2026 Apr 24. doi: 10.1038/s41467-026-71006-w. Online ahead of print. ABSTRACT Bacteria adjust their metabolism to the cellular energy state. AMP-forming acetyl-CoA-synthetase AcsA generates acetyl-CoA from acetate, ATP and CoA. In Bacilli, including Bacillus subtilis and Geobacillus stearothermophilus, AcsA is reversely transcribed upstream of the acu-operon encoding for the proteins AcuA, AcuB and AcuC.…

BMC Complement Med Ther. 2026 Apr 25. doi: 10.1186/s12906-026-05377-4. Online ahead of print. NO ABSTRACT PMID:42032545 | DOI:10.1186/s12906-026-05377-4

J Biol Chem. 2026 Apr 22:111483. doi: 10.1016/j.jbc.2026.111483. Online ahead of print. ABSTRACT Tungsten-dependent formate dehydrogenases catalyze the reversible interconversion of CO2 and formate and play key roles in microbial redox metabolism, yet the molecular basis for selective tungsten cofactor assembly in aerobic bacteria remains poorly understood. Here, we define a dedicated tungsten-specific maturation pathway…