Trends Biotechnol. 2026 Apr 23:S0167-7799(26)00135-6. doi: 10.1016/j.tibtech.2026.03.026. Online ahead of print. ABSTRACT Establishing efficient cell factories involves a continuous process of trial and error due to metabolic complexity. This complexity makes predicting effective engineering targets a challenging task. Therefore, successful previous designs are vital for future cell factory development. In this study, we developed a…

Chembiochem. 2026 Apr 28;27(8):e70351. doi: 10.1002/cbic.70351. ABSTRACT Unspecific peroxygenase (UPO) is versatile fungal enzyme that carries out with high efficiency a plethora of C-H oxyfunctionalizations of organic compounds, simply triggered by H2O2. With the goal of making UPO an industrial biocatalyst, it has been subjected over the years to different directed evolution campaigns focused on…

ACS Appl Mater Interfaces. 2026 Apr 23. doi: 10.1021/acsami.6c02964. Online ahead of print. ABSTRACT Androgenetic alopecia (AGA) is characterized by follicular miniaturization mediated by androgens along with chronic inflammatory and vascular disturbances. These alterations suggest broader dysregulation involving endocrine pathways, immune activity, and vascular function. Current therapies such as finasteride and minoxidil provide limited and…

Phys Chem Chem Phys. 2026 Apr 24. doi: 10.1039/d5cp04574f. Online ahead of print. ABSTRACT Bacterial cytochrome P450s are cornerstone monooxygenases that enable selective oxidation across the fields of metabolism and biocatalysis. Yet, for the orphan Bacillus subtilis enzyme CYP134A1 (CypX), how ligand identity governs conformational readiness remains unclear despite its solved structure. Here we combine…

Angew Chem Int Ed Engl. 2026 Apr 24:e26152. doi: 10.1002/anie.202526152. Online ahead of print. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different pharmacological and toxicological profiles. Although the importance of stereochemistry in drug efficacy is well established, its role in drug metabolism and disposition remains comparatively underexplored, despite…

Synth Syst Biotechnol. 2026 Apr 16;14:89-100. doi: 10.1016/j.synbio.2026.03.022. eCollection 2026 Dec. ABSTRACT Bioplastic poly(3-hydroxybutyrate) (PHB) production by Halomonas bluephagenesis is typically activated under nitrogen limitation, inevitably restricting biomass formation and overall productivity. Here we identified gene ilvA encoding threonine deaminase as a flux-sensitive node linking branched-chain amino-acid synthesis to nitrogen sensing. Complete ilvA deletion or…

ACS Synth Biol. 2026 Apr 23. doi: 10.1021/acssynbio.6c00085. Online ahead of print. ABSTRACT Saccharomyces cerevisiae is an invaluable model organism for both fundamental biological research and biotechnological applications including recombinant protein production as well as protein and metabolic engineering. We previously developed a modular cloning (MoClo) based toolkit for S. cerevisiae that facilitates rapid optimization…

ACS Appl Bio Mater. 2026 Apr 23. doi: 10.1021/acsabm.6c00447. Online ahead of print. ABSTRACT The intrinsic disadvantages of natural enzymes limit their practical applications. How to achieve artificial enzymes with a green process, low cost, high stability, robust catalytic activity, and excellent biocompatibility remains a great challenge. Amyloid fibrils deserve particular attention in electron transfer…