BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Water Res. 2026 May 13;301:126121. doi: 10.1016/j.watres.2026.126121. Online ahead of print. ABSTRACT Emerging contaminant biodegradation is still interpreted mainly through pathway reconstruction, parent-compound removal, and metabolite identification. These approaches document biotransformation outcomes, but often fail to explain how degradation is initiated and routed at the protein level. Here, we reviewed probe-based, label-free, and structural chemoproteomic…
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Mol Biochem Parasitol. 2026 May 15:111759. doi: 10.1016/j.molbiopara.2026.111759. Online ahead of print. ABSTRACT Leishmania donovani ADSL is a tetrameric protein involved in the purine metabolism where the active site is formed from residues belonging to three different subunits. In this study, the amino acid residues- E334, N335 and R370 of LdADSL were studied for their…
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Curr Opin Chem Biol. 2026 May 15;93:102697. doi: 10.1016/j.cbpa.2026.102697. Online ahead of print. ABSTRACT Oligonucleotides have emerged as a rapidly expanding modality in therapeutics, diagnostics, and synthetic biology, increasing manufacturing demand. However, solid phase oligonucleotide synthesis, the dominant production technology, is hampered by cumulative yield losses as sequence length increases, poor scalability for stereochemically defined…
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Phys Rev E. 2026 Apr;113(4-1):044416. doi: 10.1103/9h19-b6ht. ABSTRACT Simplified stochastic models are widely used in the study of frequency-resolved noise propagation in biochemical reaction networks, a common measure being the coherence between random fluctuations in molecule number trajectories. Such models have also found widespread application in the quantification of how information is transmitted in reaction…
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FEBS J. 2026 May 15. doi: 10.1111/febs.70584. Online ahead of print. ABSTRACT A key step in the evolution of lignin-degrading enzymes is revealed by the observation that, unlike other heme proteins studied to date, ClassII peroxidases exhibit minimal energy transfer from tryptophan to heme residues. Bioinformatics analyses and molecular dynamics simulations (MDS) of ClassII peroxidases…
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J Hazard Mater. 2026 May 14;512:142390. doi: 10.1016/j.jhazmat.2026.142390. Online ahead of print. ABSTRACT Antibiotic-containing agricultural wastewater poses a critical challenge for simultaneous pollutant removal and carbon reduction technology. In this study, a visible-light-driven photocatalysis-microalgae (PC-MA) system was constructed by coupling WO3/α-Fe2O3/zeolite (WFZ) heterojunction with Chlorella vulgaris granules to treat simulated wastewater containing ciprofloxacin (CIP). At…
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Nat Commun. 2026 May 15;17(1):4370. doi: 10.1038/s41467-026-70868-4. ABSTRACT Polyethylene terephthalate (PET) plastic waste causes serious environmental pollution due to insufficient recycling rates. Enzymatic PET depolymerization offers a sustainable recycling strategy, but limited stability and activity of current PET-degrading enzymes restrict practical implementation. Here, we engineer Polyester Hydrolase Leipzig 7 (PHL7), a PET hydrolase from a…
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Angew Chem Int Ed Engl. 2026 May 15:e5002594. doi: 10.1002/anie.5002594. Online ahead of print. ABSTRACT Core-xylosylated N-glycans represent a ubiquitous class of N-glycans widely distributed across nature. Recently, core-xylosylated N-glycans have attracted considerable attention in the medical field, as they could elicit strong immune responses. Notably, antibodies targeting core-xylosylated N-glycans could kill Schistosoma in vitro,…
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Chem Rev. 2026 May 15. doi: 10.1021/acs.chemrev.5c00946. Online ahead of print. ABSTRACT The integration of biological catalysts with organic light-harvesting materials represents a rapidly advancing strategy for sustainable solar-to-chemical energy conversion. Recent advances demonstrate that photoexcited organic materials can effectively activate redox enzymes and whole-cell systems to catalyze fuel-forming reactions such as H2 evolution and…
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Adv Sci (Weinh). 2026 May 15:e75658. doi: 10.1002/advs.75658. Online ahead of print. ABSTRACT Traditional targeted protein degradation (TPD) strategies are largely ineffective against membrane proteins, which constitute over 60% of drug targets. To address this, we develop a modular “plug-and-play” UPTAB (Ultrahigh-affinity Protein pairs fused to Targeting Binders) platform for TPD. The platform leverages orthogonal…