Mar Pollut Bull. 2026 May 20;231:119905. doi: 10.1016/j.marpolbul.2026.119905. Online ahead of print. ABSTRACT This study provides an integrated evaluation of potentially toxic element (PTE) accumulation across nine dominant mangrove species at five sites representing industrial, residential, and protected settings in Pattani Bay, Thailand. Sediment risk indices, including enrichment factor (EF), geo-accumulation index (Igeo), and metal…

ChemSusChem. 2026 May 27;19(10):e70736. doi: 10.1002/cssc.70736. ABSTRACT Mechanochemistry and biocatalysis offer complementary routes to greener synthesis, yet their combination remains challenging, as enzymes and whole-cell systems often lose activity under low-solvent and mechanically demanding conditions. Here we demonstrate that Baker’s yeast, a widely used whole-cell biocatalyst, retains catalytic activity and high stereoselectivity under ball-milling conditions.…

J Am Chem Soc. 2026 May 21. doi: 10.1021/jacs.6c03303. Online ahead of print. ABSTRACT The convergent, stereoselective, and protecting-group-free synthesis of noncanonical amino acids, particularly those bearing a tetrasubstituted α-stereogenic center, remains a challenging task. By leveraging pyridoxal radical biocatalysis, we developed photobiocatalytic oxidative coupling methods for the assembly of α-tetrasubstituted amino acids, including β-branched…

RSC Chem Biol. 2026 May 5. doi: 10.1039/d6cb00036c. Online ahead of print. ABSTRACT Carbocyclic nicotinamide cofactors are attractive NAD(P)+ analogues that retain native redox activity while offering substantially enhanced chemical and thermal stability. Their broader use, however, has been limited by demanding multistep chemical syntheses involving complex protection strategies and limited exploration of enzymatic alternatives.…

Chembiochem. 2026 May 27;27(10):e202500892. doi: 10.1002/cbic.202500892. ABSTRACT Inorganic pyrophosphatases (PPases) are ubiquitously present in living organisms, where they prevent the pathological accumulation of inorganic pyrophosphate (PPi) in cells by catalyzing its efficient hydrolysis. This study reports the cloning, expression, and biochemical characterization of two novel thermostable soluble PPases derived from Thermoleophilia bacterium (PPaseTba) and Thermoprotei…

J Am Chem Soc. 2026 May 20. doi: 10.1021/jacs.6c00732. Online ahead of print. ABSTRACT The rational design of enzymes capable of catalyzing abiotic transformations represents a frontier in synthetic biocatalysis. While computational strategies have successfully produced enzymes for acid-base chemistry, examples of de novo designed oxidoreductases are still rare. Here, we report a deep learning-guided…

Chem Sci. 2026 May 6. doi: 10.1039/d6sc01847e. Online ahead of print. ABSTRACT The observed shift from temperature (T)-independence of hydrogen kinetic isotope effects (KIEs) in wild-type enzymes to T-dependence of KIEs in enzyme mutants has been explained as evidence for the role of protein dynamics in compressing donor (Don)-acceptor (Acc) distances (DADs) for catalysis. To…

Biotechnol Adv. 2026 May 18:108926. doi: 10.1016/j.biotechadv.2026.108926. Online ahead of print. ABSTRACT Flavin-dependent enzymes constitute one of the most versatile classes of biocatalysts, owing to the rich redox chemistry and multifunctionality of flavin cofactors. Beyond their well-established roles in natural oxidation-reduction processes, recent advances have revealed that flavoproteins exhibit remarkable catalytic promiscuity, enabling a wide…

Nat Commun. 2026 May 18;17(1):4221. doi: 10.1038/s41467-026-72705-0. ABSTRACT Nicotine is a neuroactive alkaloid produced by tobacco (Nicotiana tabacum) as a defence against herbivory, and an addictive stimulant that has been used by humans for millennia. Despite its significance, the core steps of its biosynthesis have remained elusive. Here, we demonstrate the in vitro reconstruction of…