BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Chem Soc Rev. 2026 May 13. doi: 10.1039/d4cs00071d. Online ahead of print. ABSTRACT This review summarizes recent progress in cell@MOF, cell@COF, and cell@HOF composites from a synthetic biology and materials science perspective. It outlines key synthetic strategies for the synthesis of porous abiotic exoskeletons, focusing on framework-based materials. Additionally, it discusses the cell surface chemistry…
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Pest Manag Sci. 2026 May 13. doi: 10.1002/ps.70919. Online ahead of print. ABSTRACT BACKGROUND: Phenotypic plasticity in insect wing dimorphism mediates a key trade-off between dispersal and reproduction, but how host plant nutritional cues are transduced into discrete developmental outcomes remains unclear. We investigated the role of glucose in the regulation of wing morph fate…
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Foods. 2026 Apr 30;15(9):1555. doi: 10.3390/foods15091555. ABSTRACT This review comprehensively examines the structural architecture, catalytic mechanisms, and targeted molecular engineering of α-amylase (primarily the GH13 family), a pivotal biocatalyst in the food industry. We highlight diverse microbial sources of α-amylases and their cost-effective heterologous expression in well-characterized hosts like Bacillus subtilis and Escherichia coli. To…
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Curr Opin Chem Biol. 2026 May 13;93:102696. doi: 10.1016/j.cbpa.2026.102696. Online ahead of print. ABSTRACT Modern proteomic efforts aim to define protein composition and protein-protein interactions within native spatial tissue contexts to understand disease mechanisms and therapeutic responses. Two complementary strategies dominate this effort: physically resolved mapping using high-plex imaging, mass cytometry, or laser-capture microdissection, and…
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Nat Commun. 2026 May 13. doi: 10.1038/s41467-026-72881-z. Online ahead of print. ABSTRACT Visible light photocatalysis, which exploits the reactivity of molecules at their excited state, has triggered a paradigm shift in organic synthesis by enabling some very unique chemical transformations. Yet, achieving precise control of the enantioselectivity in such processes remains a major challenge. A…
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ChemSusChem. 2026 May 14;19(9):e70698. doi: 10.1002/cssc.70698. ABSTRACT With the continuously increasing volume of textile waste and the limitations of current recycling strategies, there is a growing need for the development of environmentally sustainable and efficient processing methods. Cellulose derived from post-consumer textile waste represents a promising and cost-effective substrate for enzymatic hydrolysis due to its…
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J Am Chem Soc. 2026 May 13. doi: 10.1021/jacs.6c05246. Online ahead of print. ABSTRACT Sinefungin is a nucleoside natural product isolated from several strains of Streptomyces. The chemical structure of sinefungin is characterized by an unusual C-C bond linkage between ornithine and adenosyl fragments. Previous studies suggested that pyridoxal 5′-phosphate (PLP)-dependent enzyme catalysis is involved…
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Beilstein J Org Chem. 2026 May 5;22:683-690. doi: 10.3762/bjoc.22.53. eCollection 2026. ABSTRACT Depressin (1) is a soft coral-derived diterpenoid containing the typical bicyclo[12.1.0]pentadecane casbane skeleton and a C5-keto group. Key strategies for the synthesis of depressin, as well as its casbene skeleton reported so far focused on the formation of the challenging 14-membered ring system.…
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Biotechnol Bioeng. 2026 May 12. doi: 10.1002/bit.70236. Online ahead of print. ABSTRACT This study pioneered a whole-cell biocatalytic process using engineered Gluconobacter oxydans to produce glucaric acid (GA), a food additive, from glucuronic acid (GlcA). From a molecular perspective, molecular dynamics simulations have confirmed that van der Waals forces and hydrogen bond interactions in acidic…
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Chembiochem. 2026 May 27;27(10):e70385. doi: 10.1002/cbic.70385. ABSTRACT Fatty acyl-coenzyme A (CoA) thioesters are indispensable intermediates in primary metabolism and essential building blocks for biosynthetic pathways yielding fuels, fine chemicals, and pharmaceuticals. However, large-scale production of acyl-CoAs is frequently constrained by the intracellular availability and high cost of CoA, motivating the development of alternative strategies for…