Educating and Building a Broader Biocatalysis Community
mBio. 2026 May 29:e0074126. doi: 10.1128/mbio.00741-26. Online ahead of print. ABSTRACT Atrial fibrillation (AF) is the most prevalent clinical arrhythmia, associated with numerous complications, elevated morbidity and mortality rates, and limited therapeutic interventions, which have been confirmed to be related to the intestinal microbiota. However, there is currently limited research on the interaction between gut…
Chemistry. 2026 May 29:e71159. doi: 10.1002/chem.71159. Online ahead of print. ABSTRACT Artificial enzymes represent a promising alternative for performing non-natural reactions in biocatalysis. Here, we illustrate the potential of cross-linked enzyme crystals (CLEC) to achieve enantioselective epoxidation through the generation of an artificial enzyme obtained by direct covalent anchoring of a manganese complex as an…
Mitochondrial DNA A DNA Mapp Seq Anal. 2026 May 29:1-7. doi: 10.1080/24701394.2026.2677588. Online ahead of print. ABSTRACT Vischeria sp. WL1, an oleaginous microalga isolated from biocrusts, is a promising candidate for biofuel production due to its high lipid accumulation and tolerance to moderate salt stress. In this study, we sequenced and assembled the complete plastid…
Angew Chem Int Ed Engl. 2026 May 28:e7821033. doi: 10.1002/anie.7821033. Online ahead of print. ABSTRACT Nitro compounds are central to synthetic chemistry, yet mild and selective biocatalytic routes to these motifs remain elusive. We report an enzymatic strategy for the unique decarboxylative hydronitration of fumarate, achieved by repurposing the nitrosuccinate lyase CreD from the aspartase/fumarase…
J Agric Food Chem. 2026 May 28. doi: 10.1021/acs.jafc.6c03145. Online ahead of print. ABSTRACT Isooctyl epoxyoleate is a biobased plasticizer with excellent properties. To eliminate the risks of hydrogen peroxide storage and enzyme deactivation during the enzymatic synthesis of biobased plasticizers and reduce the separation cost of the process, we developed a greener process driven…
Angew Chem Int Ed Engl. 2026 May 28:e1454473. doi: 10.1002/anie.1454473. Online ahead of print. ABSTRACT We present a visible-light-driven photocatalytic platform based on a photosensitive metal-organic cage (PMOC), which enables selective recognition and activation of amidyl N─H bonds while suppressing competing homocoupling pathways. This system promotes a controlled intramolecular 1,5-HAT/cyclization cascade via an oxidative proton-coupled…
Adv Healthc Mater. 2026 May 28:e71286. doi: 10.1002/adhm.71286. Online ahead of print. ABSTRACT Durable tough underwater tissue adhesion presents a big challenge due to the inherent materials science trade-off between robust interfacial bonding and cohesion strength. Inspired by the synergistic adhesion mechanisms of mussel foot proteins and barnacle cement proteins, we designed and synthesized a…
N Biotechnol. 2026 May 26:S1871-6784(26)00072-5. doi: 10.1016/j.nbt.2026.05.012. Online ahead of print. ABSTRACT Vanillyl compounds are natural bioactives, but their pungency and low bioavailability limit practical use. To overcome these issues, non-pungent vanillyl esters have been developed. However, their suitability for industrial applications as bioactive materials is questionable due to toxicity concerns arising from raw materials…
J Agric Food Chem. 2026 May 27. doi: 10.1021/acs.jafc.5c12942. Online ahead of print. ABSTRACT Biocatalytic production of human milk oligosaccharides (HMOs) depends on efficient synthesis of the sugar backbone core. Previous studies engineered a D746E variant of a GH20 β-N-acetylhexosaminidase (BbhI) that appears promising for industrial synthesis of the trisaccharide HMO core precursor lacto-N-triose II…
Antioxidants (Basel). 2026 Apr 24;15(5):539. doi: 10.3390/antiox15050539. ABSTRACT Flavonoids are a broad class of polyphenolic compounds with well-established biological and therapeutic relevance; however, their clinical application is often limited by unfavorable pharmacokinetic properties, including low solubility, poor bioavailability, and extensive metabolism. Enzymatic modification has emerged as a promising strategy to overcome these limitations, enabling regio-…