Angew Chem Int Ed Engl. 2026 May 26:e2267541. doi: 10.1002/anie.2267541. Online ahead of print. ABSTRACT The cell membrane is a prime target for the introduction of novel cellular functionalities, as it is a complex system with many routes for surface modification. Several chemical coating and genetic engineering methods have thus been developed for this purpose.…

Enzyme Microb Technol. 2026 May 19;200:110902. doi: 10.1016/j.enzmictec.2026.110902. Online ahead of print. ABSTRACT The substrate specificity and synthetic applicability of Gluconobacter oxydans DSM2003 were systematically examined. G. oxydans DSM2003 catalyzed the oxidation of both aromatic and aliphatic primary alcohols to the corresponding carboxylic acids in high yields. The catalytic process proceeded through sequential action of…

Nat Biotechnol. 2026 May 26. doi: 10.1038/s41587-026-03153-w. Online ahead of print. NO ABSTRACT PMID:42191986 | DOI:10.1038/s41587-026-03153-w

Adv Sci (Weinh). 2026 May 26:e75853. doi: 10.1002/advs.75853. Online ahead of print. ABSTRACT The Fe(II)/α-ketoglutarate-dependent dioxygenase (αKGD) superfamily enables various C-H functionalization supported by their active pocket architectures composed of one or more loop elements. However, their conserved architectural features and broader functional roles across the catalytic cycle remain incompletely defined, although such loops have…

Curr Microbiol. 2026 May 26;83(7):381. doi: 10.1007/s00284-026-04958-3. ABSTRACT Vibrios have sustained various types of ocean ecosystems, being key players in marine mineral cycles and essential partners in specific groups of marine life. Observed genome plasticity and metabolic versatility are some of the unique biological features of vibrios, and these traits could contribute in expanding their…

Bioresour Technol. 2026 May 24:134967. doi: 10.1016/j.biortech.2026.134967. Online ahead of print. ABSTRACT The structural complexity and regiospecificity of ginsenosides pose significant challenges for precise biocatalysis, necessitating enzymes with finely tuned conformational control. Here, we report the high-level biomanufacturing of the rare ginsenoside F2 via computational redesign of β-glucosidase BglPp from Paenibacillus phyllosphaerae. By integrating evolutionary…

ACS Omega. 2026 May 8;11(19):27862-27874. doi: 10.1021/acsomega.5c10884. eCollection 2026 May 19. ABSTRACT This investigation, conducted within the framework of the circular economy, employed green coconut waste as a lignocellulosic substrate for the production of xylanase via solid-state fermentation (SSF). Enzymatic yield was optimized through a Box-Behnken experimental design, incorporating initial moisture content, incubation temperature, and…

Synth Syst Biotechnol. 2025 Dec 4;12:124-133. doi: 10.1016/j.synbio.2025.11.010. eCollection 2026 Jun. ABSTRACT (S)-(+)-linalool, a valuable acyclic monoterpenol secondary metabolite of plants, finds extensive applications in the food, flavor and fragrance, pharmaceutical, and daily chemical industries. Microbial synthesis offers two pathways for its production, among which the mevalonate (MVA) pathway derived from halophilic archaea is more…

3 Biotech. 2026 Jun;16(6):220. doi: 10.1007/s13205-026-04857-1. Epub 2026 May 21. ABSTRACT Xylooligosaccharides (XOS) were produced from xylan-rich agricultural residues using endo-xylanase from Thermomyces lanuginosus PC7S1T immobilized on magnetic chitosan beads. The immobilized enzyme showed high immobilization yield (90.7%), efficiency (73.7%), and activity recovery (66.8%). Enhanced stability was observed, with 94% residual activity after 50 d…

J Am Chem Soc. 2026 May 25. doi: 10.1021/jacs.6c03321. Online ahead of print. ABSTRACT Class II diterpene cyclases (DTCs) have long been recognized to mediate distal cyclization of geranylgeranyl pyrophosphate (GGPP) into bicyclic labdane-related products through an acid-base catalytic mechanism, leaving the pyrophosphate ‘head’ group intact. Although distal monocyclic diterpenoids naturally occur, these are historically…