Educating and Building a Broader Biocatalysis Community
Insects. 2026 Jun 18;17(6):643. doi: 10.3390/insects17060643. ABSTRACT Plagiodera versicolora (Coleoptera: Chrysomelidae), the willow leaf beetle, is a leaf-eating pest that generally occurs on salicaceous trees. However, there is a blank of identification and phylogenetic relationship of the detoxification genes in P. versicolora. Here, we identified four detoxification gene families (glutathione S-transferases: GSTs, UDP-glycosyltransferases: UGTs, cytochrome…
Molecules. 2026 Jun 10;31(12):2029. doi: 10.3390/molecules31122029. ABSTRACT Ferns represent an evolutionarily distinct group of vascular plants and constitute an underexplored source of structurally diverse secondary metabolites with potential medicinal value. Several fern-derived compounds, including sesquiterpenes, triterpenes, flavonoids, phloroglucinol derivatives, lactones, and glycosides, have been associated with antibacterial, antidiabetic, analgesic, anticancer, hepatoprotective, neuroprotective, and other biological…
Molecules. 2026 Jun 20;31(12):2168. doi: 10.3390/molecules31122168. ABSTRACT The genus Tamarix L. includes several species widely used in traditional medicine for their therapeutic properties. This study aims to evaluate the bioactive potential of Tamarix gallica extracts from Western Algeria using an integrated in vitro and in silico approach. GC-MS analysis with BSTFA derivatization was performed to…
Molecules. 2026 Jun 22;31(12):2189. doi: 10.3390/molecules31122189. ABSTRACT Plant cytochrome P450 monooxygenases (CYPs) are valuable biocatalysts for the regioselective hydroxylation of aromatic compounds. However, their expression in bacterial hosts is hampered by poor solubility, membrane anchoring and the requirement for redox partners. In this work, we report the design and characterization of modular expression systems that…
Front Microbiol. 2026 Jun 10;17:1847633. doi: 10.3389/fmicb.2026.1847633. eCollection 2026. ABSTRACT Antimicrobial resistance (AMR) continues to outpace the development of new anti-infective agents, particularly against priority bacterial pathogens such as Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus, as well as clinically relevant fungi including Candida auris. In this scenario, biotransformation has emerged as a…
ACS Sustain Chem Eng. 2026 Jun 8;14(24):10981-10995. doi: 10.1021/acssuschemeng.6c01404. eCollection 2026 Jun 22. ABSTRACT Enzymatic hydrolysis of poly-(ethylene terephthalate) (PET) releases mono-(2-hydroxyethyl) terephthalate (MHET) as a major product, the accumulation of which can prolong reactor residence times and complicate downstream monomer separations. The use of a MHETase enzyme can enable MHET hydrolysis to the monomers,…
JACS Au. 2026 Jun 10;6(6):3376-3385. doi: 10.1021/jacsau.6c00382. eCollection 2026 Jun 22. ABSTRACT 16α-Methyl glucocorticoids are a renowned family of steroid molecules with diverse important pharmaceutical applications, and development of innovative, practical, and divergent synthetic routes toward these steroids is highly desirable. Herein, we report a unified stereocontrolled synthesis of five 16α-methyl glucocorticoid pharmaceuticals, namely, (+)-dexamethasone,…
BioTech (Basel). 2026 May 30;15(2):40. doi: 10.3390/biotech15020040. ABSTRACT Mucic acid (MA) is used as a chelating agent or as a building block for bio-based polymers. MA can be produced by regioselective oxidation of D-galacturonic acid (GA). Gluconobacter oxydans is known for the partial oxidation of various substrates via membrane-bound dehydrogenases. As the wild-type strain shows…
J Org Chem. 2026 Jun 25. doi: 10.1021/acs.joc.6c00980. Online ahead of print. ABSTRACT A chemo-enzymatic approach to enantiopure (S)-linezolid 1 is presented. The key chiral intermediate, (R)-alcohol 4, was obtained via CRL lipase-catalyzed kinetic resolution of (RS)-4, affording an enantiopure (R)-alcohol 4 with 98.5% ees (enantiomeric excess of substrate) and an (S)-ester with 97.1% eep…
Sheng Wu Gong Cheng Xue Bao. 2026 Jun 25;42(6):2439-2453. doi: 10.13345/j.cjb.260046. ABSTRACT Due to its high selectivity, mild reaction conditions, and environmentally friendly characteristics, biocatalysis has shown important potential in the fields of fine chemical synthesis, bioenergy conversion, and environmental governance. However, biocatalysts, including enzymes and microorganisms, generally have problems such as insufficient stability, easy…