BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Biophys Rep. 2026 Jun 30;12(3):193-206. doi: 10.52601/bpr.2025.240057. ABSTRACT Potassium-chloride cotransporters KCCs mediate the coupled, electroneutral cotransport of K+ and Cl– across the membrane and are involved in important physiological processes such as cell volume regulation and γ-aminobutyric acid (GABA) and glycine-mediated inhibitory neurotransmission. Although structures of KCCs have been reported, the identification of ions bound…
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3 Biotech. 2026 Jul;16(7):283. doi: 10.1007/s13205-026-04924-7. Epub 2026 Jun 25. ABSTRACT Aspartate-α-decarboxylase (ADC) catalyzes the decarboxylation of L-aspartate to produce β-alanine, while was restricted for applications by its mechanism-based inactivation. Here the flexibility of the β-sheet containing Y58, a critical residue contributing to the mechanism-based inactivation, was rationally engineered for reducing its interaction with another…
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Bio Protoc. 2026 Jun 20;16(12):e5462. doi: 10.21769/BioProtoc.5462. eCollection 2026 Jun 20. ABSTRACT The CRISPR/Cas12a system has revolutionized molecular diagnostics; however, conventional Cas12a-based methods for RNA detection typically require transcription and pre-amplification steps. Our group has recently developed a diagnostic technique known as the SCas12a assay, which combines Cas12a with a split crRNA, achieving amplification-free detection…
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ACS Nano. 2026 Jun 29. doi: 10.1021/acsnano.6c05620. Online ahead of print. ABSTRACT Neutrophils are an ideal drug carrier because of their specific targeting and effective accumulation at sites of inflammation. However, the clinical application of neutrophils as drug carriers is constrained by the inability to sustain ex vivo culture and their short lifespan. Herein, we…
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Biomater Adv. 2026 Jun 27;188:215045. doi: 10.1016/j.bioadv.2026.215045. Online ahead of print. ABSTRACT Managing complex wounds characterized by multidrug-resistant bacterial infections and impaired vascularization remains a significant clinical challenge. This study describes the development of a multifunctional conductive organohydrogel (POBMG) based on a polyacrylamide/oxidized sodium alginate (PAM/OSA) network reinforced with magnesium-based metal-organic framework/black phosphorus (MgMOF/BP) hybrids.…
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ChemSusChem. 2026 Jul 14;19(13):e70835. doi: 10.1002/cssc.70835. ABSTRACT The development of sustainable biorefineries requires integrated fractionation strategies capable of preserving carbohydrate streams while generating high-value lignin and bioactive fractions. In this study, olive pomace was valorized through a cascade approach combining optimized microwave-assisted extraction (MAE) of phenolic compounds, natural deep eutectic solvents (NADES)-enabled pretreatment, and chemo-enzymatic…
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FEBS Lett. 2026 Jun 25. doi: 10.1002/1873-3468.70400. Online ahead of print. ABSTRACT It is important to understand how the fascinating diversity of modern enzymes has manifested itself since the onset of life. A powerful approach to address this question is the computational and experimental retracing of evolutionary processes by protein engineering techniques such as rational…
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Author Correction: The SESAME complex regulates cell senescence through the generation of acetyl-CoA
Nat Metab. 2026 Jun 26. doi: 10.1038/s42255-026-01574-0. Online ahead of print. NO ABSTRACT PMID:42362771 | DOI:10.1038/s42255-026-01574-0
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Angew Chem Int Ed Engl. 2026 Jun 26:e6159643. doi: 10.1002/anie.6159643. Online ahead of print. ABSTRACT Better enzymes are needed to develop sustainable methods to recycle plastics with C-X heterobonds such as polyurethane (PUR) and nylon, for which no industrial-scale solutions exist. Current methods rely largely on sequence mining based on a small number of known…
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Chem Commun (Camb). 2026 Jun 26. doi: 10.1039/d6cc01834c. Online ahead of print. ABSTRACT Proteins, as the primary executors of life activities, achieve essential biological functions through self-assembly into higher-order oligomers. Inspired by the sophisticated protein assembly systems in nature, the field of artificial protein assembly has developed diverse construction strategies, realizing a leapfrog progression from…