ACS Pharmacol Transl Sci. 2026 Jun 25;9(7):1726-1741. doi: 10.1021/acsptsci.6c00183. eCollection 2026 Jul 10. ABSTRACT Microplastic (MP) exposure compromises gut barrier integrity, microbial homeostasis, and host immunity to accelerate mucosal dysfunction and disease progression. This necessitates new strategies to address gut MP accumulation concerns. Unlike environmental settings, the gut imposes harsh physiological constraints that restrict conventional…

Acta Pharm Sin B. 2026 Jul;16(7):4743-4745. doi: 10.1016/j.apsb.2026.06.033. Epub 2026 Jul 8. NO ABSTRACT PMID:42453396 | PMC:PMC13366323 | DOI:10.1016/j.apsb.2026.06.033

Acta Pharm Sin B. 2026 Jul;16(7):4051-4066. doi: 10.1016/j.apsb.2026.03.052. Epub 2026 Apr 8. ABSTRACT Enzymatic reactions play an emerging role in a broad spectrum of scientific and industrial applications. The inherent complexity of enzymes, such as their substrate specificity, conformational flexibility, and the vast diversity of reactions involved, poses substantial challenges for the advanced computational prediction…

Bioresour Technol. 2026 Jul 14:135414. doi: 10.1016/j.biortech.2026.135414. Online ahead of print. ABSTRACT Terpenoids are valuable resources for pharmaceutical research, yet their natural supply remains constrained. While the artificial isoprenol utilization pathway (IUP) has emerged as a promising alternative for terpene precursor supply, its full potential is limited by suboptimal pathway flux and substrate tolerance. Here,…

Bioresour Technol. 2026 Jul 14:135368. doi: 10.1016/j.biortech.2026.135368. Online ahead of print. ABSTRACT Formate is emerging as a relevant intermediate in carbon capture and utilization technologies. However, its low energy density limits its value as an energy carrier. Some hydrogenotrophic methanogens can reduce formate to the established energy carrier methane. The stoichiometric limitation of formate disproportionation…

J Agric Food Chem. 2026 Jul 14. doi: 10.1021/acs.jafc.5c13382. Online ahead of print. ABSTRACT 4-Ethylphenol (4-EP) is an important aromatic fine chemical used as a flavor compound and as an intermediate in the synthesis of polymers and pharmaceuticals. Although 4-EP occurs naturally, the decarboxylase responsible for its formation from phloretic acid has not yet been…

Beilstein J Org Chem. 2026 Jul 10;22:1048-1056. doi: 10.3762/bjoc.22.83. eCollection 2026. ABSTRACT Dithiocarbamates are widely recognized for their versatile applications in both agriculture as effective pesticides and medicine, where they serve as antifungal and anticancer agents. As a result, their synthesis has garnered significant attention in recent years. In this study, we present an efficient…

Biomed Khim. 2026 Jul;72(3):188-197. doi: 10.18097/PBMCR1698. ABSTRACT Using atomic force microscopy (AFM), the heights of individual horseradish peroxidase (HRP) molecules were determined at different stages of the catalytic cycle of this enzyme (I-IV). The HRP heights were determined in two buffer systems: Dulbecco’s phosphate-buffered saline (PBSD) (pH 7.2) and citrate-phosphate buffer (CPB) (pH 5.0). Spectrophotometric…

Int J Biol Macromol. 2026 Jul 13:153472. doi: 10.1016/j.ijbiomac.2026.153472. Online ahead of print. ABSTRACT Engineering catalytic microenvironments within hybrid materials is a critical strategy for enhancing enzyme stability and catalytic efficiency; however, precise regulation of intermediate transfer and interfacial catalytic coupling remains challenging. Here, we report a crosslinking-regulated, double-crystallized hierarchical hybrid nanoflower system (D-Cu@c-GOx NFs)…