BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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ACS Synth Biol. 2026 Jul 13. doi: 10.1021/acssynbio.6c00218. Online ahead of print. ABSTRACT The search for more sustainable catalytic methods, such as biocatalysis and photocatalysis, has greatly contributed to a sustainable future of synthetic chemistry. Within photocatalysis, flavin-type heterocycles are powerful tools for oxidative transformations but often suffer from poor water solubility, photostability, and limited…
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J Biol Chem. 2026 Jul 13:113329. doi: 10.1016/j.jbc.2026.113329. Online ahead of print. ABSTRACT N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase (NAGPA), also known as the uncovering enzyme, catalyzes the final step in mannose-6-phosphate (M6P) signal generation for lysosomal enzyme trafficking. Despite its central role, the enzyme’s architecture, catalytic mechanism, and the contribution of its C-terminal region remain incompletely defined. Here,…
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J Biol Chem. 2026 Jul 13:113331. doi: 10.1016/j.jbc.2026.113331. Online ahead of print. ABSTRACT The increase in flooding events due to climate change is having devastating effects on food security. Plants can respond to submergence by reducing their energy requirements and switching their metabolism from oxidative phosphorylation to fermentation. This response is promoted by group VII…
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Nanomaterials (Basel). 2026 Jul 4;16(13):823. doi: 10.3390/nano16130823. ABSTRACT This work reports the development of innovative enzyme-titanium nanobiohybrids synthesized via a protein-assisted approach to obtain efficient and sustainable photocatalysts for environmental remediation. By addressing the limitations of conventional TiO2 nanoparticle synthesis, this strategy enables controlled material properties under milder, potentially scalable conditions for enhanced ROS-driven degradation…
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J Am Chem Soc. 2026 Jul 13. doi: 10.1021/jacs.6c11300. Online ahead of print. ABSTRACT Chiral organochlorides bearing C-Cl stereocenters are highly desirable motifs in synthetic and medicinal chemistry, yet their direct asymmetric synthesis from simple starting materials via biocatalysis alone remains challenging. Here, we report an integrated organo- and biocatalytic cascade that converts readily available…
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Acc Chem Res. 2026 Jul 13. doi: 10.1021/acs.accounts.6c00370. Online ahead of print. ABSTRACT ConspectusThiamine diphosphate (ThDP)-dependent enzymes are among nature’s most elegant biocatalysts for C-C bond formation and cleavage, typically operating through a two-electron umpolung mechanism. Although a small subset of ThDP enzymes, such as pyruvate: ferredoxin oxidoreductase (PFOR), has been shown to proceed via…
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Plant Cell Environ. 2026 Jul 13. doi: 10.1111/pce.70743. Online ahead of print. ABSTRACT Cuticular waxes, together with cutin, form a hydrophobic barrier that protects the plants against various biotic and abiotic stresses. The past decade has seen remarkable progress in deciphering the wax biosynthesis and transport, however, the continuous discovery of wax-defective mutants and the…
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Angew Chem Int Ed Engl. 2026 Jul 13:e2903805. doi: 10.1002/anie.2903805. Online ahead of print. ABSTRACT A covalent catch-and-release approach is described for the chemoenzymatic synthesis of HS oligosaccharides. It exploits that a glycan modified by a hydrazide tag can under mild acidic conditions efficiently be reacted with an aldehyde-containing resin to give an immobilized hydrazone…
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Angew Chem Int Ed Engl. 2026 Jul 13:e4872790. doi: 10.1002/anie.4872790. Online ahead of print. ABSTRACT A chemoenzymatic strategy is described as a method that can readily provide well-defined α(2,8)- and α(2,9)-linked oligosialic acids of different lengths. It employs the recombinant bacterial sialic acid polymerases, NmC-PST and NmB-PST, in combination with cytidine 5′-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac)…
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Arch Pharm (Weinheim). 2026 Jul;359(7):e70304. doi: 10.1002/ardp.70304. ABSTRACT Many naturally occurring substances exhibit anti-ulcer properties. One promising area of research is the identification of terpenoid compounds with enhanced therapeutic and gastroprotective properties. The present study aimed to synthesize new terpenoid derivatives of myrtenol via biotransformation using freeze-dried Cladosporium cladosporioides mycelium or via porphyrin-based biomimetic transformation,…