Arch Pharm (Weinheim). 2026 Jul;359(7):e70304. doi: 10.1002/ardp.70304. ABSTRACT Many naturally occurring substances exhibit anti-ulcer properties. One promising area of research is the identification of terpenoid compounds with enhanced therapeutic and gastroprotective properties. The present study aimed to synthesize new terpenoid derivatives of myrtenol via biotransformation using freeze-dried Cladosporium cladosporioides mycelium or via porphyrin-based biomimetic transformation,…

Protein Sci. 2026 Aug;35(8):e70692. doi: 10.1002/pro.70692. ABSTRACT Phenolic acid decarboxylases (PADs) convert bio-based hydroxycinnamic acids into valuable hydroxystyrene monomers under mild reaction conditions. These compounds are in high demand in polymer production, cosmetics, and flavoring. Especially 4-vinyl syringol, the decarboxylation product from sinapic acid, generates polymers with similar thermal stability and higher glass transition temperatures…

Chem Commun (Camb). 2026 Jul 12. doi: 10.1039/d6cc02702d. Online ahead of print. ABSTRACT Steroid synthesis is a cornerstone of pharmaceutical development, yet it remains hampered by the structural complexity of highly oxidized scaffolds and the presence of multiple stereogenic centers. Biocatalysis, characterized by unparalleled chemo-, regio-, and stereoselectivity, provides a sustainable and high-precision alternative for…

Org Lett. 2026 Jul 11. doi: 10.1021/acs.orglett.6c02434. Online ahead of print. ABSTRACT The development of efficient and highly diastereoselective methods for the synthesis of C-aryl glycosides remains an important objective in carbohydrate and medicinal chemistry. Here, we report an iron-catalyzed reductive cross-electrophile coupling of glycosyl chlorides with aryl iodides using hydrosilanes as reductants, which provides…

Angew Chem Int Ed Engl. 2026 Jul 11:e4567477. doi: 10.1002/anie.4567477. Online ahead of print. ABSTRACT Achieving selective oxygenation chemistry offers a powerful strategy for streamlining routes to complex target molecules, yet the development of site-selective C-H functionalization reactions is challenging. Several enzyme families are capable of catalyzing C-H hydroxylation reactions and, in principle, provide an…

Synth Syst Biotechnol. 2026 Jul 2;15:170-180. doi: 10.1016/j.synbio.2026.06.003. eCollection 2027 Jan. ABSTRACT Enzymatic depolymerization of polyethylene terephthalate (PET) offers a promising route to mitigate the increasingly severe problem of plastic pollution. However, the development of highly efficient PET hydrolases capable of processing post-consumer PET remains a critical challenge. Recent advances in artificial intelligence (AI) provide…

ACS Mater Au. 2026 Jun 12;6(4):841-850. doi: 10.1021/acsmaterialsau.6c00039. eCollection 2026 Jul 8. ABSTRACT Enzyme immobilization on solid supports enhances stability and reusability, yet nanoscale carriers such as metal-organic frameworks (MOFs) still face challenges in efficient recovery. While pyrolysis can magnetize Fe-MOFs, conventional methods often compromise either enzyme activity or structural integrity. This study presents a…