J Hazard Mater. 2026 Jul 10;515:142972. doi: 10.1016/j.jhazmat.2026.142972. Online ahead of print. ABSTRACT The development of multifunctional photocatalysts capable of simultaneously eliminating biological and chemical pollutants is of critical importance for indoor environmental remediation. Herein, a tightly coupled UiO-66-NH2/Mn3O4 heterojunction was rationally constructed via an in-situ growth followed by an annealing strategy. The formation of…

J Am Chem Soc. 2026 Jul 15. doi: 10.1021/jacs.6c08412. Online ahead of print. ABSTRACT Metal-organic frameworks (MOFs) are promising platforms for biomolecular applications due to their tunable structures, high surface areas, and catalytic functionality. Zr-based MOFs, in particular, exhibit protease-like activity; however, the interfacial factors governing protein adsorption onto MOF materials and their impact on…

Angew Chem Int Ed Engl. 2026 Jul 15:e3307774. doi: 10.1002/anie.3307774. Online ahead of print. ABSTRACT Tertiary amines are privileged motifs in bioactive molecules. However, their chemical synthesis lacks sustainability, and biocatalytic alternatives remain underdeveloped. Therefore, there is an urgent need to develop innovative catalytic strategies. We herein disclose the engineering of a wild-type imine reductase…

Int J Mol Sci. 2026 Jun 24;27(13):5695. doi: 10.3390/ijms27135695. ABSTRACT The efficacy of enzyme therapy is limited by their poor stability under physiological conditions. Thermostable enzymes, derived from extremophilic organisms or generated by advanced protein engineering, offer a revolutionary solution to this long-standing challenge. They are widely used in industrial biocatalysis. Their therapeutic applications are…

Int J Mol Sci. 2026 Jul 3;27(13):5982. doi: 10.3390/ijms27135982. ABSTRACT Tretinoin (all-trans-retinoic acid, ATRA) is an established therapy for acute promyelocytic leukemia (APL) and neuroblastoma (NB); however, its broader oncological application is limited by poor bioavailability and rapid resistance development. In this study, we developed lipidic ester derivatives of ATRA as a potential prodrug approach…

Molecules. 2026 Jun 24;31(13):2226. doi: 10.3390/molecules31132226. ABSTRACT Ionic liquids remain attractive alternatives as multifunctional media for the sustainable biosynthesis of lactones. Their unique physicochemical properties, including negligible vapor pressure, high thermal stability, and tunable polarity, offer significant advantages in terms of biocatalyst stabilization and reaction selectivity. For lactone synthesis, ionic liquids facilitate improved control over…

Molecules. 2026 Jun 24;31(13):2230. doi: 10.3390/molecules31132230. ABSTRACT The rapid expansion of high-protein dairy-based powders (HPDPs), including milk protein concentrates and isolates (MPC/MPI), whey protein concentrates and isolates (WPC/WPI), and micellar casein concentrates and isolates (MCC/MCI), has intensified the need to understand instability phenomena that emerge during processing and storage. These products are governed by protein-rich…

Molecules. 2026 Jul 3;31(13):2344. doi: 10.3390/molecules31132344. ABSTRACT Enzymatic nanomotors (EMNMs) represent an emerging class of intelligent nanosystems that exploit enzymatic biocatalysis to generate autonomous motion within biological environments, including complex cellular and tissue contexts within living organisms. Owing to their ability to utilize endogenous biofuels, high biocompatibility, and capacity for targeted propulsion, EMNMs have demonstrated…

Molecules. 2026 Jul 4;31(13):2359. doi: 10.3390/molecules31132359. ABSTRACT The combination of computational and experimental methods has become indispensable for optimization and rational enzyme design. Recently, the development of artificial intelligence (AI)-based tools has further streamlined enzyme engineering pipelines, enabling more accurate designs, while reducing the number of variants required for experimental validation. However, due to the…

Biotechnol Prog. 2026 Jul 14:e88535. doi: 10.1002/btpr.88535. Online ahead of print. ABSTRACT The sustainable production of hydroxy fatty acids, such as 10-hydroxystearic acid (10-HSA), by biocatalysis is a promising alternative to petrochemical and castor oil-derived products. However, industrial implementation still requires an efficient and scalable process for biocatalyst production by fermentation, which precedes the biotransformation…