BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
-
Curr Top Med Chem. 2026 Jul 14. doi: 10.2174/0115680266461232260515094327. Online ahead of print. ABSTRACT Ganoderma lucidum fermentation (GLF) serves as a sustainable biotransformation platform that precisely modulates the chemical profiles and bioactivities of natural products through enzymatic hydrolysis, microbial metabolic remodeling, and substrate-microbe crosstalk. This review systematically elucidates the GLF-driven structural modifications of key compounds-…
-
Crit Rev Biotechnol. 2026 Jul 21:1-19. doi: 10.1080/07388551.2026.2691230. Online ahead of print. ABSTRACT Steroids represent a cornerstone of modern pharmacotherapy, with their physiological functions intrinsically linked to precise hydroxylation patterns on the steroid nucleus. Hydroxylation of inert C-H bonds on the steroid nucleus is critical for their physiological and pharmacological activities. However, conventional chemical hydroxylation…
-
Chem Commun (Camb). 2026 Jul 22. doi: 10.1039/d6cc03013k. Online ahead of print. ABSTRACT We develop a metal-organic-framework-derived heterostructure as a high-performance sodium-ion battery anode. The Co9S8@NiFeS2 anode displays a capacity of 429.2 mAh g-1 after 1500 cycles at 1 A g-1 with a good retention rate, and retains 331.3 mAh g-1 after 3100 cycles at…
-
Biotechnol Bioeng. 2026 Jul 21. doi: 10.1002/bit.70320. Online ahead of print. ABSTRACT Aromatic lactones, including Homogentisate-γ-lactone, 2-coumaronone, and coumarin, have broad applications in pharmaceuticals and agrochemicals, due to their antimicrobial, anti-inflammatory, and antioxidant activities. However, their industrial production relies on multistep chemical synthesis or plant extraction, which suffer from harsh reaction conditions, low efficiency, and…
-
J Biol Eng. 2026 Jul 20. doi: 10.1186/s13036-026-00729-7. Online ahead of print. ABSTRACT Alkaloid N-demethylation is a critical step in the production of many semi-synthetic alkaloid therapeutics and has traditionally relied on synthetic chemical routes. Microbial whole-cell bioproduction offers a promising alternate route for generating these valuable pharmaceuticals. This work demonstrated a greener N-demethylation platform…
-
ChemSusChem. 2026 Jul 29;19(14):e70889. doi: 10.1002/cssc.70889. ABSTRACT Chemoselective reduction of stable carboxylic acids to reactive aldehydes is of interest across many industries. While carboxylic acid reductases (CARs) are promising biocatalysts for this chemistry, poor chemoselectivity and low yield are commonly obtained when using less expensive crude lysate preparations and prerequisite ATP and NADPH regeneration systems.…
-
Nucleic Acids Res. 2026 Jul 17;54(14):gkag724. doi: 10.1093/nar/gkag724. ABSTRACT RNA interference (RNAi) in nematodes is amplified through the generation of secondary small interferring RNA (siRNA) from products of primary siRNA cleavage. This process requires RDE-3, a unique ribonucleotidyltransferase that adds a poly(UG) tail of alternating U and G nucleotides without a template. Here we demonstrated…
-
Adv Sci (Weinh). 2026 Jul 20:e76698. doi: 10.1002/advs.76698. Online ahead of print. ABSTRACT Lignin, the largest renewable aromatic carbon reservoir, represents a foundational yet underutilized feedstock for sustainable biomanufacturing. Despite decades of effort, its effective integration remains constrained, not only by inefficient depolymerization but critically by the lack of coordinated control across depolymerization, conversion, and…
-
Org Biomol Chem. 2026 Jul 20. doi: 10.1039/d6ob00784h. Online ahead of print. ABSTRACT Cannabis sativa is a major source of phytocannabinoids, with cannabidiol (Δ9-CBD) serving as a key precursor to THC-type cannabinoids through acid-catalyzed intramolecular cyclization. However, the origin of regioselectivity under different conditions remains unclear. Herein, combined experimental and theoretical approaches were employed to…
-
Org Biomol Chem. 2026 Jul 20. doi: 10.1039/d6ob00796a. Online ahead of print. ABSTRACT A highly efficient and enantioselective bioreduction of 4-phenyl-6,7-dihydrothieno[3,2-c]pyridine has been developed, marking the first successful access to its optically pure (R)-tetrahydrothienopyridine derivative. Given that (R)-enantiomers in this class exhibit superior antibacterial activity compared to their (S)-counterparts, providing a scalable route to these…