BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Adv Healthc Mater. 2026 Jul 19:e71448. doi: 10.1002/adhm.71448. Online ahead of print. ABSTRACT Oral diseases represent a major global health burden, underscoring the need for sensitive, accessible, and noninvasive diagnostic technologies. Electrochemical biosensing offers a powerful route for point-of-care oral health monitoring by translating biomolecular interactions in saliva, gingival crevicular fluid, and exhaled breath condensate…
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Nat Commun. 2026 Jul 18. doi: 10.1038/s41467-026-75664-8. Online ahead of print. ABSTRACT The biocatalytic conversion of green methanol, a promising feedstock, into high value-added products is seen as an attractive way to establish sustainable biomanufacturing. Although natural and engineered microorganisms can utilize methanol, efficiently converting C1 carbon into valuable chemicals in growing cells remains challenging…
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Langmuir. 2026 Jul 18. doi: 10.1021/acs.langmuir.6c01553. Online ahead of print. ABSTRACT A hierarchical magnetic core-shell gel platform was developed for lipase immobilization to achieve enhanced catalytic performance. The architecture integrates an Fe3O4 magnetic core, a multiamine-functionalized silica shell for covalent lipase attachment via glutaraldehyde cross-linking, and a hydrophilic calcium alginate (CaAlg) gel encapsulation layer. This…
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Sci China Life Sci. 2026 Jul 16. doi: 10.1007/s11427-025-3307-6. Online ahead of print. ABSTRACT This study aims to provide a comprehensive understanding of the magnitude and trends of cancer burden caused by various risk factors, in order to inform global cancer control strategies and interventions. We estimated age-standardized death rates (ASDR), age-standardized disability-adjusted life years…
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STAR Protoc. 2026 Jul 17;7(3):104706. doi: 10.1016/j.xpro.2026.104706. Online ahead of print. ABSTRACT Here, we present a protocol for generating high-throughput, droplet-engineered tumor organoids from triple-negative breast cancer (TNBC) tissues using the OrgFab® micro-sphere printing system. We describe tumor dissociation, bioink preparation, and automated organoid fabrication. We further detail rho-associated coiled-coil kinase (ROCK) pathway modulation to…
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J Exp Bot. 2026 Jul 16:erag350. doi: 10.1093/jxb/erag350. Online ahead of print. ABSTRACT Flavonoids, a class of phenolic compounds widely distributed throughout the plant kingdom, exhibit extensive physiological and pharmacological properties. Chalcone synthase (CHS), the key and rate-limiting gateway enzyme in flavonoid biosynthesis, catalyzes the condensation reaction between malonyl-CoA and p-coumaroyl-CoA to produce chalcone, the…
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J Am Chem Soc. 2026 Jul 17. doi: 10.1021/jacs.6c06323. Online ahead of print. ABSTRACT Developing enzymatic mechanisms for C-F bond formation remains a long-standing challenge. Here, we repurposed the biosynthetic nonheme Fe enzyme EgtB, which features a three-histidine facial triad, to catalyze C(sp3)-H fluorination reactions. Directed evolution of EgtB afforded two new-to-nature fluorine atom transferases…
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Sci Rep. 2026 Jul 17;16(1):22513. doi: 10.1038/s41598-026-61978-6. ABSTRACT Copper-based nanozymes are increasingly used as artificial laccases, yet most rely on simple catechol ligands such as dopamine or gallic acid which provide limited control over metal coordination geometry and stability. In this work, we introduce methyldopa as a biomimetic bidentate ligand whose dual catechol-amine functionality closely…
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Sci China Life Sci. 2026 Jul 15. doi: 10.1007/s11427-026-3397-y. Online ahead of print. ABSTRACT Liquid-liquid phase separation (LLPS)-mediated formation of membraneless, biomolecule-rich organelles formed via LLPS is critical to numerous biological processes, but how this spatiotemporal control enables efficient catalysis by biosynthetic enzymes to produce natural products (NPs) remains poorly understood. Here, we demonstrate that…
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Bioresour Technol. 2026 Jul 17:135433. doi: 10.1016/j.biortech.2026.135433. Online ahead of print. ABSTRACT Diguanylate cyclase (DGC) synthesizes c-di-GMP, an important second messenger that regulates exopolysaccharide production in many bacteria. WL gum is a commercially important exopolysaccharide produced by Sphingomonas sp. WG, however, the DGCs that modulate its biosynthesis remain unidentified. The function of Dgc1 was investigated…