Adv Mater. 2026 Jul 25:e74304. doi: 10.1002/adma.74304. Online ahead of print. ABSTRACT Bacterial infection poses a significant threat to clinical treatment due to the emergence of drug resistance and the high risk of recurrence. Here, we report the de novo design of a spiky pollen-based vanadium artificial enzyme particle (VAE-Pollen) that integrates potent reactive oxygen…

ChemSusChem. 2026 Aug 14;19(15):e70914. doi: 10.1002/cssc.70914. ABSTRACT Multienzyme cascades are emerging as alternatives to fermentation for converting biogenic feedstocks into value-added chemicals and fuels. A major bottleneck in redox transformations is the loss of costly and unstable cofactors in continuous-flow systems, typically necessitating co-immobilization and complex regeneration schemes. Self-sufficient biocatalytic nanomachines, created by fusing enzymes…

ChemSusChem. 2026 Aug 14;19(15):e70915. doi: 10.1002/cssc.70915. ABSTRACT 2,5-Bis(hydroxymethyl)furan (BHMF) is a useful intermediate for manufacturing biobased polymers, biofuels, and fine chemicals. Biocatalytic reduction of 5-hydroxymethylfurfural (HMF) obtained via hexoses dehydration is a sustainable route toward BHMF, but the demand for efficient and cost-effective processes remains highly pressing. In this work, cofactor specificity engineering of an…

ACS Cent Sci. 2026 Jun 29;12(7):1029-1037. doi: 10.1021/acscentsci.6c00531. eCollection 2026 Jul 22. ABSTRACT Access to noncanonical amino acids is increasingly important in natural products synthesis and drug discovery. Enzymatic synthesis has emerged as an efficient strategy for simplifying approaches toward these molecules. Pyridoxal-5′-phosphate (PLP)-dependent enzymes have been extensively studied for the biocatalytic functionalization of α-amino…

J Mol Biol. 2026 Jul 24:169958. doi: 10.1016/j.jmb.2026.169958. Online ahead of print. ABSTRACT Metals are frequently exploited in the active sites of enzymes; however, the involvement of rare earth elements (REEs) in biocatalysis has been less commonly observed. Here, we show that the alcohol dehydrogenase D (AdhD) from Pyrococcus furiosus can bind REE ions, and…

ChemMedChem. 2026 Jul 29;21(14):e70395. doi: 10.1002/cmdc.70395. ABSTRACT A biocatalytic approach was applied to synthesizing esters and amides derived from 2-(1H-indol-3-yl)acetic (IAA), 3-(1H-indol-3-yl)propionic (IPA), and 4-(1H-indol-3-yl)butanoic (IBA) acids. Thirty-seven derivatives were obtained through lipase catalysis in mild reaction conditions with good to excellent yields and a reduced environmental impact. The scope of the reaction was explored…

Prep Biochem Biotechnol. 2026 Jul 24:1-15. doi: 10.1080/10826068.2026.2705568. Online ahead of print. ABSTRACT Lipases obtained from thermophilic microorganisms are attracting great interest in the industrial field due to their stability under high-temperature conditions and their wide range of industrial applications. In this study, thermophilic bacterial strains were isolated from water and mud samples collected from…

Sci Adv. 2026 Jul 24;12(30):eaeg3025. doi: 10.1126/sciadv.aeg3025. Epub 2026 Jul 24. ABSTRACT Atropisomeric compounds are widely distributed in natural products and pharmaceuticals and serve as key scaffolds in asymmetric catalysis. Despite their remarkable structural diversity, current synthetic efforts have primarily focused on C-C biaryl atropisomers, while the synthesis of other classes of atropisomeric compounds has…

Chembiochem. 2026 Jul 29;27(14):e70474. doi: 10.1002/cbic.70474. ABSTRACT Efficient, selective, and sustainable synthetic platforms are increasingly important in modern chemical manufacturing, yet chemical flexibility often remains limited. In this study, we develop a modular biocatalytic system for the divergent and continuous transformation of ethyl acetoacetate (EAA) into either enantiomerically pure (R)-3-hydroxybutyric acid ((R)-3HBA) or oligomers of…