Angew Chem Int Ed Engl. 2026 Aug 22:e7251439. doi: 10.1002/anie.7251439. Online ahead of print. ABSTRACT The cooperative integration of photoredox catalysis and metalloenzyme catalysis has emerged as a powerful strategy for enabling stereoselective radical transformations beyond the capabilities of either catalytic mode alone. Herein, we report a photometallobiocatalytic enantioselective intermolecular C─C cross-coupling of pyridotriazoles and…

Nat Catal. 2026;9(8):882-892. doi: 10.1038/s41929-026-01587-8. Epub 2026 Jul 31. ABSTRACT Developing enzymatic strategies to selectively construct C-C and C-heteroatom bonds is a major objective in modern biocatalysis. Here we combine genetic code reprogramming and laboratory evolution to establish a family of allylic transferase enzymes that can achieve a remarkable breadth of chemistry, enabling the generation…

Nat Catal. 2026;9(8):834-847. doi: 10.1038/s41929-026-01576-x. Epub 2026 Jul 17. ABSTRACT DNA-encoded chemical library (DEL) technology is a powerful tool in early-stage drug discovery. Although widely applied in industry and academia, challenges persist in generating DELs with high quality and chemical diversity. Low yields in building-block incorporation, limited selectivity and, most importantly, DNA damage from harsh…

Chin J Nat Med. 2026 Sep;24(9):1110-1122. doi: 10.1016/S1875-5364(26)61207-1. ABSTRACT Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of taladipyrones A-I (1-9), a series of new α-pyrone dimers with four distinct skeletons. Among these, compounds 1 and 9 represented…

Curr Opin Chem Biol. 2026 Aug 21;94:102751. doi: 10.1016/j.cbpa.2026.102751. Online ahead of print. ABSTRACT The application repertoire of industrial biotechnology is constrained by the reaction scope of natural biocatalysis, which covers only a fraction of the accessible chemical space. To expand the versatility of biomanufacturing, abiological organometallic catalysts can be integrated into synthetic biology in…

Bioprocess Biosyst Eng. 2026 Aug 21. doi: 10.1007/s00449-026-03407-6. Online ahead of print. ABSTRACT Omega-3 polyunsaturated fatty acids (n-3 PUFAs) offer therapeutic benefits, including triglyceride reduction and management of cardiovascular and neurological disorders. This study investigates the use of fish oil processing by‑products, which consist mainly of fatty acid methyl and ethyl esters, as novel substrates…

Chembiochem. 2026 Aug 27;27(16):e70511. doi: 10.1002/cbic.70511. ABSTRACT ω-Hydroxy and oxo acids are versatile platform chemicals, accessible via enzymes of the iron-containing alcohol dehydrogenase (FeADH) superfamily. Compared with well-characterized zinc-dependent ADHs, FeADHs producing such compounds remain poorly defined regarding assignment to genetic locus, biochemical and biophysical properties, and metal specificity. Here, we uncover two FeADHs from…

Enzyme Microb Technol. 2026 Aug 17;201:110958. doi: 10.1016/j.enzmictec.2026.110958. Online ahead of print. ABSTRACT Glucose dehydrogenase (GDH) is a key enzyme for NAD(P)H cofactor regeneration in industrial biocatalysis. However, conventional engineering approaches are frequently constrained by limited catalytic efficiency and excessive enzyme loading, which collectively compromise process economics and hinder large-scale deployment. In this study, we…

Adv Mater. 2026 Aug 21:e74601. doi: 10.1002/adma.74601. Online ahead of print. ABSTRACT The escalating prevalence of multidrug-resistant bacterial infections presents a grave global health challenge, highlighting the limitations of traditional antibacterial materials that rely on passive release mechanisms. This paper comprehensively reviews the emerging frontier of stimuli-responsive smart antibacterial fibers (SAFs), which embody a paradigm…