Molecules. 2026 Aug 14;31(16):2839. doi: 10.3390/molecules31162839. ABSTRACT The electrochemical sensing of similar catecholamines remains challenging due to their overlapping redox behavior and similar reactivity, which often results in poorly selective reaction pathways. Herein, we report a bioinspired tyrosinase electro-catalytic system that enables the modulation of the catecholamine reactivity through the integration of enzymatic oxidation with…

Org Process Res Dev. 2026 Jul 22;30(8):2159-2166. doi: 10.1021/acs.oprd.6c00056. eCollection 2026 Aug 21. ABSTRACT We describe a scalable aryl alcohol oxidase-based alcohol oxidation platform using multiphase and microaqueous reaction formats. Using trans-2-hexen-1-ol as a model substrate, a 9:1 n-dodecane/buffer two-liquid-phase system (100 mL, 0.55 M substrate) delivered up to ∼0.42 M trans-2-hexen-1-al with initial space-time…

Bioresour Technol. 2026 Aug 25:135726. doi: 10.1016/j.biortech.2026.135726. Online ahead of print. ABSTRACT The adjustment of the surface chemistry of lignin nanoparticles (LNPs) can be effectively achieved through laccase-induced biocatalysis. However, the mechanistic and fractional aspects of this process remain largely unknown. This study investigated the reaction mechanisms induced by recombinant Coprinopsis cinereus laccase (CcLcc9) in…

Angew Chem Int Ed Engl. 2026 Aug 24:e6230875. doi: 10.1002/anie.6230875. Online ahead of print. ABSTRACT We herein describe a biocatalytic halogenation approach that harnesses the reverse dehalogenation reaction of halohydrin dehalogenases. Through the integration of enzyme screening and structure-guided protein engineering, a double mutant of HheC (T134S/W139M) was created for the enantioselective halogenation of spiro-epoxyoxindoles,…

Org Biomol Chem. 2026 Aug 25. doi: 10.1039/d6ob00991c. Online ahead of print. ABSTRACT Over the past several decades, biocatalysis has become a valuable complement to synthetic chemistry due to its high efficiency, exceptional selectivity, and environmental compatibility. Thiamine diphosphate (ThDP), the biologically active form of vitamin B1, serves as an essential coenzyme for core metabolic…

Circulation. 2026 Aug 25. doi: 10.1161/CIRCULATIONAHA.125.079049. Online ahead of print. ABSTRACT BACKGROUND: Myocardial infarction can cause a massive loss of functional cardiomyocytes, yet effective strategies to stimulate cardiac regeneration remain lacking. A key barrier to adult cardiomyocyte proliferation appears to be cytokinesis inhibition. This study aimed to determine whether combining proliferation stimulators with the removal…

Biotechnol Adv. 2026 Aug 23:109024. doi: 10.1016/j.biotechadv.2026.109024. Online ahead of print. ABSTRACT Artificial enzymes represent transformative biocatalysts that overcome the inherent limitations of natural enzymes in substrate scope and activity specificity, enabling challenging new-to-nature reactions. Despite remarkable advances in designing diverse artificial enzymes through synthetic cofactor or non-canonical amino acid incorporation, their widespread industrial application…

Food Chem X. 2026 Aug 11;38:104302. doi: 10.1016/j.fochx.2026.104302. eCollection 2026 Aug. ABSTRACT Epilactose is a promising functional disaccharide, but its biomanufacturing is limited by insufficient enzyme activity, poor thermostability, and costly catalyst preparation. We first used the REME platform to computationally evaluate candidate enzymes. Among them, cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus (CsCE) showed the highest…