Trends Biotechnol. 2026 Sep 19:S0167-7799(26)00377-X. doi: 10.1016/j.tibtech.2026.09.007. Online ahead of print.

ABSTRACT

When replacing expensive redox cofactors, making biomimetic cofactors with desirable thermostability and redox properties is only half of the equation; enzymes must also be able to use them. Ji and colleagues confront that trade-off by pairing the development of a thermostable carbocyclic cofactor with a dedicated regeneration enzyme for sustained biocatalysis.

PMID:42763265 | DOI:10.1016/j.tibtech.2026.09.007