BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Chembiochem. 2026 Apr 14;27(7):e70297. doi: 10.1002/cbic.70297. ABSTRACT Microviridins are a prominent family of highly potent serine protease inhibitors, of which individual variants specifically inhibit different types of proteases of pharmacological interest. These natural products of cyanobacterial origin belong to the ribosomally synthesized and posttranslationally modified peptides and feature an unusual cage-like architecture, which is composed…
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Compr Rev Food Sci Food Saf. 2026 May;25(3):e70449. doi: 10.1111/1541-4337.70449. ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant-based proteins is a promising route, but it also comes with challenges: Plant-based proteins often contain antinutritional…
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J Am Chem Soc. 2026 Mar 31. doi: 10.1021/jacs.6c01122. Online ahead of print. ABSTRACT Metal-support interfaces serve as the key active sites for catalytic reactions. The design of catalysts that simultaneously possess high interfacial density, superior activity, and robust stability represents a central challenge in enhancing the overall performance. Herein, we report an innovative synchronic…
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J Agric Food Chem. 2026 Mar 31. doi: 10.1021/acs.jafc.5c17527. Online ahead of print. ABSTRACT Chenodeoxycholic acid, a precursor to ursodeoxycholic acid, can be synthesized from inexpensive cholic acid through a two-step chemoenzymatic route. Here, a dual flow reactor system was developed to intensify this process. First, a packed-bed reactor with coimmobilized enzymes achieved complete conversion…
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Inorg Chem. 2026 Mar 27. doi: 10.1021/acs.inorgchem.5c05807. Online ahead of print. ABSTRACT Supramolecular host-guest systems have long served as models for understanding receptor-substrate interactions and enzyme-like behavior. In fact, they can also serve as a powerful tool to study competition for substrates in a crowded cellular milieu, where many distinct proteins can bind the same…
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Arch Orthop Trauma Surg. 2026 Mar 28;146(1):127. doi: 10.1007/s00402-026-06278-4. ABSTRACT INTRODUCTION: The purpose of this study was to perform biomechanical pull-out comparisons between composite bone blocks and additively manufactured bone models using locked plate and screw systems. The hypothesis posited that the mean pull-out force of the 3D-printed models would demonstrate non-inferior pull-out strength compared…
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Angew Chem Int Ed Engl. 2026 Mar 19:e00006. doi: 10.1002/anie.202600006. Online ahead of print. ABSTRACT We describe a photoenzymatic hydroalkylation reaction that enables the efficient and stereocontrolled synthesis of aryl glutarimide precursors-chemically and configurationally robust entry points to bioactive agents for targeted protein degradation. Screening of flavin-dependent “ene”-reductases identified GluER HArac, a G. oxydans variant,…
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J Photochem Photobiol B. 2026 Mar 18;278:113428. doi: 10.1016/j.jphotobiol.2026.113428. Online ahead of print. ABSTRACT A green sol-gel method was utilized to produce a Zr-decorated TiO₂ nanocomposite exhibiting improved photocatalytic and biological activity under visible light irradiation. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) provided structural and morphological characterisation, confirming the…
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Bioelectrochemistry. 2026 Mar 20;171:109284. doi: 10.1016/j.bioelechem.2026.109284. Online ahead of print. ABSTRACT Fossil fuels are a finite and polluting source of energy. As global energy consumption rises alongside greenhouse gas emissions, future alternatives are needed. Renewable fuels present a promising alternative but require coupling the fuel synthesis with another process to achieve economic viability. Methods for…
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Talanta. 2026 Feb 28;305:129602. doi: 10.1016/j.talanta.2026.129602. Online ahead of print. ABSTRACT While the precise identification of cancer cells holds significant importance for early diagnosis, prediction of prognosis in patients and evaluating the risk of recurrence after surgery, the intracellular imaging of low abundance of miRNA biomarkers is essential for recognizing tumor cells but remains highly…