RSC Adv. 2026 May 6;16(26):23613-23624. doi: 10.1039/d6ra01830k. eCollection 2026 May 5. ABSTRACT Enzyme immobilization is central to advancing sustainable biocatalysis, yet conventional supports often fail to simultaneously provide structural protection, mass transport, and chemical tunability. Traditional support materials often lack the optimal combination of porosity, stability, and surface functionality needed to preserve enzyme activity. Metal-organic…

ACS Appl Mater Interfaces. 2026 May 8. doi: 10.1021/acsami.6c03433. Online ahead of print. ABSTRACT Effective management of infected wounds requires biomaterials that simultaneously combat infection, oxidative stress, and impaired healing. This study developed a green-synthesized multifunctional hydrogel (TP-Ag@BDH) by incorporating tea polyphenol (TP) and TP-capped silver nanoparticles (TP-AgNPs) into a BDDE-cross-linked matrix of deacetylated sphingan…

Science. 2026 May 7;392(6798):643-647. doi: 10.1126/science.aed8713. Epub 2026 May 7. ABSTRACT Historically, many compelling therapeutic targets have been accessible only by injectable biologic drugs. Macrocyclic peptides, such as the proprotein convertase subtilisin/kexin type 9 inhibitor enlicitide for the treatment of atherosclerotic cardiovascular disease, are beginning to unlock these targets to orally administered therapies to enable…

Proc Natl Acad Sci U S A. 2026 May 12;123(19):e2529856123. doi: 10.1073/pnas.2529856123. Epub 2026 May 7. ABSTRACT Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleotide (RNA) to deoxyribonucleotide (DNA) building blocks initiated by a long-range (>30 Å) proton-coupled electron transfer (PCET) by mechanistic principles that remain much debated. By combining multiscale quantum and classical simulations…

Angew Chem Int Ed Engl. 2026 May 7:e7226888. doi: 10.1002/anie.7226888. Online ahead of print. ABSTRACT The trifluoromethyl (CF3) group is a pivotal motif in pharmaceuticals, agrochemicals, and functional materials, yet achieving direct and regioselective aromatic C─H trifluoromethylation-especially for phenols and anilines-remains a formidable challenge. Here, we transform a dual-functional small molecule (DFSM)-facilitated P450BM3 peroxizyme into…

J Am Chem Soc. 2026 May 7. doi: 10.1021/jacs.6c05858. Online ahead of print. ABSTRACT Enzymatic depolymerization of polyethylene terephthalate (PET) is typically limited to the amorphous regions of the plastic, therefore requiring energy-intensive pretreatment. Here, using the commercial cutinase HiC, we demonstrate that mechanoenzymatic reactions under moist-solid conditions enable nearly complete depolymerization of highly crystalline…

Small. 2026 May 7:e73690. doi: 10.1002/smll.73690. Online ahead of print. ABSTRACT Cargo encapsulation offers broad opportunities in synthetic biology, biocatalysis, and therapeutic delivery, with encapsulins serving as nanoscale reaction chambers or protective carriers. Yet, controlling cargo loading remains challenging. Here, we reveal a molecular-scale understanding of gold nanoparticle encapsulation in encapsulin protein cages. Experiments investigate…

Bioorg Chem. 2026 Apr 22;178:109886. doi: 10.1016/j.bioorg.2026.109886. Online ahead of print. ABSTRACT Salicylate hydroxylase (NahG), a flavin-dependent monooxygenase, catalyzes the oxidative decarboxylation of salicylate via ipso-hydroxylation mediated by a C4a-hydroperoxyflavin intermediate. Here, we show that systematic variation of the carbonyl substituent in salicylate-derived substrates spanning amide, hydroxamic acid, ester, aldehyde, and ketone functionalities modulates catalytic…

J Chem Inf Model. 2026 May 6. doi: 10.1021/acs.jcim.6c01268. Online ahead of print. NO ABSTRACT PMID:42091242 | DOI:10.1021/acs.jcim.6c01268