Plant J. 2026 May;126(3):e70914. doi: 10.1111/tpj.70914. ABSTRACT Suberin is a biopolymer barrier mainly deposited on roots to protect plants against drought stress. Suberin monomers are composed of long-chain and very-long-chain fatty acids and their derived compounds. The mechanisms of suberin biosynthesis are well investigated in Arabidopsis, rice, and tomato. However, it remains unclear whether these…

Adv Healthc Mater. 2026 May 6:e03992. doi: 10.1002/adhm.202503992. Online ahead of print. ABSTRACT Adoptive T cell therapy holds great promise for the treatment of solid tumors but remains constrained by tumor heterogeneity, inefficient neoantigen targeting, and the complexity of T cell manufacturing. Here, we present a patient-specific, broadly applicable platform using physically inactivated tumor organoids…

Nat Commun. 2026 May 5;17(1):4071. doi: 10.1038/s41467-026-72558-7. ABSTRACT The fixation of dissolved inorganic carbon (DIC) such as CO2 and bicarbonate is fundamental to the global primary production. Many autotrophs depend on a diversity of CO2-concentrating mechanisms (CCMs) to overcome the inefficiency of ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and the limited supply of DIC. While cyanobacterial CCMs are…

Nat Prod Rep. 2026 May 5. doi: 10.1039/d6np00006a. Online ahead of print. ABSTRACT Covering: up to January 2026Methyltransferases (EC 2.1.1.-) represent one of the most functionally diverse enzyme families in biology. Found across all domains of life-including bacteria, archaea, eukaryotes, and viruses-these enzymes catalyze a wide range of methylation reactions, commonly on O-, N-, and…

Food Res Int. 2026 Jul 1;235:119177. doi: 10.1016/j.foodres.2026.119177. Epub 2026 Apr 15. ABSTRACT Metal-organic frameworks (MOFs) with tunable porosity are promising carriers for enzyme immobilization, but their practical application is limited by structural instability and difficult recovery. We previously developed an oxidation-reduction (O-R) pyrolysis strategy for mesoporous MIL-88 A, yielding a magnetic carrier (O-R-Meso) with…

Microb Biotechnol. 2026 May;19(5):e70369. doi: 10.1111/1751-7915.70369. ABSTRACT Cytochrome P450 monooxygenases (P450s) not only play many physiological roles in oxidative metabolism but are also promising biocatalysts for the synthesis of organic molecules. Bacillus subtilis strain 168, which possesses eight P450 genes, has been extensively studied as a model bacterium, but the catalytic function of CYP107J1 remains…

Acta Naturae. 2026 Jan-Mar;18(1):83-90. doi: 10.32607/actanaturae.27820. ABSTRACT Pyridoxal-5′-phosphate (PLP)-dependent transaminases are highly efficient biocatalysts for the stereoselective synthesis of chiral amines, which are key building blocks in pharmaceuticals and chemical manufacturing. Fundamental research on enzymatic transamination includes the classical works of Alexander Braunstein, who discovered the transamination reaction; David Metzler, who studied the spectral properties…

J Agric Food Chem. 2026 May 5. doi: 10.1021/acs.jafc.6c03303. Online ahead of print. ABSTRACT Fungal DMATS-type prenyltransferases catalyze the prenylation of diverse natural products, particularly indole derivatives, but also plant metabolites such as flavonoids. The prenyltransferase UcdE from Aspergillus ustus was previously suggested to catalyze ortho-prenylation of the p-terphenyl derivative dihydroxyterphenyllin. Biochemical investigations with recombinant…

J Chem Inf Model. 2026 May 4. doi: 10.1021/acs.jcim.6c00576. Online ahead of print. ABSTRACT Stereodivergence is an important method in biocatalysis to access all possible stereoisomers by performing minimal changes in the enzymatic system. However, the growth remains slow due to an incomplete understanding of the role of mutations. Herein, we utilize an array of…

Front Immunol. 2026 Apr 17;17:1812063. doi: 10.3389/fimmu.2026.1812063. eCollection 2026. ABSTRACT INTRODUCTION: CD28 is a critical co-stimulatory receptor expressed on T cells. Alongside the T-cell receptor (TCR), it provides a dual-signal requirement that is necessary for the complete activation of T cells. Developing co-stimulatory agonists targeting CD28 therefore represents a promising strategy to enhance the efficacy…