Biotechnol Bioeng. 2026 Jun 11. doi: 10.1002/bit.70270. Online ahead of print. ABSTRACT A recombinant whole-cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole-cell biocatalysis has gained attention in medicinal opioid production, due to its technical…

Small. 2026 Jun 11:e74144. doi: 10.1002/smll.74144. Online ahead of print. ABSTRACT Reoccluding the exposed dentinal tubules is crucial for treating dentin hypersensitivity (DH). However, the narrow structure and high-density negative charges of dentinal tubules impede the penetration of filling repair materials to effectively achieve deep-induced mineralization for DH treatment. Herein, a morphologically controllable Fe3O4@SiO2 magnetic…

Sci Adv. 2026 Jun 12;12(24):eaef3323. doi: 10.1126/sciadv.aef3323. Epub 2026 Jun 10. ABSTRACT Systemic metabolic disorders such as diabetes and hyperuricemia demand multiorgan therapeutic intervention, yet single-target therapies often fail to restore homeostasis. Here, we present an orally administered, multistage-targeted nanoplatform (P1P2NPs) for the sequential delivery of therapeutic peptides to distinct organs. P1P2NPs is composed of…

Structure. 2026 Jun 10:S0969-2126(26)00153-X. doi: 10.1016/j.str.2026.05.007. Online ahead of print. ABSTRACT GPR119 is a promising therapeutic target for metabolic diseases, yet the structural basis for its ligand-dependent efficacy remains unclear. Here, we report the cryo-EM structure of GPR119 bound to the partial agonist AS1269574 and Gs protein, revealing a non-canonical ligand-binding mode. Unlike full agonists,…

J Ethnopharmacol. 2026 Jun 10:121934. doi: 10.1016/j.jep.2026.121934. Online ahead of print. ABSTRACT ETHNOBOTANICAL RELEVANCE: Smyrnium olusatrum L. (Apiaceae), commonly known as Alexanders, has been traditionally used in Mediterranean ethnomedicine to alleviate digestive disorders, gastric discomfort, and inflammatory conditions. However, its gastroprotective and anti-Helicobacter pylori properties have not yet been scientifically investigated. Given that oxidative stress…

NPJ Digit Med. 2026 Jun 10. doi: 10.1038/s41746-026-02884-z. Online ahead of print. ABSTRACT Premature rupture of membranes (PROM) and preterm PROM (PPROM) are significant obstetric complications, affecting 10-20% and 3% of pregnancies globally and constituting a major cause of preterm birth and neonatal morbidity. While intrauterine infection is a key underlying driver, timely identification of…

Angew Chem Int Ed Engl. 2026 Jun 10:e5317513. doi: 10.1002/anie.5317513. Online ahead of print. ABSTRACT Developing artificial antioxidases represents a promising strategy for treatment of oxidative-stress-related disorders; however, their practical application is often hindered by insufficient catalytic activity. Here, we report a dual-cobalt coordinated phthalocyanine carboxylate derivative (biCoPc) as an efficient artificial antioxidase with markedly…

Angew Chem Int Ed Engl. 2026 Jun 11:e6720227. doi: 10.1002/anie.6720227. Online ahead of print. ABSTRACT Nucleoside-5′-triphosphates (NTPs) are important building blocks for nucleic acids, but the efficiency of their chemical synthesis is limited by the low yield of the final 5′-triphosphorylation reaction. Here, we present an enzymatic cascade reaction involving just two enzymes that enable…