Adv Mater. 2026 Jun 12:e73688. doi: 10.1002/adma.73688. Online ahead of print. ABSTRACT Enzymatic cascade systems enhance the efficiency of biocatalysis by mimicking natural metabolic pathways. However, conventional platforms face challenges such as ineffective enzyme distribution, uncontrolled stoichiometry, limited substrate accessibility, and a microenvironment that is suboptimal for enzyme performance. Inspired by cellular biomolecular condensates, we…

Adv Colloid Interface Sci. 2026 Jun 10;356:103972. doi: 10.1016/j.cis.2026.103972. Online ahead of print. ABSTRACT Biocatalysis is an important component of the tool-box for sustainable chemistry in general and organic synthesis in particular. In recent times, focus of applied enzymology has shifted from the reactions catalyzed by single enzymes to more ambitious applications of bio-inspired multi-enzyme…

J Colloid Interface Sci. 2026 Jun 8;722:140858. doi: 10.1016/j.jcis.2026.140858. Online ahead of print. ABSTRACT Whole-cell catalysis enables the integration of multiple enzymatic functions within a single living system, but its broader application is often constrained by poor operational stability and limited mass transfer under non-physiological conditions. Material-assisted immobilization offers a route to enhance stability, yet…

Small. 2026 Jun 11:e74049. doi: 10.1002/smll.74049. Online ahead of print. ABSTRACT Active enzymes generate significant mechanical fluctuations while catalyzing chemical reactions, which can influence the dynamics of their surroundings. This phenomenon opens new avenues for controlling mass transport in complex and dynamically inhomogeneous environments through localized chemical reactions. Herein, we studied the uptake of transferrin…

ACS Nano. 2026 Jun 11. doi: 10.1021/acsnano.6c02436. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) involves oxidative stress, chronic inflammation, and gut microbiota dysbiosis, complicating therapeutic intervention. Herein, we engineer a robust living therapeutic platform via a biomimetic nanoarmoring strategy. A uniform FDA-approved calcium carbonate (CaCO3) nanocoating is in situ mineralized on the surface…

Biology (Basel). 2026 Jun 3;15(11):885. doi: 10.3390/biology15110885. ABSTRACT Beta-alanine, a naturally occurring non-proteinogenic beta-amino acid, is widely used in delaying fatigue, enhancing exercise performance, and alleviating hyperuricemia. It also serves as a three-carbon platform for the synthesis of various high-value compounds, thus showing extremely broad market prospects. However, the practical application of beta-alanine is severely…

Photochem Photobiol Sci. 2026 Jun 11. doi: 10.1007/s43630-026-00932-x. Online ahead of print. ABSTRACT Luciferyl-adenylate (LH2AMP) is the key chemiluminescent intermediate in the bioluminescence reaction catalyzed by beetle luciferases. Whereas the luciferase-catalyzed bioluminescence reactions usually proceed with high quantum yields in the green-yellow region, the chemiluminescence of LH2AMP is almost always in the red region. To…

J Agric Food Chem. 2026 Jun 11. doi: 10.1021/acs.jafc.6c04174. Online ahead of print. ABSTRACT Serotonin (5-hydroxytryptamine, 5-HT) plays a critical role in maintaining intestinal health, regulating mood and sleep, and enhancing crop stress tolerance. Here, a Bacillus licheniformis cell factory was developed for the sustainable and efficient synthesis of 5-HT. First, a tryptophan-producing chassis strain,…

ChemSusChem. 2026 Jun 15;19(11):e202502620. doi: 10.1002/cssc.202502620. ABSTRACT Selective and catalytic Michael addition reactions are highly valuable transformations in various domains of chemical and biological sciences and key methods for the sustainable synthesis of more complex compounds from two simpler starting compounds. High atom economy is achieved by forming two novel bonds and by the conversion…