Angew Chem Int Ed Engl. 2026 Jun 16:e2408585. doi: 10.1002/anie.2408585. Online ahead of print. ABSTRACT Microbial artificial photosynthesis offers a promising strategy for light-driven biomanufacturing, yet its efficiency remains limited by the non-selective conversion of photogenerated electrons into metabolically usable reducing power, causing energy dissipation and weak coupling between light capture and metabolic reactions. Here,…

ACS Omega. 2025 Nov 6;11(22):31909-31924. doi: 10.1021/acsomega.5c07104. eCollection 2026 Jun 9. ABSTRACT This study explored the production of activated carbon from cocoa bean shells (CBS), both before and after solid-state fermentation, and evaluated its potential as a support for enzyme immobilization in aroma ester synthesis. Fermentation improved the physicochemical properties of the shells, increasing surface…

J Chem Theory Comput. 2026 Jun 15. doi: 10.1021/acs.jctc.6c00526. Online ahead of print. ABSTRACT In this work, we extended the book-ending framework with a hybrid quantum-classical workflow that incorporates configuration interaction (CI) calculations into alchemical free energy (AFE) predictions. In the book-ending approach, the Multistate Bennett Acceptance Ratio (MBAR) is applied along a coupling parameter…

Eur J Med Chem. 2026 Jun 13:119067. doi: 10.1016/j.ejmech.2026.119067. Online ahead of print. NO ABSTRACT PMID:42288435 | DOI:10.1016/j.ejmech.2026.119067

Plant Commun. 2026 Jun 15:101965. doi: 10.1016/j.xplc.2026.101965. Online ahead of print. ABSTRACT Limonoids are a structurally diverse class of highly oxidized triterpenoids produced by Meliaceae and Rutaceae species. They exhibit remarkable biological activities but are difficult to produce due to their complex biosynthesis. Plants evolve ecologically adaptive specialized metabolites through the amplification and functional differentiation…

Small. 2026 Jun 15:e74185. doi: 10.1002/smll.74185. Online ahead of print. ABSTRACT DNA nanotechnology enables the precise assembly of complex and versatile 2-dimensional (2D) and 3-dimensional (3D) nanostructures. Coupling enzymes to such DNA nanostructures offers great control over the enzymes’ positioning and stoichiometry to modify their activity and unleash their maximum catalytic capacity. While enzymes hosted…

Chembiochem. 2026 Jun 15;27(11):e202500344. doi: 10.1002/cbic.202500344. ABSTRACT Ribonucleotide reductases (RNRs) catalyze one of the central biochemical reactions, giving rise to deoxyribonucleotides, the building blocks of DNA. Due to their importance in cellular metabolism, this class of enzymes has been extensively studied over five decades. One aspect that has been neglected so far is the substrate…

Research (Wash D C). 2026 Jun 11;9:1293. doi: 10.34133/research.1293. eCollection 2026. ABSTRACT Nanozymes overcome key limitations of natural enzymes, including poor environmental tolerance, high production costs, and batch-to-batch variability, with their enhanced physicochemical stability and controllable catalytic performance, thus enabling applications in biocatalysis and disease theranostics. However, their practical applications remain limited by insufficient catalytic…

ACS Omega. 2026 May 24;11(22):31949-31956. doi: 10.1021/acsomega.5c10753. eCollection 2026 Jun 9. ABSTRACT Enzyme-hybrid nanoflowers (EHN) have attracted substantial interest in biocatalysis due to their high surface area and enhanced catalytic activity compared with free enzymes. Although extensively studied in solution, their integration into solid supports remains limited. Here, thin films composed of urease/Cu2+ hybrid nanoflowers…