BioCat Collective

Educating and Building a Broader Biocatalysis Community

Category: Biocatalysis

  • Ferula gummosa in colorectal cancer: a bioinformatics and experimental validation study

    Res Pharm Sci. 2026 May 10;21(3):346-363. doi: 10.4103/RPS.RPS_246_24. eCollection 2026 Jun. ABSTRACT BACKGROUND AND PURPOSE: Colorectal cancer (CRC) is a significant global health challenge, necessitating a comprehensive molecular understanding for personalized treatments. Molecular profiling has elucidated key biomarkers that are essential for prognosis, treatment responsiveness, and targeted therapeutic interventions. EXPERIMENTAL APPROACH: This study explored the…

  • Structural basis of Drosophila insulin receptor activation by DILP2 hormone

    Open Biol. 2026 Jun 17;16(6):250351. doi: 10.1098/rsob.250351. ABSTRACT Insulin-related hormones regulate key life processes in the animal kingdom, from metabolism to growth, lifespan and ageing, through an evolutionarily conserved insulin and insulin-like hormones signalling axis (IIS). In humans, the IIS axis is controlled by insulin, two insulin-like growth factors, two isoforms of the insulin receptor…

  • Photoenzymatic new-to-nature transformations via electron donor-acceptor complexes

    Org Biomol Chem. 2026 Jun 1. doi: 10.1039/d6ob00560h. Online ahead of print. ABSTRACT Recent advances have demonstrated that certain enzymes utilizing photoactive cofactors can be redirected upon light excitation to catalyze reactions entirely unrelated to their evolved functions. Given that charge-transfer interactions between substrates and cofactors can be facilitated by the spatial proximity afforded by…

  • Impact of phospholipase A2 hydrolysis on triplet-triplet annihilation upconversion liposomes

    J Mater Chem B. 2026 Jun 12. doi: 10.1039/d6tb00152a. Online ahead of print. ABSTRACT Triplet-triplet annihilation upconversion (TTA-UC) liposomes are of emerging interest because of their potential bioapplications in biosensing/imaging and light-driven therapeutic delivery. However, a potential challenge in vivo is their stability, since liposomes are prone to enzymatic degradation. Here, for the first time,…

  • Development of Peroxymonosulfate Catalytic System and Photoenzymatic Catalytic System Utilizing Zn-Doped g-C(3)N(4) for the Degradation of Methylene Blue in Water

    Langmuir. 2026 Jun 16. doi: 10.1021/acs.langmuir.6c00112. Online ahead of print. ABSTRACT The excessive discharge of wastewater containing methylene blue (MB) has caused certain adverse effects on human health and daily life. This highlights the urgent need for the development of safe and environmentally friendly methods of degradation. In this study, two catalytic systems based on…

  • Natural products with atypical atoms: unveiling structures, biosynthetic pathways, and bioactivities

    Nat Prod Rep. 2026 Jun 4. doi: 10.1039/d5np00083a. Online ahead of print. ABSTRACT Covering: 1944-2025Nature’s biosynthetic repertoire extends far beyond conventional CHON(S) chemistry and encompasses a rare but diverse array of natural products that incorporate atypical elements such as arsenic, selenium, fluorine, iodine, boron, and vanadium. These metabolites reveal how living systems have evolved to…

  • Enzyme-catalysed synthesis of pyridines from biomass-derived feedstocks

    Org Biomol Chem. 2026 Jun 11. doi: 10.1039/d6ob00839a. Online ahead of print. ABSTRACT Pyridines are found in many pharmaceuticals and agrochemicals, but are synthesised from fossil fuel conversion. 2,4- and 2,5-pyridinedicarboxylic acids have been reported as products from bioconversion of renewable lignin feedstocks using engineered strains of Rhodococcus jostii RHA1 (Z. Mycroft et al., Green…

  • Compartmentalized Encapsulation of Rhodium-Alginate Conjugate in Hybrid Hydrogen-Bonded Organic Frameworks for In Situ Cofactor Recycling and Biocatalysis

    ACS Appl Mater Interfaces. 2026 Jun 16. doi: 10.1021/acsami.6c05788. Online ahead of print. ABSTRACT Sustainable enzymatic reactions with nicotinamide adenine dinucleotide (phosphate) (NAD(P))-dependent oxidoreductases need cofactor regeneration, and a pentamethylcyclopentadienyl rhodium (Rh) bipyridine complex has been recognized as a promising chemical catalyst for this purpose. However, efficient cofactor recycling using Rh catalysts faces challenges in…

  • Triad of electrocatalytic strategies for polymer monomer synthesis

    Chem Soc Rev. 2026 Jun 4. doi: 10.1039/d6cs00501b. Online ahead of print. ABSTRACT Electrocatalysis provides a green and scalable route for synthesizing polymer monomers directly from renewable feedstocks such as water, CO2, and biomass derivatives. This review delineates the evolution of electrocatalytic strategies, presenting a progressively advancing framework, from elementary transformations to integrated catalytic systems.…

  • Harnessing the Versatility of SAM-Dependent Enzymes: From Mechanism to Application

    Chembiochem. 2026 Jun 15;27(11):e70416. doi: 10.1002/cbic.70416. ABSTRACT S-Adenosyl-L-methionine (SAM) is a central biological cofactor that supplied activated methyl groups and enables a broad-spectrum biochemical transformation. Beyond canonical SN2 methyl transfer, SAM-dependent enzymes could initiate radical-mediated chemistry via reductive SAM cleavage, enabling versatile reactions from methyl transfer to alkylation, isomerization, and decarboxylation. Despite their extraordinary catalytic…