Educating and Building a Broader Biocatalysis Community
Mater Today Bio. 2026 Mar 31;38:103072. doi: 10.1016/j.mtbio.2026.103072. eCollection 2026 Jun. ABSTRACT [This corrects the article DOI: 10.1016/j.mtbio.2025.101548.]. PMID:42327660 | PMC:PMC13282581 | DOI:10.1016/j.mtbio.2026.103072
Acta Crystallogr D Struct Biol. 2026 Jul 1. doi: 10.1107/S2059798326005954. Online ahead of print. ABSTRACT Flavin-dependent halogenases (FDHs) offer a biocatalytic route to regioselective halogenation of aromatic substrates under mild conditions. AetF, a rare self-sufficient single-component FDH, catalyzes sequential dibromination of tryptophan and has a broad substrate scope. Here, we report the crystal structure of…
Org Lett. 2026 Jun 21. doi: 10.1021/acs.orglett.6c01832. Online ahead of print. ABSTRACT A chemoenzymatic strategy to construct aryl-substituted chiral quaternary carbon centers has been established. Directed evolution of P450BM3 enables highly enantioselective epoxidation of tertiary allylic alcohols (up to 99% ee), which is a formidable challenge in chemical synthesis. The resulting chiral epoxides undergo acid-catalyzed…
Chem Rec. 2026 Jun 21:e70197. doi: 10.1002/tcr.70197. Online ahead of print. ABSTRACT The importance of catalysis in the development of waste management systems in the circular economy is undeniable. This review emphasizes the emerging potential of nature-based bio-inspired catalysis to advance waste valorization. It discusses the potential of bio-inspired catalysis for waste valorization over the…
Int J Biol Macromol. 2026 Jun 21:153150. doi: 10.1016/j.ijbiomac.2026.153150. Online ahead of print. ABSTRACT Cytochrome P450 (CYP450) proteins are a vital enzyme superfamily involved in drug metabolism, detoxification, and biosynthesis. Accurate identification of CYP450 proteins in large-scale proteomic datasets is crucial for advancing pharmacogenomics and industrial biocatalysis. However, current methods are limited by the high…
Bioresour Technol. 2026 Jun 21:135213. doi: 10.1016/j.biortech.2026.135213. Online ahead of print. ABSTRACT The convergence of interdisciplinary fields such as nanoscience and bioscience has given rise to novel strategies for wastewater remediation. As a result of this convergence, light-driven biohybrid systems, which integrate photocatalysis and biocatalysis, offer a promising route for wastewater treatment. In particular, the…
Cell Mol Biol (Noisy-le-grand). 2026 Mar 31;72(3):54-62. doi: 10.14715/cmb/2025.72.3.7. ABSTRACT Plasmodium falciparum is the most dangerous malaria parasite affecting humans. Compounds such as mukonal, 7-hydroxymukonal, and 7-methoxymukonal have shown potential for the treatment of this disease. Density Functional Theory (DFT), molecular docking, and pharmacokinetic analyses are valuable computational approaches for predicting potential drug candidates against…
Bioresour Technol. 2026 Jun 20:135184. doi: 10.1016/j.biortech.2026.135184. Online ahead of print. ABSTRACT Enzymatic polymer synthesis emerges as a sustainable alternative to chemical methods, operating under mild and environmentally benign conditions. Integrating enantioselective synthesis with polymerisation enables the use of nonpolymerisable and prochiral molecules as monomers for biodegradable plastics. Here, the scale-up of a biocatalytic asymmetric…
Biotechnol Adv. 2026 Jun 20:108955. doi: 10.1016/j.biotechadv.2026.108955. Online ahead of print. ABSTRACT Polyethylene terephthalate (PET) waste remains a major environmental and resource challenge, and enzymatic depolymerization offers a promising route for recovering terephthalic acid and ethylene glycol under aqueous conditions for closed-loop PET recycling. However, the practical deployment of PET-degrading enzymes is constrained by substrate…
Biophys Rev. 2026 Feb 17;18(2):307-325. doi: 10.1007/s12551-026-01418-x. eCollection 2026 Apr. ABSTRACT Protein nanopores have evolved into a powerful biophysical tool, from direct DNA sequencing to versatile molecular sensors that detect RNA, proteins, aptamers, and low-molecular-weight analytes. This review summarizes the current state of nanopore technologies for biopolymer sequencing and metabolite detection and discusses prospects for…