NPJ Drug Discov. 2026 May 4;3(1):15. doi: 10.1038/s44386-026-00045-6. ABSTRACT Antimicrobial peptides (AMPs) are promising alternatives to conventional antibiotics against bacterial infections. However, the discovery of AMPs is impeded by the limitations of biochemical screening and the difficulty computational approaches face in balancing efficacy with structural diversity. We proposed an integrated “generation-evaluation-validation” framework to facilitate de…

Angew Chem Int Ed Engl. 2026 Jun 30:e8664414. doi: 10.1002/anie.8664414. Online ahead of print. ABSTRACT Living systems organize electron flow through continuous, spatially and energetically structured redox networks, whereas most synthetic light-driven bioelectronic platforms rely on abiotic materials to generate and inject electrons into cells, limiting selective coupling between living partners. Here, we report programmable…

Microbiome. 2026 Jun 29. doi: 10.1186/s40168-026-02394-w. Online ahead of print. ABSTRACT BACKGROUND: Human Leukocyte Antigen (HLA) class-II genes, particularly HLA-DR2 and HLA-DR3, and the gut microbiota are intricately linked to the pathobiology of multiple sclerosis (MS) through their ability to regulate host immunity, a critical factor in disease pathogenesis. An imbalance between anti-inflammatory CD4+ Tregs…

Plant Commun. 2026 Jun 29:101982. doi: 10.1016/j.xplc.2026.101982. Online ahead of print. ABSTRACT Polyploidization drives evolutionary innovation and crop domestication by leveraging novel gene combinations and increased genetic variation. Although tetraploid rice shows promise for yield enhancement due to its larger grains, the underlying regulatory mechanisms remain unclear. In this study, using tetraploid rice CX35-4x and…

Angew Chem Int Ed Engl. 2026 Jun 30:e4831016. doi: 10.1002/anie.4831016. Online ahead of print. ABSTRACT Controlling biocatalytic activity in melt-processed polymers is a central challenge for triggered depolymerization, because enzymes deactivate at melt-extrusion temperatures. Here, metal-organic framework-gated biocatalysis, achieved by encapsulating enzymes within zeolitic imidazolate framework-8 (ZIF-8), preserves > 85% activity after 2 min at…

Enzyme Microb Technol. 2026 Jun 22;200:110927. doi: 10.1016/j.enzmictec.2026.110927. Online ahead of print. ABSTRACT Enzymes are indispensable biocatalysts; however, their industrial and environmental applications are often constrained due to their narrow pH ranges. This review provides a comprehensive overview of computational-guided strategies for rationally engineering enzyme pH profiles, shifting optima, broadening functional windows, and enhancing acid-…

J Biol Chem. 2026 Jun 29:113300. doi: 10.1016/j.jbc.2026.113300. Online ahead of print. ABSTRACT Reactive α-oxoaldehydes, such as glyoxal (GO) and methylglyoxal (MGO), are cytotoxic glycolysis byproducts that induce cellular dysfunction by non-enzymatically modifying diverse macromolecules. Although DJ-1 (PARK7), a protein linked to Parkinson’s disease, acts as a type-III glyoxalase/methylglyoxalase, the physiological function(s) of its prokaryotic…

Bioresour Technol. 2026 Jun 29:135271. doi: 10.1016/j.biortech.2026.135271. Online ahead of print. ABSTRACT 1-Deoxynojirimycin (1-DNJ) is a potent α-glucosidase inhibitor and a highly promising next-generation hypoglycemic agent, however, the catalytic efficiencies of its critical synthetases GabT1, YktC1 and GutB1 (TYB) are relatively low, which severely limits its large-scale production, and this research aimed to establish a…