Sci China Life Sci. 2026 Jun 29. doi: 10.1007/s11427-025-3350-2. Online ahead of print. NO ABSTRACT PMID:42400711 | DOI:10.1007/s11427-025-3350-2

Biotechnol Adv. 2026 Jul 4:108974. doi: 10.1016/j.biotechadv.2026.108974. Online ahead of print. ABSTRACT Foodborne pathogenic microorganisms pose serious threats to public health, underscoring the critical need for rapid detection methods. Biosensors serve as promising alternatives by integrating biorecognition elements with signal transduction systems, enabling efficient and specific detection of such pathogens. This review systematically summarizes the…

J Comput Chem. 2026 Jul 5;47(18):e70446. doi: 10.1002/jcc.70446. ABSTRACT The RNA interference (RNAi) pathway regulates gene expression and viral defense and has been harnessed in therapeutic solutions to inhibit otherwise undruggable proteins by preventing translation. Dicer initiates RNAi by generating cleaved RNA products that bind to a target mRNA to promote gene silencing. Mutations to…

Biotechnol Adv. 2026 Jul 3:108965. doi: 10.1016/j.biotechadv.2026.108965. Online ahead of print. ABSTRACT Cell surface display technology is a powerful biotechnological tool to anchor heterologous proteins onto the microbial cell surface by fusing them with membrane-anchoring carrier proteins. It makes biocatalysis more efficient by allowing enzymes to access substrates without cell lysis or protein purification. This…

Sci Rep. 2026 Jul 3. doi: 10.1038/s41598-026-60806-1. Online ahead of print. ABSTRACT Deep eutectic solvents (DESs) are promising green media for biocatalysis, yet their application in pyruvate decarboxylase (PDC)-mediated phenylacetylcarbinol (PAC) biotransformation with product separation remains limited. This study screened nine DESs using frozen-thawed whole cells (FT-WHC) of Candida magnoliae (C. mag.), followed by evaluation…

Colloids Surf B Biointerfaces. 2026 Jun 29;267:115943. doi: 10.1016/j.colsurfb.2026.115943. Online ahead of print. ABSTRACT The regulation of multiphase interfacial reactions is a central challenge in heterogeneous catalysis, where interfacial physicochemical properties govern reaction efficiency and selectivity. Lipase-catalyzed lipid transformations represent a prototypical model for biocatalysis at soft interfaces. Lipase activity is intrinsically dependent on lipid-water…

J Chem Theory Comput. 2026 Jul 2. doi: 10.1021/acs.jctc.6c00480. Online ahead of print. ABSTRACT Elucidating protein dynamics is crucial for deciphering fundamental biological processes, from enzyme catalysis to cellular signaling, as its dysregulation directly causes protein misfolding diseases such as Alzheimer’s and Parkinson’s. While artificial intelligence has revolutionized static protein structure prediction, capturing the high-dimensional…

RSC Adv. 2026 Jul 2. doi: 10.1039/d6ra02193j. Online ahead of print. ABSTRACT The quinazolinone moieties are common in bioactive molecules, and novel variations of these compounds, preferably generated by sustainable methods, are of interest. Incorporating biocatalysis into the synthesis of active pharmaceutical ingredients offers significant advantages, mainly because enzymes have excellent specificity. In this work,…

Commun Chem. 2026 Jul 2. doi: 10.1038/s42004-026-02105-4. Online ahead of print. ABSTRACT Significant achievements have been made in the design of functional metalloenzymes. However, more convenient and versatile approaches are still needed to design multifunctional heme enzymes with broader substrate scope for potential applications such as bioremediation. Using myoglobin (Mb) as a model protein, we…