Educating and Building a Broader Biocatalysis Community
Chem Bio Eng. 2026 Mar 26;3(7):641-649. doi: 10.1021/cbe.5c00167. eCollection 2026 Jul 23. ABSTRACT The development and validation of a mathematical model for a highly integrated biocatalytic process are presented. A multienzymatic cascade comprising three parallel and sequential reaction steps was implemented in a miniplant setup, integrating an enzyme membrane reactor (EMR) and a reactive extraction…
Adv Colloid Interface Sci. 2026 Jul 25;357:103996. doi: 10.1016/j.cis.2026.103996. Online ahead of print. ABSTRACT Enzymes are excellent biological catalysts that facilitate certain biochemical reactions; nevertheless, their structural fragility, inadequate operational stability, and restricted reusability hinder their extensive commercial adoption. Enzyme immobilization has become a viable approach to overcome these limitations, with supramolecular hydrogels (SMHs) receiving…
Angew Chem Int Ed Engl. 2026 Jul 27:e7795967. doi: 10.1002/anie.7795967. Online ahead of print. ABSTRACT The dynamic glycan layer that surrounds human and microbial cells plays an essential role in the immune system’s capacity to maintain immune tolerance and equilibrium, fight pathogens and cancer. Endogenous anti-glycan antibodies are an indispensable part of immune surveillance, identifying…
Angew Chem Int Ed Engl. 2026 Jul 27:e8706793. doi: 10.1002/anie.8706793. Online ahead of print. ABSTRACT The development of therapeutic nucleic acids has become a cornerstone of modern drug discovery. To support the clinical translation of these modalities, radiolabelled analogues are vital for absorption, distribution, metabolism and excretion (ADME) studies, particularly for quantitative whole-body autoradiography (QWBA).…
Anal Chem. 2026 Jul 26. doi: 10.1021/acs.analchem.6c02230. Online ahead of print. ABSTRACT Halogenases are attractive catalysts to facilitate asymmetric Csp3-halogenation of organic molecules. Traditional halogen insertion reactions employ hazardous reagents and are notoriously unselective, but asymmetric halogenation of drug molecules offers control over pharmacokinetic properties. To date, the toolbox of halogenases to facilitate Csp3-halogenation, and…
New Phytol. 2026 Jul 27. doi: 10.1111/nph.71462. Online ahead of print. ABSTRACT Cytoplasmic male sterility (CMS) is widely used in rapeseed hybrid breeding. The Polima (pol) CMS system is associated with the mitochondrial chimeric gene orf224, yet how it disrupts early anther differentiation and leads to sterility remains unclear. We combined cytological analyses, ultrastructural observations,…
Chembiochem. 2026 Jul 29;27(14):e70477. doi: 10.1002/cbic.70477. ABSTRACT Electroactive microbes, such as Shewanella oneidensis MR-1, have been harnessed for a variety of bioelectrochemical and catalytic applications. Efforts to improve the electrochemical performance of these bacteria have included the use or biological synthesis of small-molecule redox mediators, such as flavins. However, limited redox range and complex biosynthetic…
Curr Res Struct Biol. 2026 Jul 16;12:100197. doi: 10.1016/j.crstbi.2026.100197. eCollection 2026 Dec. ABSTRACT The enzymes Cannabichromenic Acid Synthase (CBCAS), Cannabidiolic Acid Synthase (CBDAS) and Tetrahydrocannabinolic Acid Synthase (THCAS) are together the major cannabinoid synthase enzymes responsible for the biosynthesis of their respective metabolites from a common precursor Cannabigerolic Acid (CBGA). As the catalysts responsible for…
J Colloid Interface Sci. 2026 Jul 21;724(Pt 2):141187. doi: 10.1016/j.jcis.2026.141187. Online ahead of print. ABSTRACT Enzyme confinement at the molecular scale reveals catalytic performance that is previously unseen at the ensemble level, but all such delicate enzyme hosts now available encounter their intrinsic issues. Here, we present a mild, one-pot emulsification-directing approach to customize colloidosomes…
Metab Eng. 2026 Jul 25:102506. doi: 10.1016/j.ymben.2026.102506. Online ahead of print. ABSTRACT Flavonolignans are pharmacologically important plant natural products whose production has been limited to extraction from natural sources. Their defining transformation, the oxidative coupling of flavonoid and phenylpropanoid precursors, was demonstrated to be enzyme-catalyzed. Here we show that milk thistle flavonolignans can also be…