BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Bioresour Technol. 2026 Aug 10:135599. doi: 10.1016/j.biortech.2026.135599. Online ahead of print. ABSTRACT Efficient valorization of lignin-derived aromatics remains a key challenge in sustainable chemistry. Biobased aromatic alcohols and esters are important value-added compounds widely used in fragrances, pharmaceutical intermediates, fine chemicals, and functional materials. In this study, a whole-cell biocatalytic system co-expressing alcohol dehydrogenase (ADH6)…
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Methods Mol Biol. 2026;3069:89-102. doi: 10.1007/978-1-0716-5508-5_6. ABSTRACT Activity-based ubiquitin probes serve as crucial tools for capturing and elucidating the molecular mechanisms of E3 ligase-catalyzed substrate ubiquitination. We recently reported a chemoenzymatic strategy for generating ubiquitin chain extension probes, which offers advantages such as mild reaction conditions, simple operation, and high specificity, thereby providing new opportunities…
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Synth Syst Biotechnol. 2026 Aug 1;17:26-38. doi: 10.1016/j.synbio.2026.07.005. eCollection 2027 Mar. ABSTRACT Industrial enzymes are widely used in diverse applications, but low productivity limits their further widespread utilization. This research aimed to develop high-performance alkaline protease (AprE) expression strains of Bacillus licheniformis through element optimization and modular engineering. Firstly, the aprE gene expression cassette was…
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Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts for lignin degradation, current knowledge…
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Mater Today Bio. 2026 Jul 28;39:103505. doi: 10.1016/j.mtbio.2026.103505. eCollection 2026 Aug. ABSTRACT The clinical efficacy of peptide-based cancer vaccines is limited by inefficient lymphatic delivery and suboptimal antigen presentation. Here, we report a rationally engineered class of lipid-antigen conjugates that co-enhance lymph node (LN) targeting and antigen-presenting cell (APC) uptake through molecular-level structural optimization. By…
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Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts for lignin degradation, current knowledge…
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Angew Chem Int Ed Engl. 2026 Aug 8:e6337773. doi: 10.1002/anie.6337773. Online ahead of print. ABSTRACT Stereogenic aminals are widespread in natural products, pharmaceuticals, and biologically active compounds, including important classes of antibiotics. Methodologies for asymmetric synthesis of aminals are therefore highly desirable, yet they remain scarce and mostly rely on C─N bond formation at functionalized…
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Mol Biotechnol. 2026 Aug 8. doi: 10.1007/s12033-026-01601-1. Online ahead of print. ABSTRACT Functional protein particles are emerging as versatile biomaterials with applications spanning nano-designs, drug delivery and biocatalysis. Their inherent biocompatibility, structural stability, and genetic modularity, when combined with nanoscale engineering, allow for the design of customizable systems with diverse functionalities. However, the reliable assembly…
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Highly Enantioselective Synthesis of Halogenated Cyclopropanes via Enzyme Catalyzed Carbene Transfer
ChemCatChem. 2025 Oct 8;17(19):e00949. doi: 10.1002/cctc.202500949. Epub 2025 Aug 1. ABSTRACT Halogenated cyclopropanes are highly desirable building blocks for both agrochemical and medicinal chemistry due to their unique structural features and ability to interact with biological targets through halogen bonds. However, methods for the highly diastreo- and enantioselective synthesis of these molecules are underdeveloped. Herein,…
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Isr J Chem. 2026 Sep;66(5):e70036. doi: 10.1002/ijch.70036. Epub 2026 Aug 5. ABSTRACT In the cell wall of Gram-positive bacteria, wall teichoic acid (WTA) is an abundant and conserved virulence factor. WTAs are especially relevant to methicillin-resistant Staphylococcus aureus. Tremendous synthetic efforts have permitted investigations of the terminal end of this glycopolymer. However, the peptidoglycan (PG)…