J Am Chem Soc. 2026 Aug 12;148(31):33004-33016. doi: 10.1021/jacs.5c23035. ABSTRACT Understanding redox enzymatic reactions remains a fundamental challenge in biochemistry, as these processes involve intricate dynamics that are inherently difficult to dissect using conventional bulk techniques. Single-enzyme catalysis offers a promising approach for unraveling the dynamic behavior of individual enzymes as they undergo a reaction,…

Curr Microbiol. 2026 Aug 12;83(10):510. doi: 10.1007/s00284-026-05091-x. ABSTRACT Laccase, with its wide substrate range, has significant potential in industrial biocatalysis, where agricultural waste has attracted considerable interest as an economical and sustainable alternative as a low-cost source for enzyme production. In this study, the effect of various factors (different aromatic compounds, carbon and nitrogen nutrient…

J Agric Food Chem. 2026 Aug 12;74(31):24593-24601. doi: 10.1021/acs.jafc.6c08855. ABSTRACT Amylosucrase efficiently synthesizes sucrose isomers, including turanose, a low-glycemic functional sweetener. In this study, an amylosucrase from Bifidobacterium boum (BbAS) was identified through sequence-based analysis, which predicted favorable thermostability. Molecular dynamics simulations revealed that the B’-domain residues at the active-site entrance exhibited reduced flexibility in…

J Agric Food Chem. 2026 Aug 12;74(31):24501-24512. doi: 10.1021/acs.jafc.6c05396. ABSTRACT Lignocellulosic biomass, which consists primarily of cellulose, hemicellulose, and lignin, is a promising renewable feedstock for producing high-value biobased amines. In this study, an integrated chemobiocatalytic strategy was developed to synthesize furfurylamine from corncob using a newly formulated deep eutectic solvent, [Bet][FA][LA], that provides both…

J Agric Food Chem. 2026 Aug 12;74(31):24583-24592. doi: 10.1021/acs.jafc.6c07161. ABSTRACT Lignocellulosic biomass is a renewable and abundant resource for producing high-value chemicals as sustainable alternatives to petroleum-derived products. Among these, 5-hydroxymethylfurfural (HMF) and furfural (FA), generated through catalytic dehydration of biomass-derived sugars, serve as pivotal intermediates for enzymatic synthesis of valuable platform chemicals like 2,5-furandicarboxylic…

J Agric Food Chem. 2026 Aug 12;74(31):24513-24522. doi: 10.1021/acs.jafc.6c04626. ABSTRACT (R)-citronellal is an important intermediate for aroma compounds and pharmaceuticals. Herein, we engineered the choline oxidase, AcCO6, from Arthrobacter chlorophenolicus, to enhance enantioselective oxidation of citronellol. Through site-directed and combinatorial mutagenesis, a quadruple mutant, AcCO6_M4a (W332V/A89S/W331F/N463E) was obtained, exhibiting 336% of the wild-type activity and…

Mater Today Bio. 2026 Jul 18;39:103464. doi: 10.1016/j.mtbio.2026.103464. eCollection 2026 Aug. ABSTRACT [This corrects the article DOI: 10.1016/j.mtbio.2025.102490.]. PMID:42582226 | PMC:PMC13457165 | DOI:10.1016/j.mtbio.2026.103464

Exploration (Beijing). 2026 Aug 10:70209. doi: 10.1002/exp2.70209. Online ahead of print. ABSTRACT The complex tumor microenvironment (TME) includes high concentrations of hydrogen peroxide, high expression of reduced glutathione (GSH), hypoxia, and the resulting immunosuppression from the combination of these features, posing major challenges in tumor therapy. Although nanozymes have demonstrated remarkable potential in treating malignant…

Biochem J. 2026 Sep 2;483(9):1631. doi: 10.1042/BCJ20250294_COR. NO ABSTRACT PMID:42583719 | DOI:10.1042/BCJ20250294_COR

Chem Soc Rev. 2026 Aug 12. doi: 10.1039/d5cs01574j. Online ahead of print. ABSTRACT Biomolecules are nature’s catalysts and recognition elements, yet their practical use is limited by instability and lack of reusability. Crystalline porous organic frameworks (POFs) have emerged as protective hosts, but the field is now shifting from passive encapsulation toward engineering multi-component synergy.…