BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
-
Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts for lignin degradation, current knowledge…
-
J Struct Biol X. 2026 Jul 31;14:100156. doi: 10.1016/j.yjsbx.2026.100156. eCollection 2026 Dec. ABSTRACT Allosteric regulation in biosynthetic L-threonine deaminase (BTD) has long been attributed to effector-induced conformational changes. Here, we identify a trans-interface coupling mechanism that regulates the active site architecture of EcIlvA, the BTD homolog of Escherichia coli. Starting from a low-activity, regulatory-domain-truncated variant…
-
J Insect Physiol. 2026 Aug 16:105049. doi: 10.1016/j.jinsphys.2026.105049. Online ahead of print. ABSTRACT Predation risk can shape prey behavior as strongly as direct killing, yet the non-lethal effects of predators on termites remain largely unknown. Current study investigated how chemical, contact, and soil-derived cues from fire ant Solenopsis invicta affect the behavior and physiology of…
-
Bioresour Technol. 2026 Aug 16:135646. doi: 10.1016/j.biortech.2026.135646. Online ahead of print. ABSTRACT Cyanidin-3-O-glucoside (C3G) is a water-soluble, value-added natural flavonoid with extensive applications in the nutraceutical and cosmetic industries. However, its efficient bioproduction is hampered by intermediate instability, metabolic imbalance and enzyme kinetic constraints. Here, we successfully constructed an efficient biosynthesis pathway from the dihydroquercetin…
-
Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts for lignin degradation, current knowledge…
-
Biosens Bioelectron. 2026 Aug 13;313:119126. doi: 10.1016/j.bios.2026.119126. Online ahead of print. ABSTRACT Unidirectional “signal-on/off” modalities remain a fundamental constraint in photoelectrochemical (PEC) biosensing, not only constricting dynamic range but also elevating susceptibility to false-positive or false-negative outcomes. To circumvent this limitation, we introduce an innovative “enzyme-gated precipitation-polarity reversal” (EGPPR) mechanism that inherently suppresses spurious signals…
-
ACS Sens. 2026 Aug 15. doi: 10.1021/acssensors.6c01202. Online ahead of print. ABSTRACT CRISPR/Cas12a holds great promise for biosensing and diagnostics, but conventional methods suffer from low catalytic efficiency, high background, and reliance on pre-amplification. Direct detection of structured RNAs also remains challenging. Herein, we report the development of a reverse transcriptase and LNA probe (LNA-p)-mediated…
-
Nat Plants. 2026 Aug 14. doi: 10.1038/s41477-026-02349-x. Online ahead of print. ABSTRACT Membraneless organelles play essential roles in many cellular processes. In various photosynthetic organisms, they are a crucial part of CO2/carbon-concentrating mechanisms (CCMs) that increase photosynthetic productivity. One example is the pyrenoid in Chlamydomonas reinhardtii, a liquid-phase-separated organelle that localizes and improves CO2 fixation…
-
Prep Biochem Biotechnol. 2026 Aug 6:1-26. doi: 10.1080/10826068.2026.2690415. Online ahead of print. ABSTRACT Lignin is one of the most abundant yet recalcitrant biopolymers in nature, and its inefficient depolymerization remains a major bottleneck in lignocellulosic biomass valorization and sustainable biorefinery development. Although fungal oxidative enzymes have emerged as promising biocatalysts for lignin degradation, current knowledge…
-
Org Lett. 2026 Aug 14;28(32):10145-10150. doi: 10.1021/acs.orglett.6c01996. ABSTRACT A general and efficient P(III)-directed ruthenium-catalyzed C-H olefination of tertiary phosphines with alkenyl reagents is reported for modular synthesis of axially olefin-phosphines. This late-stage functionalization exhibits broad substrate scope for both phosphines and olefins. A diverse library of 55 olefin-phosphines was prepared in high yields, tolerating up…