Educating and Building a Broader Biocatalysis Community
Int J Biol Macromol. 2026 Aug 28:154222. doi: 10.1016/j.ijbiomac.2026.154222. Online ahead of print. ABSTRACT In this study, a previously uncharacterized neral reductase (an ene-reductase), SmNR (Serratia marcescens Neral Reductase), belonging to the Old Yellow Enzyme family, was identified and functionally characterized from Serratia marcescens HBQA7. SmNR efficiently catalyzes the asymmetric reduction of neral to produce…
Chem Sci. 2026 Aug 24. doi: 10.1039/d6sc05731d. Online ahead of print. ABSTRACT Molecular nanocarbons, including polycyclic aromatic hydrocarbons, cycloparaphenylenes, and carbon nanobelts, have emerged as structurally well-defined carbon-rich molecules with unique photophysical, electronic, and topological properties. Recent advances in synthetic organic chemistry have greatly expanded the accessible structural diversity of molecular nanocarbons, accelerating their exploration…
Angew Chem Int Ed Engl. 2026 Aug 28:e5856873. doi: 10.1002/anie.5856873. Online ahead of print. ABSTRACT Light-driven photoredox catalysis can shift intracellular NADH/NAD+ balance by oxidizing NADH, but intracellular NADH pools are dynamically replenished through enzyme-coupled redox metabolism. We show that ALDH-mediated restoration of NADH/NAD+ balance can buffer photoredox-induced NADH depletion, providing a design rationale for…
Int J Biol Macromol. 2026 Aug 28:154222. doi: 10.1016/j.ijbiomac.2026.154222. Online ahead of print. ABSTRACT In this study, a previously uncharacterized neral reductase (an ene-reductase), SmNR (Serratia marcescens Neral Reductase), belonging to the Old Yellow Enzyme family, was identified and functionally characterized from Serratia marcescens HBQA7. SmNR efficiently catalyzes the asymmetric reduction of neral to produce…
Metab Eng. 2026 Aug 28:102531. doi: 10.1016/j.ymben.2026.102531. Online ahead of print. ABSTRACT Lignin has potential as a sustainable feedstock to replace fossil fuels in chemical manufacturing. The coupling of chemical fractionation and biocatalysis has emerged as a promising technology to realize this potential. In this process, chemocatalytic fractionation of biomass or lignin yields heterogeneous mixtures…
Int J Biol Macromol. 2026 Aug 28:154222. doi: 10.1016/j.ijbiomac.2026.154222. Online ahead of print. ABSTRACT In this study, a previously uncharacterized neral reductase (an ene-reductase), SmNR (Serratia marcescens Neral Reductase), belonging to the Old Yellow Enzyme family, was identified and functionally characterized from Serratia marcescens HBQA7. SmNR efficiently catalyzes the asymmetric reduction of neral to produce…
Int J Biol Macromol. 2026 Aug 27:154248. doi: 10.1016/j.ijbiomac.2026.154248. Online ahead of print. ABSTRACT Bidirectional acetylation and deacetylation of small molecules by acetyltransferases (ATs) remain poorly understood. In this study, we present the structural, functional, and computational characterization of a chloramphenicol O-AT from Bacillus sp. PAMC22265 (AT65) that exhibits bidirectional catalytic activity toward the regiospecific…
Bioorg Chem. 2026 Aug 20;181:110423. doi: 10.1016/j.bioorg.2026.110423. Online ahead of print. ABSTRACT The escalating global crisis of antimicrobial resistance (AMR) poses a severe threat to public health, with bacterial biofilms and virulence factors exacerbating treatment failures in drug-resistant pathogens. Quorum sensing (QS), a density-dependent communication system, orchestrates biofilm formation, virulence expression, and resistance mechanisms in…
Front Plant Sci. 2026 Aug 12;17:1897693. doi: 10.3389/fpls.2026.1897693. eCollection 2026. ABSTRACT Tobacco root rot (TRR), caused by Fusarium oxysporum, poses a significant threat to tobacco production. Synthetic fungicides widely used to control this soil-borne pathogen frequently cause fungicide resistance and environmental contamination. Limonene, a natural terpene with potent antifungal activity, features low residue and high…
JACS Au. 2026 Aug 11;6(8):4410-4416. doi: 10.1021/jacsau.6c00921. eCollection 2026 Aug 24. ABSTRACT Enhancing enzyme performance without protein engineering remains a central challenge in biocatalysis. Here, we report the unusual discovery that nanoparticles densely functionalized with DNA, commonly known as spherical nucleic acids (SNAs), can bind enzymes without chemical conjugation, affinity tags, or engineered recognition motifs…