Bioorg Med Chem Lett. 2026 May 20:130691. doi: 10.1016/j.bmcl.2026.130691. Online ahead of print. ABSTRACT pH-labile linkers have garnered significant attention in biomedical applications, particularly in designing the stimuli-responsive carriers for targeted drug delivery systems. In the present work, we have synthesized G1-monoacrylate from G1-diacrylate using a chemoenzymatic approach, followed by the synthesis of glycerol-based β-thiopropionate…

Angew Chem Int Ed Engl. 2026 May 15:e5002594. doi: 10.1002/anie.5002594. Online ahead of print. ABSTRACT Core-xylosylated N-glycans represent a ubiquitous class of N-glycans widely distributed across nature. Recently, core-xylosylated N-glycans have attracted considerable attention in the medical field, as they could elicit strong immune responses. Notably, antibodies targeting core-xylosylated N-glycans could kill Schistosoma in vitro,…

Beilstein J Org Chem. 2026 May 5;22:683-690. doi: 10.3762/bjoc.22.53. eCollection 2026. ABSTRACT Depressin (1) is a soft coral-derived diterpenoid containing the typical bicyclo[12.1.0]pentadecane casbane skeleton and a C5-keto group. Key strategies for the synthesis of depressin, as well as its casbene skeleton reported so far focused on the formation of the challenging 14-membered ring system.…

Nucleic Acids Res. 2026 May 11:gkag471. doi: 10.1093/nar/gkag471. Online ahead of print. ABSTRACT The design of pathways to synthesize valuable molecules remains a central challenge in chemistry and biotechnology. Several computational retrosynthesis tools have been developed to address this problem, but their scope is often confined only to reactions in either synthetic organic chemistry or…

J Agric Food Chem. 2026 May 9. doi: 10.1021/acs.jafc.5c17010. Online ahead of print. ABSTRACT Contamination by foodborne pathogens, coupled with the “clean label” consumer trend, is driving the development of safe and effective antimicrobial alternatives. Bacteriocins from food-grade Bifidobacterium strains have emerged as promising candidates due to their safety, broad-spectrum activity, and physicochemical stability. This…

Chemistry. 2026 May 9:e71115. doi: 10.1002/chem.71115. Online ahead of print. ABSTRACT The siderophore synthetase DesD generates hydroxamic acid chelators with applications in metal-based radiopharmaceuticals and sequestering toxic or commodity metals. DesD has been used in chemoenzymatic syntheses with native substrates, with less focus on non-native substrates. This study investigated masking the modest activity of the…

Angew Chem Int Ed Engl. 2026 May 7:e1429706. doi: 10.1002/anie.1429706. Online ahead of print. ABSTRACT We report the first enzymatic synthesis of precisely defined metal-oligonucleotide conjugates through template-directed polymerase-mediated primer extension with two different (radio)metal-chelator-modified deoxyribonucleoside triphosphates. We successfully incorporated five different metals (Ga, In, Tb, Lu, and Y) along designed oligonucleotide templates, including the…

J Pharm Sci. 2026 Apr 29:104303. doi: 10.1016/j.xphs.2026.104303. Online ahead of print. ABSTRACT Recent advances in bispecific agents targeting both CD19 and CD20 highlight their potential as an effective strategy for improving clinical outcomes in B-cell malignancies. Herein, we developed a CD19/CD20 bispecific nanobody, 19Nb1-20Nb2, by fusing the anti-CD19 nanobody 19Nb1 to the N-terminus of…

J Am Chem Soc. 2026 Apr 29. doi: 10.1021/jacs.6c06067. Online ahead of print. ABSTRACT Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, preventing further research regarding their biological function. In biosynthesis, oxidases from plants generate the diverse oxidation…

Org Biomol Chem. 2026 Apr 23. doi: 10.1039/d6ob00328a. Online ahead of print. ABSTRACT The magic spot nucleotides (MSNs), (p)ppGpp and (p)ppApp, play central roles in bacterial stress signaling, yet their selective detection and chemical accessibility remain limited. This work presents a scalable chemo-enzymatic synthesis of natural and functionalized pentaphosphorylated MSNs based on a cyclic pyrophosphoryl…