MAbs. 2026 Dec;18(1):2652642. doi: 10.1080/19420862.2026.2652642. Epub 2026 Apr 2. ABSTRACT Monoclonal antibodies (mAbs) can mediate their therapeutic activity through antigen binding and by engaging Fc receptors (FcRs) or the complement system. FcRs are expressed on immune cells and can initiate effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis. The conserved Fc…

ACS Synth Biol. 2026 Apr 1. doi: 10.1021/acssynbio.5c00735. Online ahead of print. ABSTRACT Ergothioneine (EGT) is a unique natural chiral compound endowed with potent antioxidative, anti-inflammatory, and cytoprotective properties. Currently, EGT is primarily produced via bioextraction from mushrooms and chemical synthesis; however, the low efficiency and high costs associated with these methods hinder their ability…

Methods Enzymol. 2026;728:1-21. doi: 10.1016/bs.mie.2026.01.013. Epub 2026 Jan 20. ABSTRACT Phospholipid biogenesis couples fatty acid synthesis to glycerol acylation and headgroup installation, producing amphiphilic lipids that self-assemble into membranes. Reconstituting this process in the absence of pre-existing bilayers remains a central challenge for bottom-up synthetic biology and origins-of-life research. Here we describe a chemoenzymatic strategy…

JACS Au. 2026 Mar 10;6(3):2019-2029. doi: 10.1021/jacsau.6c00084. eCollection 2026 Mar 23. ABSTRACT The inherently low immunogenicity of tumor-associated carbohydrate antigens poses a significant obstacle to effective cancer immunotherapy. To address this challenge, we here report a biomimetic self-adjuvanting glycoprotein vaccine platform to elicit robust antitumor immunity against disialoganglioside GD2-positive cancers. This platform is constructed through…

Chemistry. 2026 Mar 26:e70931. doi: 10.1002/chem.70931. Online ahead of print. ABSTRACT Herein, we describe a modular, stereodivergent chemoenzymatic strategy for the enantioselective total synthesis of the natural products (+)- and (-)-glabridin. A lipase-catalyzed dynamic kinetic resolution establishes the key benzylic stereocenter, while a carefully engineered protecting-group manifold preserves stereochemical integrity during fragment coupling and cyclization.…

ACS Catal. 2026 Feb 27;16(6):5582-5591. doi: 10.1021/acscatal.5c08132. eCollection 2026 Mar 20. ABSTRACT Norisoprenoid compounds such as the damascones, damascenones, and megastigmatrienones are widely used in the flavor and fragrance industry. Their low natural abundance and the limitations of traditional synthetic routes, such as high energy demands, use of toxic reagents, and challenges in isomeric selectivity,…

Curr Opin Chem Biol. 2026 Mar 23;92:102668. doi: 10.1016/j.cbpa.2026.102668. Online ahead of print. ABSTRACT The complex chiral architectures of bioactive natural products pose significant challenges for traditional synthesis. The burgeoning field of chemoenzymatic synthesis, which strategically integrates the precision of biocatalysis with the power of synthetic chemistry, has provided conceptual innovations, including modular cascades, de…

Bioorg Chem. 2026 Mar 18;175:109770. doi: 10.1016/j.bioorg.2026.109770. Online ahead of print. ABSTRACT Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the main enzymes responsible for the development and progression of Alzheimer’s disease (AD). AChE and BChE hydrolyze acetylcholine (ACh), disrupting its management in neurotransmitters. In order to prevent and alleviate the symptoms of AD, the use of…

Biochim Biophys Acta Gen Subj. 2026 Mar 17;1870(6):130927. doi: 10.1016/j.bbagen.2026.130927. Online ahead of print. ABSTRACT Glycans that terminate in monosaccharides belonging to the sialic acid family of sugars regulate myriad biological processes and are increasingly being recognized as important immunoregulatory targets. These sialoglycans are biosynthesized by sialyltransferase enzymes which catalyze the transfer of CMP-sialic acid…

Proc Natl Acad Sci U S A. 2026 Mar 24;123(12):e2530653123. doi: 10.1073/pnas.2530653123. Epub 2026 Mar 18. ABSTRACT Antibody effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and various complement-dependent activities are critically influenced by the structure and composition of Fc N-glycans. Terminal galactosylation is generally associated with enhanced FcγRIIIA binding and C1q recruitment, thereby improving…