BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Carbohydr Res. 2026 Jul 31;568:110057. doi: 10.1016/j.carres.2026.110057. Online ahead of print. ABSTRACT Sulfosugars are organosulfur metabolites that contribute to global sulfur cycling, yet the metabolism of the rarer sulfofucose (SFuc) remains poorly defined, in part due to limited access to authentic standards. We report a scalable five-step synthesis of SFuc from d-galactose, including a uniformly…
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STAR Protoc. 2026 Aug 4;7(3):104762. doi: 10.1016/j.xpro.2026.104762. Online ahead of print. ABSTRACT Backbone thiazole moieties (Thz) are prevalent structural features in peptidic natural products and contribute to favorable physicochemical properties. Here, we describe a protocol for in vitro chemoenzymatic synthesis of artificial Thz-containing macrocyclic peptides compatible with mRNA display workflows. We provide steps for preparing…
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Front Bioeng Biotechnol. 2026 Jul 20;14:1867973. doi: 10.3389/fbioe.2026.1867973. eCollection 2026. ABSTRACT Sulfonamides remain important to medicinal and fine-chemical production but conventional aniline precursor routes like Pd-catalysed hydrogenation and Béchamp reductions carry sustainability, safety, and chemoselectivity challenges, especially for N-S bond integrity. This review assesses biocatalytic nitroreduction as a selective alternative for nitro-sulfonamides, focusing on p-aminobenzenesulfonamide…
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Chemistry. 2026 Aug 3:e71504. doi: 10.1002/chem.71504. Online ahead of print. ABSTRACT Stimuli-responsive regulation of enzyme activity is an important strategy to optimize biocatalytic performance across diverse operating environments. Herein, we report a thermoresponsive hybrid nanomaterial (HM) composed of Candida antarctica fraction B (CALB) immobilized on gold nanoparticles (AuNPs) and coated with poly(N-isopropylacrylamide) (PNIPAm). This system…
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Nat Prod Rep. 2026 Aug 3. doi: 10.1039/d6np00062b. Online ahead of print. ABSTRACT Covering: 1995 up to the end of 2025Homocyclic aromatic compounds (HAC) represent the second most abundant class of natural and anthropogenic products. Their biodegradation is central to the global carbon cycle and the bioremediation of aromatic pollutants. A key step in this…
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Zhongguo Zhong Yao Za Zhi. 2026 Jul;51(14):3989-3996. doi: 10.19540/j.cnki.cjcmm.20260330.402. ABSTRACT Ursodeoxycholic acid(UDCA) is a first-line drug for the clinical treatment of hepatobiliary diseases. The bioconversion of chenodeoxycholic acid(CDCA) based on whole-cell catalysis provides an important alternative approach for its green production. However, during fermentation, cellular aging and CDCA-induced stress lead to decreased stability of the…
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Methods Mol Biol. 2026;3018:289-311. doi: 10.1007/978-1-0716-5166-7_19. ABSTRACT Glycosylation is an important post-translational modification that can alter the biological activities of antibodies. In monoclonal antibody biotherapeutic products, glycosylation of the Fc-domain, which is often sensitive to manufacturing conditions, can alter product potency by affecting its interactions with host immune cells. Improving control of antibody glycosylation to…
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Int J Biol Macromol. 2026 Aug 1:153874. doi: 10.1016/j.ijbiomac.2026.153874. Online ahead of print. ABSTRACT 3D-printed gelatin scaffolds are widely explored for bone regeneration due to their excellent biocompatibility and biodegradability, yet their clinical translation is severely hindered by several inherent defects, including weak mechanical stability, fast in vivo biodegradation, limited osteogenic capability, and the absence…
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ACS Omega. 2026 Jul 15;11(29):43107-43115. doi: 10.1021/acsomega.5c12178. eCollection 2026 Jul 28. ABSTRACT The metabolic cooperation between plants and their endophytic fungi represents a promising frontier in the biosynthesis of natural products. This study elucidates the contribution of the endophytic fungus Fusarium oxysporum Po18 to the production of aromatic polyketides that drive specialized metabolism in Peperomia…
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Metab Eng Commun. 2026 Jul 21;23:e00286. doi: 10.1016/j.mec.2026.e00286. eCollection 2026 Dec. ABSTRACT N,N-dimethyltryptamine (DMT) is a bioactive indole alkaloid that could greatly benefit from scalable, fermentation-based production for research and pharmaceutical applications. In this study, we reconstructed a two-step bacterial pathway converting L-tryptophan to DMT via tryptamine. This involved combining a pyridoxal 5′-phosphate (PLP)-dependent tryptophan…