BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Proc Natl Acad Sci U S A. 2026 Feb 17;123(7):e2529018123. doi: 10.1073/pnas.2529018123. Epub 2026 Feb 9. ABSTRACT Cross-couplings are essential reactions in modern chemical synthesis, enabling the rapid construction of complex molecules from simple precursors. Transition metal catalysts are prized for these transformations because their reactivity and selectivity can be tuned via judicious selection of…
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Bioresour Bioprocess. 2026 Jan 27;13(1):16. doi: 10.1186/s40643-025-00984-4. ABSTRACT As one of the most abundant natural polysaccharides on Earth, chitin is limited in its high-value utilization by its natural insolubility and high crystalline structure. Enzymatic degradation-especially via chitinases-serves as a highly promising approach for the green bioconversion of insoluble chitin. This review systematically analyzes the structural…
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Sci Rep. 2026 Jan 27;16(1):6411. doi: 10.1038/s41598-026-37715-4. ABSTRACT Polyvinyl alcohol (PVA) is a widely used industrial polymer, and its persistence in the environment poses significant challenges, making the study of its biodegradation both a major production concern and an important scientific issue. This study aimed to elucidate the enzymatic mechanisms of PVA biodegradation by identifying…
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Data Brief. 2026 Jan 8;64:112453. doi: 10.1016/j.dib.2026.112453. eCollection 2026 Feb. ABSTRACT This dataset provides a comprehensive genomic and pathogenicity profiling of Staphylococcus aureus strain IHS3A, a methicillin-resistant (MRSA) clinical isolate obtained from a healthcare worker in a teaching hospital in Jordan, Middle East. Whole genome sequencing was performed using the Illumina NextSeq 2000 platform, followed…
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JACS Au. 2026 Mar 10;6(3):2019-2029. doi: 10.1021/jacsau.6c00084. eCollection 2026 Mar 23. ABSTRACT The inherently low immunogenicity of tumor-associated carbohydrate antigens poses a significant obstacle to effective cancer immunotherapy. To address this challenge, we here report a biomimetic self-adjuvanting glycoprotein vaccine platform to elicit robust antitumor immunity against disialoganglioside GD2-positive cancers. This platform is constructed through…
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Methods Enzymol. 2026;728:1-21. doi: 10.1016/bs.mie.2026.01.013. Epub 2026 Jan 20. ABSTRACT Phospholipid biogenesis couples fatty acid synthesis to glycerol acylation and headgroup installation, producing amphiphilic lipids that self-assemble into membranes. Reconstituting this process in the absence of pre-existing bilayers remains a central challenge for bottom-up synthetic biology and origins-of-life research. Here we describe a chemoenzymatic strategy…
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Curr Opin Chem Biol. 2026 Mar 23;92:102668. doi: 10.1016/j.cbpa.2026.102668. Online ahead of print. ABSTRACT The complex chiral architectures of bioactive natural products pose significant challenges for traditional synthesis. The burgeoning field of chemoenzymatic synthesis, which strategically integrates the precision of biocatalysis with the power of synthetic chemistry, has provided conceptual innovations, including modular cascades, de…
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Chemoenzymatic Synthesis of Norisoprenoid Aroma Compounds via C-H Activation by Engineered P450(BM3)
ACS Catal. 2026 Feb 27;16(6):5582-5591. doi: 10.1021/acscatal.5c08132. eCollection 2026 Mar 20. ABSTRACT Norisoprenoid compounds such as the damascones, damascenones, and megastigmatrienones are widely used in the flavor and fragrance industry. Their low natural abundance and the limitations of traditional synthetic routes, such as high energy demands, use of toxic reagents, and challenges in isomeric selectivity,…
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Chemistry. 2026 Mar 26:e70931. doi: 10.1002/chem.70931. Online ahead of print. ABSTRACT Herein, we describe a modular, stereodivergent chemoenzymatic strategy for the enantioselective total synthesis of the natural products (+)- and (-)-glabridin. A lipase-catalyzed dynamic kinetic resolution establishes the key benzylic stereocenter, while a carefully engineered protecting-group manifold preserves stereochemical integrity during fragment coupling and cyclization.…
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Proc Natl Acad Sci U S A. 2026 Mar 24;123(12):e2530653123. doi: 10.1073/pnas.2530653123. Epub 2026 Mar 18. ABSTRACT Antibody effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and various complement-dependent activities are critically influenced by the structure and composition of Fc N-glycans. Terminal galactosylation is generally associated with enhanced FcγRIIIA binding and C1q recruitment, thereby improving…