BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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Biochim Biophys Acta Gen Subj. 2026 Mar 17;1870(6):130927. doi: 10.1016/j.bbagen.2026.130927. Online ahead of print. ABSTRACT Glycans that terminate in monosaccharides belonging to the sialic acid family of sugars regulate myriad biological processes and are increasingly being recognized as important immunoregulatory targets. These sialoglycans are biosynthesized by sialyltransferase enzymes which catalyze the transfer of CMP-sialic acid…
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Bioorg Chem. 2026 Mar 18;175:109770. doi: 10.1016/j.bioorg.2026.109770. Online ahead of print. ABSTRACT Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the main enzymes responsible for the development and progression of Alzheimer’s disease (AD). AChE and BChE hydrolyze acetylcholine (ACh), disrupting its management in neurotransmitters. In order to prevent and alleviate the symptoms of AD, the use of…
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Chemistry. 2026 Mar 14:e70857. doi: 10.1002/chem.70857. Online ahead of print. ABSTRACT Sulfoquinovose (SQ) is a major biogenic sulfonated sugar whose degradation fuels microbial sulfur and carbon cycling. In the sulfoglycolytic Entner-Doudoroff (sulfo-ED) pathway, 2-keto-3,6-dideoxy-6-sulfogluconate (KDSG) is cleaved by KDSG aldolase to yield pyruvate and sulfolactaldehyde, yet the structure and mechanism of this enzyme have remained…
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ChemSusChem. 2026 Mar 27;19(6):e202501501. doi: 10.1002/cssc.202501501. ABSTRACT Amide bond formation is a key transformation in organic synthesis, especially for the preparation of active pharmaceutical ingredients (APIs). In this work, we report the development of a bio-organocatalytic cascade, combining stereoselective transamination catalyzed by ω-transaminases (ω-TAs) in neat organic solvent and choline chloride (ChCl)-mediated direct amidation. This…
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ACS Synth Biol. 2026 Mar 30. doi: 10.1021/acssynbio.5c00740. Online ahead of print. ABSTRACT Triterpenoid saponins are widely distributed natural products with diverse pharmacological activities. They are synthesized through the attachment of sugar moieties to the triterpenoid skeleton, a process catalyzed by UDP-glycosyltransferases (UGTs). However, the UGTs responsible for the glycosylation of many triterpenoids remain unidentified,…
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J Agric Food Chem. 2026 Mar 29. doi: 10.1021/acs.jafc.5c17253. Online ahead of print. ABSTRACT Halogenated organic compounds represent a significant environmental hazard due to their persistence and resistance to degradation. Dehalogenases, enzymes that efficiently remove halogens, offer versatile solutions for environmental remediation, green synthesis, and biocatalysis. For instance, LinB dehalogenates β-HCH to pentachlorocyclohexanol, and HHDH…
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Front Cell Infect Microbiol. 2026 Mar 13;16:1768480. doi: 10.3389/fcimb.2026.1768480. eCollection 2026. ABSTRACT The capacity for biofilm formation is a fundamental defense mechanism among antimicrobial-resistant pathogenic strains. In addition, its persistence may result in chronic colonization of host systems, and uncontrolled growth may lead to dangerous flow blockages, particularly in catheter-associated urinary tract infections. This warrants…
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Proc Natl Acad Sci U S A. 2026 Apr 7;123(14):e2532672123. doi: 10.1073/pnas.2532672123. Epub 2026 Mar 30. ABSTRACT Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are structurally diverse natural products that possess a range of bioactivities, often acting as antibiotics, antifungals, or metallophores. In RiPP biosynthesis, different modifying enzymes install an array of chemical motifs onto…
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Theriogenology. 2026 Mar 27;259:117914. doi: 10.1016/j.theriogenology.2026.117914. Online ahead of print. ABSTRACT Hydroxychalcones are phenolic chalcone derivatives with antioxidant activity and affinity for lipid-rich membranes, enabling modulation of oxidative processes such as lipid peroxidation. Because cryopreservation exposes canine spermatozoa to severe oxidative stress and membrane damage, these compounds represent potential candidates for redox modulation during cryogenic…
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